Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 16681-65-5, name is 1-Methyl-1H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 16681-65-5
Example 93: (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(3,5-dimethylisoxazol-4-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol To a flask containing 1 -methyl- lH-1, 2, 3-triazole (200 mg, 2.41 mmol) was added THF (17 mL) and the solution was cooled to -43 C using a CH3CN-CQ2bath. -BuLi, (2,5 M in hexanes, 0.88 mL, 2.19 mmol) was then added dropwise to provide a white suspension. The suspension was stirred at -40 C for 20 minutes, then a homogeneous solution of (4-chloro-2-methoxy-3-(4- (trifluoromethyl)benzyl)quinolii^ (500 mg, 1.05 mmol, Intermediate 63: step b) in 2 ml, TFIF was introduced. A dark brownish solution immediately resulted. The reaction mixture was allowed to warm gradually to 0 C over 25 minutes, then was quenched with aqueous H4CI solution. The aqueous portion was extracted with EtOAc (3 x 35 mL) and the combined organics were washed with brine, dried over MgS04, filtered and concentrated to dryness. The residue was purified by FCC (20% EtOAc-hexanes increasing to 50% EtOAc) to provide the title compound as a white solid. H NMR (500 MHz,CDC ) delta 8.08 (d, J —— 2.1 Hz, 1 H), 7.85 (d, J —— 8.7 Hz, IH), 7.61 – 7.46 (m, 3H), 7.39 (d, J —— 8.1Hz, 2H), 6.94 (s, IH), 4.81 (s, IH), 4.32 (s, 2H), 4.09 (s, 3H), 3.98 (s, 3H), 1.95 (s, 3H), 1.82 (s, 3H); MS (ESI): mass calc. for Chemical Formula: C27H23CIF3N5Q3; Exact Mass: 557.1, m z found, 557.9 (M+H).
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 16681-65-5
Reference:
Patent; JANSSEN PHARMACEUTICA NV; LEONARD, Kristi A.; BARBAY, Kent; EDWARDS, James P.; KREUTTER, Kevin D.; KUMMER, David A.; MAHAROOF, Umar; NISHIMURA, Rachel; URBANSKI, Maud; VENKATESAN, Hariharan; WANG, Aihua; WOLIN, Ronald L.; WOODS, Craig R.; FOURIE, Anne; XUE, Xiaohua; CUMMINGS, Maxwell D.; JONES, William Moore; GOLDBERG, Steven; WO2015/57205; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics