Electric Literature of 7343-33-1, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole, molecular formula is C2H2BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
2 – (6 – chloro – 3 – ethanesulfonyl – pyridin – 2 – yl) – 3 – methyl – 6 – trifluoromethyl – 3 H – imidazo [4,5 – b] pyridine300 mg,Potassium carbonate133 mg, and N, N-dimethylformamide 3 mL, 3-boule132 mg of lomo-1 H-1,2,4-triazole was added. And the mixture was stirred for 2.5 hours under ice coolingAfter that, a saturated multilayer aqueous solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. Water and saturated organic layerWashed with Japanese salt water, and dried with anhydrous sodium sulfate. The obtained organic layer was dried under reduced pressure.The obtained residue was subjected to silica gel chromatography, and the following compound 3 described below was separated by 370 mg.
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Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NISHIGUCHI, NAONOBU; SUNAMURA, EIRIKI; (25 pag.)JP2017/52702; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics