Tag: M.W:100-200

Application of 16681-70-2, The chemical industry reduces the impact on the environment during synthesis 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

[0864] lH-1,2,3-triazole-4-carboxylic acid (9.8 mg, 87f.tmol) and HATU (36.4 mg, 96 f.tmol) were combined in DMF(3.0 mL) and stirred at room temperature for 15 minutes. Compound 2 (40.3 mg, 87 fllllOl) and DIPEA (46 f.LL, 261f.tmol) were added and the resulting solution was stirred atroom temperature for 15 minutes, after which time LCMSindicated desired product formation. The solvent wasremoved in vacuo and the crude residue was purified byreverse phase chromatography to yield Compound c (34.5mg) as a TFA salt. MS m/z [M+Ht calc’d forC28H33ClFN50 4 , 558.22. found 558.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4314-22-1, name is 2-(1H-1,2,3-Triazol-1-yl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4314-22-1

(ii) In a manner analogous to that described in Example 8 from (E)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-2′-(2-ethylbutyl)-4-methylvalerohydrazide and using 1,2,3-triazole-1-acetic acid in place of N-tert-butoxycarbonyl-beta-alanine there was obtained (E)-2(R)-[1(S)-(benzyloxycarbamoyl)-4-phenyl-3-butenyl]-2′-(2-ethylbutyl)-4-methyl-2′-[2-(1H-1,2,3-triazol-1-yl)acetyl]valerohydrazide in the form of a gum.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4314-22-1.

Reference:
Patent; Hoffmann-La Roche Inc.; US6239151; (2001); B1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 202931-88-2, name is 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde

To a flask containing 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline (1.45 g, 3.37 mmol, Intermediate 10: step d) was added THF (25 mL) and the solution was cooled to -75 C. n-BuLi (2.5 M in hexanes, 1.3 mL, 3.25 mmol) was added dropwise. After 2 minutes, 1-methyl-1H-1,2,3-triazole-5-carbaldehyde (580 mg, 5.22 mmol, Intermediate 18) in 3 mL THF was introduced. The reaction mixture was allowed to warm to -20 C. over 45 minutes at which time the reaction was quenched with aqueous NH4Cl solution. The aqueous portion was extracted with EtOAc (5*40 mL) and the combined organics were washed with brine, dried over MgSO4, filtered and concentrated. Chromatography on silica gel (5% CH3CN-DCM increasing to 30% CH3CN +2% MeOH) afforded the title compound as an off white amorphous solid. 1H NMR (600 MHz, CDCl3) delta 8.15 (d, J=1.9 Hz, 1H), 7.82 (d, J=8.6 Hz, 1H), 7.54 (dd, J=8.6, 2.0 Hz, 1H), 7.49 (d, J=8.2 Hz, 2H), 7.38 (d, J=8.1 Hz, 2H), 7.27 (s, 1H), 6.14 (d, J=4.6 Hz, 1H), 5.01 (s, 1H), 4.33 (s, 2H), 4.07 (s, 3H), 3.95 (s, 3H). MS (ESI): mass calcd. for C22H18ClF3N4O2, 462.1, m/z found 463.1 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; CUMMINGS, MAXWELL D.; US2015/105372; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1001401-62-2,Some common heterocyclic compound, 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, molecular formula is C9H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 4 (1.0 g, 4.42 mmol) and 2-(2H-1,2,3-triazol-2- yl)benzoic acid (0.84 g, 4.42 mol) in DCM (50 mL) was added HATU (1.70 g, 4.50 mmol), DIPEA (0.60 g, 4.5 mmol) succesively. The solution was stirred at RT for 9 h under N2, then poured into water (30 mL) and extracted with DCM (20 mL x 3). The combined organic layerswere washed with brine (30 mL), dried over Na2504, filtered and concentrated in vacuo. The residue was purified by column chromatography (petroleum ether: EtOAc = 7: 1 to 2 : 1) to give the title compound 5 (1.5 g,). LRMS m/z (M+H) 398.2 found, 398.2 required.

The synthetic route of 1001401-62-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (97 pag.)WO2016/100157; (2016); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 27996-86-7,Some common heterocyclic compound, 27996-86-7, name is 4-[1,2,4]Triazol-1-yl-benzaldehyde, molecular formula is C9H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-(1 H-1 ,2,4-triazol-1-yl)benzaldehyde (400 mg, 2.28 mmol) in dry MeOH (5 ml_), NaBH4 (93 mg, 2.74 mmol) was added at 0 C and the resulting mixture was stirred at RT for 2 h. After completion of the reaction, ice water was added and the mixture was extracted with EtOAc (2 x 20 ml_). The combined organic layer was washed with brine (2 ml_), dried over Na2S04 and concentrated under vacuum. The resulting crude product was purified by flash chromatography (Eluent: 34% EA in pet ether) to get the title product. Yield: 67% (271 mg, white solid). 1H NMR (400 MHz, DMSO-cfe): d 9.27 (s, 1 H), 9.25 (s, 1 H), 7.78 (d, J = 8.6 Hz, 2H), 7.13 (d, J = 8.6 Hz, 2H), 4.85 (s, 1 H), 3.96 (s, 2H). LCMS: (Method A) 176.1 (M+H), Rt.1.04 min, 99.79% (Max).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-[1,2,4]Triazol-1-yl-benzaldehyde, its application will become more common.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, COA of Formula: C3H3N3O2

cyanopyrrolidin-1 -yl)-2-oxoethyl)-1 H-1 ,2,3-triazole-5-carboxamide 1 H-1 ,2,3-triazole-4-carboxylic acid (0,092 g, 0,814 mmol) was dispersed in dry dioxane (3m L) in a round bottom flask with nitrogen. To this 1 -chloro-N,N,2-trimethylprop-1 -en-1 -amine (0,151 ml, 1 ,139 mmol) was added and the reaction was stirred for 30 minutes at room temperature. The starting material dissolves over time, Then (S)-1 -(2-aminoacetyl)pyrrolidine-2-carbonitrile hydrochloride (0,247 g, 1 ,302 mmol) with N-ethyl-N-isopropylpropan-2-amine (0,307 ml, 1 ,709 mmol) was added and the mixture was stirred for 2h, evaporated to dryness and redissolved in ethyl acetate. Followed by washing with 0.1 N citric acid and saturated sodium bicarbonate and – – brine. After drying over sodium sulfate, filtration and evaporation, the product was purified using column chromatography. Yield: 34mg, 40% 1 H NMR (400 MHz, DMSO) (9/1 mixture of trans/cis amide rotamers) delta 15.53 (s, 1 H), 8.58 – 8.44 (s, 1 H), 8.39 (s, 1 H), 5.28 – 5.22 (m, 0.1 H), 4.77 (dd, J = 3.76, 7.32 Hz, 1 H), 4.30 (dd, J = 5.61 , 16.77 Hz, 0.2H), 4.10 (d, J = 5.76 Hz, 2H), 3.68 (ddd, J = 4.04, 7.68, 9.39 Hz, 1 H), 3.50 (td, J = 6.84, 9.09 Hz, 1 H), 2.31 – 1 .88 (m, 4H). UPLC I (ESI) Rt 0.72 min, m/z 249.6 [M+H]+ (96%) ; LC-MS (l-B) Rt 4.0 min, m/z 249.0 [M+H]+ (96%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITEIT ANTWERPEN; FOX CHASE CANCER CENTER; JANSEN, Koen; DE MEESTER, Ingrid; HEIRBAUT, Leen; CHENG, Jonathan D; JOOSSENS, Jurgen; AUGUSTYNS, Koen; VAN DER VEKEN, Pieter; WO2013/107820; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 16681-70-2, The chemical industry reduces the impact on the environment during synthesis 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

lH-l,2,3-triazole-5-carboxylic acid (55.9 mg, 494 muiotaetaomicron) was combined with HATU (188 mg, 494 mupiiotaomicron) in DMF (0.5 mL) and stirred for 10 minutes; DIPEA (1.5 eq.) was added and the mixture was stirred for 1 minute. Compound 3 (200 mg, 494 muiotaetaomicron) was dissolved in DMF (1 mL) and DIPEA (259 mu^, 1.5 mmol) was added, followed by addition of the activated acid solution. The mixture was stirred for 30 minutes and the solvent was evaporated. The mixture was purified by normal phase chromatography (0-100% (0791) EtOAc/hexanes) to yield Compound 4 (100 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1H-[1,2,3]Triazole-4-carboxylic acid

[0674] Compound 10 (32 mg, 75 fllllOl, 1.0 eq.) was dissolvedinDMF(500 f.LL). lH-1,2,3-triazole-4-carboxylic acid(25 mg, 221 f.tmol, 3.0 eq.) was dissolved in DMF (500 f.LL),followed by the additionofDIPEA (51 f.LL, 297 f.tmol, 4.0 eq.)and HATU ( 42 mg, 111 f.tmol, 1.5 eq.). The solutions werestirred at room temperature for 20 minutes, then combinedand stirred at room temperature for an additional 20 minutesand when the reaction was complete (as determined byLC/MS analysis), the mixture was diluted with water (0.5mL), the pH adjusted to 4 with 10% citric acid, then washedwith EtOAc (2×20 mL). The aqueous phase was discardedand the combined organics were extracted with saturatedaqueous NaCl (10 mL). The aqueous phase was discarded andthe organic phase was dried over Na2S04 , filtered, and concentratedin vacuo, and purified by preparative HPLC to yieldthe title compound (11 mg; purity 99.6% ). LCMS (ESI): calc.C27H31N50 4=489; obs. M+H=490.2. Retention time: 4.23mm.

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 6818-99-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6818-99-1 as follows.

Step 1: Synthesis of Compounds of the Formula (IV) 6′-(3-Chloro-1,2,4-triazol-1-yl)-[1(2H), 3′-bipyridin]-2-one (IV-29) 250.0 mg (1.21 mmol) of 6′-chloro-[1(2H),3′-bipyridin]-2-one (IV-14) were stirred in 10 ml of N,N-dimethylformamide (DMF), 438.3 mg (4.23 mmol) of 3-chloro-1,2,4-triazole, 496.0 mg (3.58 mmol) of potassium carbonate, 29.9 mg (0.15 mmol) of copper(I) iodide and 65.4 mg (0.46 mmol) of N,N-dimethylcyclohexane-1,2-diamine were added and the mixture was stirred at 110 C. for 2 days. After cooling, the reaction mixture was extracted with saturated sodium chloride solution and ethyl acetate. For work-up, the organic phase was dried and concentrated under reduced pressure and the residue that remained was purified by column chromatography on silica gel (mobile phase: cyclohexane acetone gradient). This gave 38 mg (100.0% pure, 11.4% yield) of 6′-(3-chloro-1,2,4-triazol-1-yl)-[1(2H),3′-bipyridin]-2-one. Log P value (HCOOH)=1.23 LC-MS (ESI positive)=274.0 (M+) C12H8ClN5O (273.7 g/mol) 1H-NMR (400.0 MHz, DMSO-d6): delta=6.40; 6.55; 7.57; 7.79; 7.97; 8.22 (m, 6H, hetaryl-H); 8.67 (d, 1H, hetaryl-H); 9.51 (s, 1H, hetaryl-H) ppm.

According to the analysis of related databases, 6818-99-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer CropScience Aktiengesellschaft; JESCHKE, Peter; GUTBROD, Oliver; FISCHER, Reiner; HELLWEGE, Elke; LOESEL, Peter; MALSAM, Olga; EILMUS, Sascha; ILG, Kerstin; PORTZ, Daniela; GOERGENS, Ulrich; LISHCHYNSKYI, Anton; (69 pag.)US2018/201600; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 202931-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202931-88-2, name is 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

-78 in hexane ofn-butyllithium solution (1.6 M, 0.71 mL, 1.1 mmol) in tetrahydrofuran (11 mL) of 3 – (4 – (1H-pyrazol-1- yl) benzyl) -6 – bromo-4-chloro-2-methoxy-quinoline (490 mg, 1.1 mmol, intermediate 4: step d) of stirring the solution was added dropwise.After two minutes, tetrahydrofuran (1 mL) of 1-methyl -1H- 1, 2,3-triazole-5-carbaldehyde (140 mg, 1.1 mmol, Intermediate 18). After 5 minutes, the flask was placed in an ice water bath.After 1 hour, water was added (10 mL) and ethyl acetate (60 mL).The two phase mixture was stirred for 10 min.By the addition of half saturated aqueous sodium chloride solution (50 mL), the layers were separated.The organic layer was dried over sodium sulfate, filtered, the solution dried.Addition of silica gel (4 g) to the filtrate, the mixture was concentrated by rotary evaporation to give a free-flowing powder.Powder was loaded onto a silica gel column for flash column chromatography purification.Initially with 100% hexane and eluted by a grading to 100% ethyl acetate to give the title compound as an impure white foam.Suspending the foam in methanol (20 mL) and then the suspension was sonicated for 5 minutes.Collect the solid by filtration, and rinsed with methanol (5 mL).The combined solids dried to a white solid as the title compound was obtained.

The synthetic route of 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceuticals N.V; Leonardo, Christi.A.; Barvei, Kent; Edward, James P.; Gloita, Kevin D.; Kummer, David .A.; Maharoof, Umar; Nishimura, Rachael; Urbanski, Mode; Venkatesan, Hariharan; Wang, Ai Hua; Olin, Ronald L.; Woods, Craig; Fourier, Anne; Shu, Jih; Cumings, Maxwell D.; (86 pag.)KR2016/68948; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics