Tag: M.W=100-150

Vereshchagin, L. I. published the artcileSynthesis of polynuclear heterocyclic polynitrogen systems based on cyanuric chloride and its derivatives, Formula: C2H2N4O2, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2010), 46(2), 206-211, database is CAplus.

Polynuclear structures containing several heterocycles of various types were synthesized by the reaction of cyanuric chloride and its mono- and dichloro derivatives with triazoles and tetrazoles in the presence of bases.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C15H14Cl2S2, Formula: C2H2N4O2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Shevelev, S. A. published the artcileInteraction of NH-azoles with O-fluorosulfonyl-N,N-difluorohydroxylamine. Synthesis of N-fluorosulfonylazoles, Formula: C2H2N4O2, the publication is Izvestiya Akademi Nauk, Seriya Khimicheskaya (1992), 2419-30, database is CAplus.

FSO₂ONF₂ (I) reacts with anions of NH-azoles (imidazoles, pyrazoles, 1,2,3-triazoles) yielding the corresponding N-fluorosulfonylazoles from which sulfonylbisazoles are obtained. N-Fluorosulfonylation occurs at nitrogen atom which is farthest from the most electron-accepting substituent. Anions of nonaromatic NH-acids (imides, primary N-nitramines) can undergo N-fluorosulfonylation, however the yield is low (<5%) and the products are significantly less stable than N-fluorosulfonylazoles. N-Fluorosulfonylation occurs as nucleophilic substitution at the sulfur atom of I.

Izvestiya Akademi Nauk, Seriya Khimicheskaya published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C17H14F3N3O2S, Formula: C2H2N4O2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Shevelev, Svyatoslav A. published the artcileInteraction of NH-azoles with O-fluorosulfonyl-N,N-difluorohydroxylamine, Quality Control of 84406-63-3, the publication is Mendeleev Communications (1993), 14-15, database is CAplus.

O-Fluorosulfonyl-N,N-difluorohydroxylamine reacted with NH-azoles, pyrazoles, imidazoles and benzotriazole, in an alk. medium, affording the corresponding N-fluorosulfonylazoles, e.g., I (R = H, Cl, NO₂), and in certain cases also the products of their further reactions, N,N‘-sulfonylbisazoles, II (R = Cl, NO₂).

Mendeleev Communications published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C17H14F3N3O2S, Quality Control of 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Dharuman, Suresh published the artcileSynthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against Escherichia coli, Application In Synthesis of 59032-27-8, the publication is Molecules (2022), 27(5), 1518, database is CAplus and MEDLINE.

Infections due to Gram-neg. bacteria are increasingly dangerous due to the spread of multi-drug resistant strains, emphasizing the urgent need for new antibiotics with alternative modes of action. Authors have previously identified a novel class of antibacterial agents, thioacetamide-triazoles, using an antifolate targeted screen and determined their mode of action which is dependent on activation by cysteine synthase A. Herein, authors report a detailed examination of the anti-E. coli structure-activity relationship of the thioacetamide-triazoles. Analogs of the initial hit compounds were synthesized to study the contribution of the aryl, thioacetamide, and triazole sections. A clear structure-activity relationship was observed generating compounds with excellent inhibition values. Substitutions to the aryl ring were generally best tolerated, including the introduction of thiazole and pyridine heteroaryl systems. Substitutions to the central thioacetamide linker section were more nuanced; the introduction of a Me branch to the thioacetamide linker substantially decreased antibacterial activity, but the isomeric propionamide and N-benzamide systems retained activity. Changes to the triazole portion of the mol. dramatically decreased the antibacterial activity, further indicating that 1,2,3-triazole is critical for potency. From these studies, authors have identified new lead compounds with desirable in-vitro ADME properties and in-vivo pharmacokinetic properties.

Molecules published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application In Synthesis of 59032-27-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Maiorana, Stefano published the artcileEnamines. Reactions of sulfonyl- and nitroenamines with azides, Recommanded Product: 5-Nitro-1H-1,2,3-triazole, the publication is Tetrahedron Letters (1966), 6043-5, database is CAplus.

The reaction of aryl azides with enamines containing an SO2Ph, SO2C6H4NO2, or NO2 function in the β-position to the N atom was investigated. Treatment of ClCH:CHSO2Ph and p-O2NC6H4SO2CH:CHCl with morpholine gave the sulfonylenamines β-morpholinovinyl phenyl sulfone (I), m. 158°, and β-morpholinovinyl 4-nitrophenyl sulfone (II). PhN3 and 1-morpholino-2-nitroethylene (III) kept several days at 80° in a sealed tube, and then heated 5 days in refluxing EtOH containing 4-O2NC6-H4N3 gave 1-phenyl-4-nitrotriazole (IV), m. 134°, and 1-(4-nitrophenyl)-4-nitrotriazole, m. 201-2°. IV was catalytically hydrogenated to the corresponding 1-phenyl-4-aminotriazole, m. 108°. The enamines I, II, III refluxed 12-24 hrs. in alc. with p-MeC6H4SO2N3 yielded 50-80% 4-phenylsulfonyltriazole, m. 166°; 4-(p-nitrophenylsulfonyl)triazole (V), m. 212°; and 4-nitrotriazole, m. 158°, soluble in H2O giving a solution with Ka 1.6 × 10-5 at 20°. Neither diazo compounds nor amidine derivatives could be isolated.

Tetrahedron Letters published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Recommanded Product: 5-Nitro-1H-1,2,3-triazole.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Kizhnyaev, V. N. published the artcileSynthesis of energetic polynuclear and polymeric nitroazole systems, Quality Control of 14544-45-7, the publication is Russian Journal of Applied Chemistry (2009), 82(10), 1769-1775, database is CAplus.

Interaction of cyanuric chloride and its mono and dichloro derivatives with ammonium or sodium 4-nitro-1,2,3-triazolates and polymer-analogous transformations of tetrazole-containing polymers were used to synthesize polynuclear systems and macromol. compounds with heterocyclic structures bearing explosophoric groups.

Russian Journal of Applied Chemistry published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Quality Control of 14544-45-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Kizhnyaev, V. N. published the artcileSynthesis of N-Vinyl-1,2,3-triazole Derivatives, SDS of cas: 84406-63-3, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2002), 38(7), 1056-1059, database is CAplus.

Nitro-substituted N-vinyl-1,2,3-triazole derivatives were synthesized by the vinyl exchange reaction. The process was promoted by the catalytic system Hg(II) acetate-HO₂CCF₃. This system is universal, and it can be used in the synthesis of vinylazoles having two, three, and four N atoms in the ring.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C2H2N4O2, SDS of cas: 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Keshavarz, Mohammad Hossein published the artcileNovel correlation for predicting impact sensitivity of nitroheterocyclic energetic molecules, HPLC of Formula: 84406-63-3, the publication is Journal of Hazardous Materials (2007), 141(3), 803-807, database is CAplus and MEDLINE.

A correlation is introduced for predicting impact sensitivity of a variety nitroheterocyclic mol. types, such as nitropyridines, nitroimidazoles, nitropyrazoles, nitrofurazanes, nitrotriazoles and nitropyrimidines. This approach is based on elemental composition and 2 structural parameters of C_aH_bN_cO_d nitroheterocyclic energetic compounds The results for mentioned compounds are compared with complex neural networks computations which use compositional and topol. descriptors. Root mean square (rms) of deviation of different nitroheterocyclic mols. including nitropyridines, nitroimidazoles, nitropyrazoles, nitrofurazanes, nitrotriazoles and nitropyrimidines are 58 and 71 cm for new correlation and neural networks computations methods, resp.

Journal of Hazardous Materials published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C2H2N4O2, HPLC of Formula: 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Monn, James A. published the artcileSynthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu₂ Receptor Agonist, Application of Sodium 1,2,3-triazole-5-thiolate, the publication is Journal of Medicinal Chemistry (2015), 58(18), 7526-7548, database is CAplus and MEDLINE.

Identification of orthosteric mGlu_2/3 receptor agonists capable of discriminating between individual mGlu₂ and mGlu₃ subtypes has been highly challenging owing to the glutamate-site sequence homol. between these proteins. Herein we detail the preparation and characterization of a series of mols. related to (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) bearing C4-thiotriazole substituents. On the basis of second messenger responses in cells expressing other recombinant human mGlu_2/3 subtypes, a number of high potency and efficacy mGlu₂ receptor agonists exhibiting low potency mGlu₃ partial agonist/antagonist activity were identified. From this, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY2812223, I) was further characterized. Cocrystn. of I with the amino terminal domains of hmGlu₂ and hmGlu₃ combined with site-directed mutation studies has clarified the underlying mol. basis of this unique pharmacol. Evaluation of I in a rat model responsive to mGlu₂ receptor activation coupled with a measure of central drug disposition provides evidence that this mol. engages and activates central mGlu₂ receptors in vivo.

Journal of Medicinal Chemistry published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application of Sodium 1,2,3-triazole-5-thiolate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Golobokova, T. V. published the artcileSynthesis of N-(oxyran-2-ylmethyl)triazoles and -tetrazoles, SDS of cas: 84406-63-3, the publication is Russian Journal of Organic Chemistry (2015), 51(9), 1308-1312, database is CAplus.

The alkylation of 5-phenyl-1H-tetrazole and 4-nitro-2H-1,2,3-triazole with 1-chloro-2,3-epoxypropane and cycloaddition of 1-azido-3-chloropropan-2-ol to acetylenic dipolarophiles gave the corresponding N-(3-chloro-2-hydroxypropyl)azoles as intermediate products in the synthesis of N-(oxiran-2-ylmethyl)azoles.

Russian Journal of Organic Chemistry published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C2H2N4O2, SDS of cas: 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics