Synthetic Route of 288-36-8, The chemical industry reduces the impact on the environment during synthesis 288-36-8, name is 1H-1,2,3-Triazole, I believe this compound will play a more active role in future production and life.
To a mixture of the product from step 2 (7.9 g, 38 mmoi), Cs2CO3 (24.8 g,76 mmol) and Cui (2.88 g, 7,6 inmol) in DMF (200 mL) were added 21-{41,2,3ltriazole (5.24 g,76 rnrnoi) and N,Ndimethyi-cyciohexanei,2-diamine (0.9 g, 6.5 rnmoi) and the mixture was stirred at 110C overnight. The cooled mixture was adjusled to pHi2 with 1M sodium hydroxide and extracled with EtOAc (50 mL x 3). The aqueous layer was adjusted to pH 4 with I M FIC and extractedwith EtOAc (50 mLx4). The extracts was dried over Na2SO4, filtered, the filtrate concentrated in vacuo and the residue purified by chromatography on silica (Petroleum ether : EtOAc =10:1) to provide the title compound. LRMS m/z (M-f-1-1) 196.0 found, 196.0 required.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics