Synthetic Route of 16681-70-2, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
[0752] Compound 1 (4 mg, 50 f.tmol) was dissolved inMeCN (1 mL) and dry 4N HCI in dioxane (0.5 mL). Themixture was stirred for 1 0 minutes and then concentratedunder reduced pressure to yield Compound 2, which wascarried to the next step without purification
I am very proud of our efforts over the past few months and hope to 1H-[1,2,3]Triazole-4-carboxylic acid help many people in the next few years.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics