Application of 7170-01-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows.
Example 4; Preparation of Compound C’ from Compound B’ (Example 2); Compound B’ (60.00 g, 0.274 mol) (prepared as in Example 2) was added in portions to a melt of 3-methyl-1,2,4-triazole (113.8 g, 1.369 mol) under argon at 110-120 C. The mixture was heated to about 143 C. and the resulting solution was stirred at 142-44 C. for 17 h. After cooling to 120 C., 1-methyl-2-pyrrolidinone (NMP) (60 mL) was added quickly. The solution was further cooled to about 95 C. and water (300 mL) was added slowly (about 30 min.) keeping the temperature at 85 and 95 C. resulting in crystallization of the product. The slurry was cooled slowly to 0-5 C. and held for about 1 h. The cold slurry was filtered and the cake washed with cold H2O (2¡Á75 mL) then dried in vacuo at 55 C. for 16 h affording 34.5 g Compound C’ as a crystalline, tan solid (54.9%), HPLC AP 98.2. If necessary, the product could be further purified by recrystallization from ethyl acetate. 1H NMR (400 MHz, CDCl3) delta 2.55 (s, 3H), 4.05 (s, 3H), 6.73 (dd, 1H, J=2.9, 2.6), 7.42 (dd, 1H, J=2.9, 2.8), 7.57 (s, 1H), 9.16 (s, 1H), 10.29 (bs, 1H). Anal. Calcd for C11H11N5O: C, 57.63; H, 4.84; N, 30.55. Found: C, 57.37; H, 4.74; N, 30.79.
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bristol-Myers Squibb Company; US2006/293304; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics