A dinuclear Ni(II) complex [Ni2 (Htda)2 (H2O)6]·4H2O: interaction with DNA and apoptosis studies was written by Wu, Guang-lei;Zhan, Lin;Xu, Jin;Gao, En-jun. And the article was included in Shenyang Huagong Daxue Xuebao in 2012.Quality Control of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:
The interaction of the Ni (II) complex [Ni2 (Htda)2 (H2O)6]·4H2O (Htda=1,2,3-triazole-4,5-dicarboxylic acid acisamples) with DNA has been explored by electronic absorption spectroscopy, emission spectroscopy and gel electrophoretic assay. The results show that the modes of the interaction between complex and DNA are mainly electrostatic interaction and intercalation. Further more, the apoptotic tests indicate that the complexes have an apoptotic effect on HeLa cells. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Quality Control of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).
1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeQuality Control of 1H-1,2,3-Triazole-4,5-dicarboxylic acid
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics