Tag: M.W:100-200

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, SDS of cas: 464-48-2464-48-2, Name is (-)-Camphor, SMILES is O=C1[C@@](C2(C)C)(C)CC[C@@]2([H])C1, belongs to Triazoles compound. In a article, author is Gu, Hao, introduce new discover of the category.

Tricyclic nitrogen-rich cation salts based on 1,2,3-triazole: Chemically stable and insensitive candidates for novel gas generant

A new tricyclic nitrogen-rich compound 4,5-bis(4,5-diamine-1,2,4-triazole-3-yl)-2H-1,2,3-triazole (2) was synthesized. Monovalent and divalent cations based on 1,2,3-triazole backbone were developed for energetic salts 3-13. It is worth mentioning that energetic salt 8 was obtained as a unique zwitterionic salt. These energetic compounds exhibit good thermal stability and positive heat of formation. Most of these newly synthesized compounds were insensitive to mechanical stimulation (IS >= 24 J, FS >= 252 N), while the sensitivity of compound 4 (IS = 7 J, FS = 120 N) is similar to that of RDX (IS = 7.4 J, FS = 120 N). Additionally, crystal analysis and theoretical calculations of crystals 2, 3, 4, 8 were carried to explore the relationship between strong hydrogen bonds and physicochemical properties. Furthermore, dinitramide salt 5 and zwitterionic salt 8 have relatively high theoretical detonation properties (5: D = 8770 m s(-1), 8: D = 8545 m s(-1)), which are close to RDX (D = 8795 m s(-1)). The compounds 2-5, 8 possess outstanding combustion performance (Pmax: 4.57-13.38 MPa) tested by constant-volume combustion experiments, which are superior to frequently-used gas generant guanidine nitrate. All the results demonstrate that dinitramide salt 5 and zwitterionic salt 8 with high volumes of detonation gas (5: 826.74 L kg(-1); 8: 799.77 L kg(-1)), moderate detonation performance and appropriate mechanical sensitivities (5: IS = 28 J, FS > 360 N; 8: IS > 40 J, FS > 360 N) may be useful as novel gas generant.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 464-48-2. SDS of cas: 464-48-2.

Synthetic Route of 5117-12-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5117-12-4, Name is 4-Acryloylmorpholine, SMILES is C=CC(=O)N1CCOCC1, belongs to Triazoles compound. In a article, author is Fernandez de Luco, Julia, introduce new discover of the category.

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

Triclosan and isoniazid are known antitubercular compounds that have proven to be also active against Leishmania parasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules triclosan and 5-octyl-2-phenoxyphenol (8PP) were designed in search of novel structures with leishmanicidal activity and prepared using different alkynes and azides. The 37 compounds were assayed against Leishmania donovani, the etiological agent of leishmaniasis, yielding some analogs with activity at micromolar concentrations and against M. tuberculosis H37Rv resulting in scarce active compounds with an MIC of 20 mu M. To study the mechanism of action of these catechols, we analyzed the inhibition activity of the library on the M. tuberculosis enoyl-ACP reductase (ENR) InhA, obtaining poor inhibition of the enzyme. The cytotoxicity against Vero cells was also tested, resulting in none of the compounds being cytotoxic at concentrations of up to 20 mu M. Derivative 5f could be considered a valuable starting point for future antileishmanial drug development. The validation of a putative leishmanial InhA orthologue as a therapeutic target needs to be further investigated.

Synthetic Route of 5117-12-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5117-12-4.

5117-12-4, Name is 4-Acryloylmorpholine, molecular formula is C7H11NO2, belongs to Triazoles compound, is a common compound. In a patnet, author is Sood, Rakhi, once mentioned the new application about 5117-12-4, Computed Properties of C7H11NO2.

Active electrospun nanofibers as an effective reinforcement for highly conducting and durable proton exchange membranes

Mechanical reinforcement of proton exchange membranes is a great challenge allowing the reduction of their thickness, with the advantages of lower resistance, improved water transport, decreased fuel crossover and high durability, which are crucial for fuel cells. We describe herein a new class of reinforced membranes based on nanofibers of polysulfone (PSU) functionalized with 4-heptyl-1,2,3-triazole (PSUT) likely interacting via hydrogen bonds or ionic cross-linking with a short-side-chain type perfluorosulfonic acid (Aquivion (R)) matrix. PSUT with two functionalization degrees was electrospun into webs which were impregnated with Aquivion (R) to afford composite membranes that presented higher dimensional stability in water, increased mechanical strength and Young modulus in comparison to reinforced membranes of non-functionalized PSU and pristine ionomer membrane, without any decrease in proton conductivity. Membrane-electrode assemblies incorporating an Aquivion (R) membrane reinforced with PSUT exhibited 5 times superior durability than those with a pristine Aquivion (R) membrane without any radical scavenger. These features may be ascribed to the specific interaction between basic fibers and acidic ionomer. The incorporation of webs of active fibers in ionomer membranes is an effective strategy of reinforcement leading to high performance and increased durability, which can be extended to other kinds of ion exchange membranes and devices.

If you¡¯re interested in learning more about 5117-12-4. The above is the message from the blog manager. Computed Properties of C7H11NO2.

1704-62-7, Name is 2-(2-(Dimethylamino)ethoxy)ethanol, molecular formula is C6H15NO2, Formula: C6H15NO2, belongs to Triazoles compound, is a common compound. In a patnet, author is Ammazzalorso, Alessandra, once mentioned the new application about 1704-62-7.

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors

In the search for novel aromatase inhibitors, a series of triazole and imidazole-based carbamate derivatives were designed and synthesized. Final compounds were thus evaluated against human aromatase by in vitro kinetic experiments in a fluorimetric assay in comparison with letrozole. The effect of most active derivatives 13a and 15c was then evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release) and cell cycle analysis, revealing a dose-dependent inhibition profile of cell viability and low micromolar IC50 values. In addition, docking simulations were also carried out to elucidate at a molecular level of detail the binding modes adopted to target human aromatase. (C) 2020 Elsevier Masson SAS. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1704-62-7 help many people in the next few years. Formula: C6H15NO2.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: Cyclobutane-1,1-dicarboxylic acid, 5445-51-2, Name is Cyclobutane-1,1-dicarboxylic acid, molecular formula is C6H8O4, belongs to Triazoles compound. In a document, author is Kumar, Rakesh, introduce the new discover.

Novel 1-Triazolylpyranopyrazoles as Highly Potent Anticancer Agents Obtained via MW-Assisted Synthesis

A series of novel 1-triazolylpyranopyrazole derivatives has been designed and synthesized using microwave irradiation, with the purpose of obtaining repositioned pharmaceutics. The newly synthesized 1-triazolylpyranopyrazoles (7 a-7 n), along with their precursor alkyne (5), have been screened for their in-vitro anti-tumor activity against Hep3B and HEK cell lines. The majority of triazolylpyranopyrazoles elicited outstanding anti-cancer activity on Hep3B cell lines even at concentrations as low as 25 mu g/mL. Further, molecular docking of these active compounds against Topoisomerase IIa substantiated a plausible target site for the compounds inhibiting Hep3B cells effectively. The biological assay results for the triazolylpyranopyrazole even surpassed the activity of the reference drug i. e. Doxorubicin, thereby appearing to be potent anticancer agents.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5445-51-2. Name: Cyclobutane-1,1-dicarboxylic acid.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5117-12-4, Name is 4-Acryloylmorpholine, molecular formula is C7H11NO2. In an article, author is Ciupak, Olga,once mentioned of 5117-12-4, Application In Synthesis of 4-Acryloylmorpholine.

New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives

In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 mu M concentration. Furthermore, to verify whether the obtained STS inhibitors are able to pass through the cellular membrane effectively, cell line experiments have been carried out. We found that the lowest STS activities were measured in the presence of compound 3L (remaining STS activity of 5.22%, 27.48% and 99.0% at 100, 10 and 1 nM concentrations, respectively). The measured STS activities for Irosustat (used as a reference) were 5.72%, 12.93% and 16.83% in the same concentration range. Moreover, a determined IC50 value of 15.97 nM for 3L showed that this compound is a very promising candidate for further preclinical investigations.

Interested yet? Keep reading other articles of 5117-12-4, you can contact me at any time and look forward to more communication. Application In Synthesis of 4-Acryloylmorpholine.

Chemistry is an experimental science, Application In Synthesis of 1,1,1-Tris(hydroxymethyl)ethane, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 77-85-0, Name is 1,1,1-Tris(hydroxymethyl)ethane, molecular formula is C5H12O3, belongs to Triazoles compound. In a document, author is Zhang, Daquan.

Anti-corrosion performance of covalent layer-by-layer assembled films via click chemistry reaction on the copper surface

Constructing the films with remarkable anti-corrosion performance is the key issue to metal protection. A kind of covalent layer-by-layer (LbL) assembly films of triazole is fabricated on the copper surface in this work. The covalent LbL system provides a promising and efficient protection. The optimum assembly layers are three and the best protection efficiency is 96.9 %. Enhancement in corrosion resistance is due to the formation of the covalent triazole films via the click chemistry reaction catalysed by cuprous oxide. The mechanism of protection is discussed via the surface analysis and the molecular dynamics simulation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 77-85-0, in my other articles. Application In Synthesis of 1,1,1-Tris(hydroxymethyl)ethane.

Synthetic Route of 77-85-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 77-85-0, Name is 1,1,1-Tris(hydroxymethyl)ethane, SMILES is CC(CO)(CO)CO, belongs to Triazoles compound. In a article, author is Bustos-Terrones, Victoria, introduce new discover of the category.

Revealing the anti-corrosion mechanism of fluconazole by experimental and theoretical studies

Through techniques such as electrochemical impedance spectroscopy and open circuit potential, the protective behavior of fluconazole against the mild steel corrosion process in neutral medium was evaluated. Best-fitted adsorption isotherm was the Frumkin model respect to Langmuir, which implies a multilayer protective film formation with lateral attraction between the adsorbed inhibitor molecules on mild steel surface. To document the protective mechanism, DFT computations and QTAIM analysis were carried out. The results, showed that the stability of the protection film is attributed to the flu-flu and flu-water clusters formation which, are stabilized by O-H center dot center dot center dot N, O-H center dot center dot center dot O, C-H center dot center dot center dot N, C-H center dot center dot center dot O, C-H center dot center dot center dot F hydrogen bonds, as well as p-stacking. Altogether, the results reported here suggest that the fluconazole is adsorbed on the metal surface demonstrating that electrostatic interactions are the most relevant in the corrosion process.

Synthetic Route of 77-85-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 77-85-0 is helpful to your research.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 464-48-2, Name is (-)-Camphor, molecular formula is C10H16O. In an article, author is Pham, Kevin M.,once mentioned of 464-48-2, Application In Synthesis of (-)-Camphor.

Ester modification at the 3 ‘ end of anti-microRNA oligonucleotides increases potency of microRNA inhibition

MicroRNAs (miRNAs) are short noncoding RNAs that play a fundamental role in gene regulation. Deregulation of miRNA expression has a strong correlation with disease and antisense oligonucleotides that bind and inhibit miRNAs associated with disease have therapeutic potential. Current research on the chemical modification of anti-miRNA oligonucleotides (anti-miRs) is focused on alterations of the phosphodiester-ribose backbone to improve nuclease resistance and binding affinity to miRNA strands. Here we describe a structure-guided approach for modification of the 3′-end of anti-miRs by screening for modifications compatible with a nucleotide-binding pocket present on human Argonaute-2 (hAgo2). We computationally screened a library of 190 triazole-modified nucleoside analogs for complementarity to the t1A-binding pocket of hAgo2. Seventeen top scoring triazoles were then incorporated into the 3′ end of anti-miR21 and potency was evaluated for each in a cell-based assay for anti-miR activity. Four triazole-modified anti-miRs showed higher potency than anti-miR21 bearing a 3′ adenosine. In particular, a triazole-modified nucleoside bearing an ester substituent imparted a ninefold and five-fold increase in activity for both anti-miR21 and anti-miR122 at 300 and 5 nM, respectively. The ester group was shown to be critical as a similar carboxylic acid and amide were inactive. Furthermore, anti-miR 3′ end modification with triazole-modified nucleoside analogs improved resistance to snake venom phosphodiesterase, a 3’-exonuclease. Thus, the modifications described here are good candidates for improvement of anti-miR activity.

Interested yet? Keep reading other articles of 464-48-2, you can contact me at any time and look forward to more communication. Application In Synthesis of (-)-Camphor.

Electric Literature of 1704-62-7, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 1704-62-7, Name is 2-(2-(Dimethylamino)ethoxy)ethanol, SMILES is CN(CCOCCO)C, belongs to Triazoles compound. In a article, author is Xue, Zhen-Zhen, introduce new discover of the category.

Novel silver(I) cluster-based coordination polymers as efficient luminescent thermometers

By employing a triazole-pyridine-containing ligand, two novel coordination polymers with Ag(I) clusters exhibiting different architectures have been successfully constructed. Structural analysis indicates that diverse coordination modes of the N-donor linker are responsible for the network difference for these two compounds, affording an isolated cluster for 1 and a 2D framework for 2, respectively. Compound 1 features a butterfly-shaped [Ag-8(bptp)(4)(H2O)(2)] cluster wherein strong argentophilic interactions could be observed. The linkage of Ag(I) with N and I centers gives rise to a tetranuclear building unit [Ag-4(bptp)(3)I] in 2, which is further extended to a 2D network with the assistance of the N-donor linkers. The syntheses and crystal structures have been investigated. Solid-state photoluminescence emissions as well as luminescence lifetimes of 1 and 2 have also been studied. Moreover, temperature-dependent luminescence tests show that an excellent linear relationship between temperature and emission intensity in the ranges of 77-298 K and 77-200 K could be observed for compounds 1 and 2, respectively. The wide temperature sensing range especially for 1 implies that they could act as promising ratiometric fluorescence molecular thermometers.

Electric Literature of 1704-62-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1704-62-7.