Tag: M.W=300-400

Reference of 1533519-85-5, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

The compound a1 (50 g, 147.3 mmol, 1.0 eq.) Was dissolved in 500 mL of acetone, stirred at 20 to 30 C, methyl bromoacetate (1473 mmol, 10 eq.) Was added and reacted for 12 hours. The reaction solution was concentrated to dryness , And the concentrate was recrystallized from ethyl acetate to obtain 56.4 g of the catalyst b1 in a yield of 77.8%.

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Reference:
Patent; Beijing Xin To Lead Pharmaceutical Co., Ltd.; Wang Hui; Zhen Zhibin; Zhang Xiang; (10 pag.)CN106916115; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 31250-99-4, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 31250-99-4, name is 1-Trityl-1H-1,2,4-triazole, molecular formula is C21H17N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

EXAMPLE 6 This Example illustrates the preparation of 1-trityl-3-bromo-1,2,4-triazole. A stirred solution of 1-trityl-1,2,4-triazole (15.55 g, prepared as described in Example 1) and N,N,N’,N’-tetramethylethylenediamine (5.8 g) in dry tetrahydrofuran (500 ml) was cooled to -70 C. under nitrogen and treated dropwise with n-butyllithium (37.5 ml, 1.6M in hexane). The deep-red solution was stirred at -70 C. for twenty minutes, then treated dropwise with a solution of bromine (10.4 g) in dry tetrahydrofuran (10 ml). The now brownish-yellow solution was allowed to warm to -20 C., quenched with 0.1M sodium thiosulphate solution (150 ml), and extracted with dichloromethane (500 ml). The organic layer was washed with water (4*100 ml), dried and evaporated. The residue was chromatographed on silica, using dichloromethane-ether (25:2) as eluant, to give 1-trityl-5-bromo-1,2,4-triazole (7.86 g, m.p. 239-241 C.). NMR (CDCl3):delta7.1-7.3(15H,m), 7.95(1H,s).

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Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol

Complex trans-[PdCl2L2] (I) was prepared at 20by methods A and B at different predetermined Pd(II):L molar ratios. Method A: The batch ratio was Pd(II) : L = 1 : 2.To a magnetically stirred aqueous solution (3 mL) containing K2[PdCl4] (0.30 g, 0.92 mmol), the reagent L (0.57 g, 1.84 mmol) dissolved in acetone (6.5 mL)was added. The brown color of the solution quickly changed to orange. The bulky yellow precipitate was formed in 5 h; in 16 h after the evaporation of acetone,the precipitate was filtered out, washed with water and then hexane, and dried in air. The yield was 97%. Method B: The predetermined ratio was Pd(II) : L =1 : 1. To an aqueous solution (3 mL) containing K2[PdCl4] (0.30 g, 0.92 mmol), the reagent (0.28 g,0.92 mmol) dissolved in acetone (6.5 mL) was added under stirring. A yellow precipitate was formed in few minutes. After stirring for 24 h the precipitate was filtered out, washed with water and hexane, and dried. The yield was 81% based on the reagent.

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Reference:
Article; Khisamutdinov; Shitikova; Anpilogova; Golubyatnikova; Mulagaleev; Murinov; Russian Journal of Inorganic Chemistry; vol. 60; 5; (2015); p. 638 – 646; Zh. Neorg. Khim.; vol. 60; 5; (2015); p. 710 – 718,9;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 1533519-85-5, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

In a 100 ml three-necked flask equipped with a stirrer, a thermometer, 25 ml of DMF was added, the intermediate (IV)3.39 g, stirred at room temperature, 0.42 g of sodium hydroxide was added and 1.87 g of NBS was added in portions at 25 C,Add to maintain the stirring for 3 hours; add 50ml of water, then ethyl acetate 50ml x3 extraction, combined organicThe phases were concentrated and the ethyl acetate was removed by adding 25 ml of ethyl acetate / 50 ml of n-hexane to recrystallize,To give the product 3.55 g, i.e. intermediate (V), in a yield of 84.93%.

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Reference:
Patent; Chengdu Baoyu Pharmaceutical Co., Ltd.; Lei, Lang; Li, Shanwei; Xiong, Bo; (10 pag.)CN105906576; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 107534-96-3, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, molecular formula is C16H22ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

First, tebuconazole (184 mg, 0.6 mmol) was dissolved in anhydrous dichloromethaneIn (CH2Cl2, 15 mL), add triethylamine(C6H15N, 730 mg, 7.2 mmol), after stirring in an ice bath for 5 minutes,Addition of monoethylmonosuccinate (C6H9ClO3, 988 mg, 6 mmol)Stir overnight at room temperature, followed by washing with water and saturated saline(15 mL×3, respectively), after drying the dichloromethane with anhydrous sodium sulfate,It was filtered, evaporated to dryness under reduced pressure to give the intermediate product (about 400 mg).Used directly for the next hydrolysis. The product structure was characterized by LC/MS.

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Reference:
Patent; Henan University of Science and Technology; Chen Xiujin; Li Zhaozhou; Wang Yao; Gao Hongli; Li Zhili; Cao Li; Li Daomin; Xu Chuanlai; (16 pag.)CN106674138; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1533519-85-5, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

For the 250 ml reaction bottle B join the previous step product (4 g, 0.0118 muM), tetrahydrofuran (30 ml), tetramethyl piperidine (TEMPO, 0.2 g, 0.1 eq), oil bath 30 – 32 C heating and stirring, to dissolve to clarify. Batch by adding N – bromo succinimide (NBS, 3.2 g, 0 . 018 muM, 1.5 eq), temperature control not more than 35 C. Canada finishes, thermal insulation 30 – 32 C reaction 3 h. Detection of the raw material after the reaction is complete, stop heating, ice bath cooling. To be in reaches warm 0 – 5 C, batch by adding sodium sulfite aqueous solution quenching reaction, ethyl acetate extraction, anhydrous sodium sulfate drying, filtering, and concentration, drying, and the produced intermediate C crude product can be directly used for the next step reaction. Analysis of the sample through the column chromatography (200 – 300 mesh silica gel, eluent is dichloromethane: methanol=15:1) purification, to obtain white solid C.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, hurry up and to see.

Reference:
Patent; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shanghai Jingxin Bio-pharmaceutical Co., Ltd.; Dai Xiangqian; Huang Yue; (17 pag.)CN107098866; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol

The complex was synthesized by two methods. To an aqueous solution (3 mL) containing Na2[PtCl6]*6H2O (0.50 g, 0.89 mmol), reagent L (0.27 g, 0.89 mmol) (method A) or (0.55 g, 1.78 mmol) (method B) in acetone (7 mL) was added under stirring. A yellow precipitate was quickly formed. After 72 h, the precipitate was filtered out, washed with water and hexane, and dried in air. The yield based on reagent L was 67% (method A) and 90% (method B).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, in my other articles.

Reference:
Article; Khisamutdinov; Anpilogova; Shitikova; Murinov, Yu. I.; Russian Journal of Inorganic Chemistry; vol. 61; 12; (2016); p. 1530 – 1537; Zh. Neorg. Khim.; vol. 61; 12; (2016); p. 1591 – 1598,8;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 178928-70-6, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 178928-70-6, name is 2-(2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazole-3(2H)-thione, molecular formula is C14H15Cl2N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

1.1 Weigh 50 mg of the compound of formula I into a 10 mL sample vial, dissolve in 1.0 mL of diethylamine at room temperature and shake slightly until it is clear. When 5.0 mL of n-heptane was added dropwise, the solution appeared white turbid. After standing for 24 hours, light brown lump single crystals precipitated at the bottom of the bottle, and the color was darker. Filter out part of the single crystal, put it in a vacuum oven and dry for 6h, then the diethylamine solvate of the present invention can be obtained.

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Reference:
Patent; East China University of Science and Technology; Li Zhong; Ren Guobin; Xu Xiaoyong; Hong Minghuang; Gong Chengyu; Hu Jian; (17 pag.)CN110272393; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 107534-96-3, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, molecular formula is C16H22ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Example 8 Synthesis of 2-{2-[2-(4-chloro-phenyl)-ethyl]-2-hydroxy-3,3-dimethyl-butyl}- 2,4-dihydro-[1 ,2,4]triazole-3-thioneTo an ice-cold solution of 1 -(4-chloro-phenyl)-4,4-dimethyl-3-[1 ,2,4]triazol-1 -ylmethyl- pentan-3-ol (236 mg, 0.77 mmol) in 2 mL of THF was added a solution iPrMgCI in THF (2.0 M, 1 .0 mL, 2.0 mmol). The solution was warmed to 40 C and kept at that temperature for 90 min. Then, it was cooled to 0 C and treated and a suspension of sulfur (75 g, 2.34 mmol) in 1 mL of THF was added portionwise and the mixture stirred for another 60 min at 0 C. The solution was then poured onto 4% HCI (20 mL). The a- queous phase was extracted with TBME (2×30 mL). The combined org. phases were successively washed with water and brine. The crude product was obtained after drying over Na2S04 and removal of all volatiles. Purification was accomplished through flash column chromatography on silica (cyclohexane/EtOAc mixtures) to obtain the product as a colorless liquid (151 mg, 0.44 mmol, 58% yield).1H N R (DMSO-de. 500 MHz): delta (ppm) = 8.40 (s, 1 H); 7.29 (d, J = 12.0 Hz, 2 H); 7.18 (d, J = 12.0 Hz, 2 H); 4.51 -4.58 (m, 2 H); 4.00-4.06 (m, 1 H); 2.61 (dt, J = 5.0 Hz, J = 17.0 Hz, 1 H); 2.20-2.30 (m, 1 H); 1 .94-2.04 (m, 1 H); 1 .70 (dt, J = 5.0 Hz, J = 19.0 Hz, 1 H); 0.94 (s, 9 H).

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, hurry up and to see.

Reference:
Patent; BASF SE; DOCHNAHL, Maximilian; KEIL, Michael; GEBHARDT, Joachim; VOGELBACHER, Uwe Josef; MENGES, Frederik; RACK, Michael; RENNER, Jens; WOLF, Bernd; WO2011/113820; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 107534-96-3

Photocatalytic experiments were performed in a photochemical reactor Suntest XLS+ solar simulator (Atlas, Germany) equippedwith a vapor xenon lamp (2.2 kW). The light source was jackedwith special glass filters restricting the transmission of wave-lengths below 290 nm. A Pyrex reactor with a total volume of250 mL was used to study the photocatalytic degradation of TEB.Suspensions of TEB solutions containing different amounts of theTiO2photocatalyst were stirred in the dark for 30 min to achieveadsorption-desorption equilibrium. After this period, the light wasturned on for the photocatalytic degradation experiments.As the reaction progressed, aliquots were withdrawn fromthe reactor at specific time intervals and filtered through HVLP(0.45 m) filters supplied by Millipore to remove TiO2 particlesbefore further analysis. Adsorption and photolytic experiments were also conducted. TEB solutions were prepared in ultrapurewater and wastewaters and the experiments were performed at room temperature

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol help many people in the next few years.

Reference:
Article; Stamatis; Antonopoulou; Konstantinou; Catalysis Today; vol. 252; (2015); p. 93 – 99;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics