Tag: M.W=0-100

Nagarkoti, S; Dubey, M; Sadaf, S; Awasthi, D; Chandra, T; Jagavelu, K; Kumar, S; Dikshit, M in [Nagarkoti, Sheela; Dubey, Megha; Sadaf, Samreen; Awasthi, Deepika; Jagavelu, Kumaravelu; Kumar, Sachin] Cent Drug Res Inst, CSIR, Pharmacol Div, Lucknow, Uttar Pradesh, India; [Chandra, Tulika] King Georges Med Univ, Lucknow, Uttar Pradesh, India; [Dikshit, Madhu] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, THSTI Natl Chair, 3rd Milestone,Faridabad Gurgaon Expressway, Faridabad 121001, Haryana, India published Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival in 2019.0, Cited 70.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death. On the contrary, introducing reducing environment by TCEP rescued catalase activity and significantly improved neutrophil survival. Furthermore, augmentation in ROS generation by NOX-2 activation or induction of mitochondrial ROS by Antimycin-A induced catalase S-glutathionylation and cell death, which was prevented in the neutrophil cytosolic factor1 (NCF-1-/-) cells or was rescued by MitoTEMPO, a mitochondrial ROS scavenger, thus, suggesting a correlation between catalase S-glutathionylation/activity inhibition and reduced neutrophil survival. Altogether, enhanced NOX2 activation/mitochondrial dysfunction led to reduced survival of human and mice neutrophils, due to H2O2 accumulation, S-glutathionylation of catalase, and reduction in its enzymatic activity. The present study thus demonstrated mitigation of catalase activity under oxidative stress-impacted neutrophil survival.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants WOS:000608522800010 published article about CARRIER PROTEIN; ARABIDOPSIS; SPINACH; LIGHT; BIOSYNTHESIS; WRINKLED1; COENZYME; PHOSPHORYLATION; ACCUMULATION; GENES in [Ye, Yajin; Fedosejevs, Eric T.; Van Doren, Steven R.; Thelen, Jay J.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Biochem, 1201 E Rollins, Columbia, MO 65211 USA; [Nikovics, Krisztina; To, Alexandra; Lepiniec, Loic; Baud, Sebastien] Univ Paris Saclay, AgroParisTech, Inst Jean Pierre Bourgin, INRAE,CNRS, F-78000 Versailles, France in 2020.0, Cited 60.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully understood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains. We report here the identification of a gene family encoding for three small plastidial proteins of the envelope membrane that interact with the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechanism restraining FAS in the light. Light enhances the interaction between carboxyltransferase interactors (CTIs) and alpha-CT, which in turn attenuates carbon flux into FAS. Knockouts for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in leaves, more than 4-fold higher than in wild-type plants. Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regulates CTI1 expression by direct binding to its promoter. This study reveals that in addition to light-dependent activation, envelope docking of ACCase permits fine-tuning of fatty acid supply during the plant life cycle.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Recently I am researching about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Fahim, AM; Shalaby, MA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S in [Wang, Xu; Ma, Biao; Wang, Yating; Lu, Songyan; Ma, Meng; Shi, Yanqin; Chen, Si] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China published A new theory of two-step stabilization mechanism for triazole-based zinc-containing complex as thermal stabilizer for polyvinyl chloride) in 2019.0, Cited 31.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A totally new theory of two-step stabilization mechanism for triazole-based zinc-containing complex (abbreviated as (Zn(ttr)(OAc)]) was proposed through several designed experiments. [Zn(ttr)(OAc)] strongly absorbed HCl at the beginning, and then broke down into 3-amino-1,2,4-triazole which could further stabilized PVC. The structure of [Zn(ttr)(OAc)] was characterized by FTIR spectroscopy, elemental analysis and SEM. Then, Congo red tests and discoloration tests verified [Zn(ttr)(OAc)] could absorb HCl effectively, but PVC showed poor initial whiteness, which further proved above -mentioned stabilization mechanism. Moreover, [Zn(ttr)(OAc)] combined with ZnSt(2) and dibenzoyl methane (DBM) effectively improved the initial color of PVC samples and provided PVC with shorter plasticizing time and longer dynamic thermal stability time than commercial stabilizer 1086F, confirmed by discoloration tests and dynamic thermal stability analysis. We believe [Zn(ttr)(OAc)]/ZnSt(2)/DBM stabilizer system can be used as a commercial stabilizer and the stabilization mechanism of [Zn(ttr)(OAc)] may provide a new way to stabilize PVC. (C) 2019 Published by Elsevier Ltd.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Preparation and characterization of a novel DABCO-based ionic liquid supported on Fe3O4@TiO(2)nanoparticles and investigation of its catalytic activity in the synthesis of quinazolinones published in 2020.0. Name: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Ghasemzadeh, MA (corresponding author), Islamic Azad Univ, Qom Branch, Dept Chem, Qom, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In this study, quinazolinone derivatives have been synthesized via a suitable and efficient procedure by one-potmulti-component reactions of 3-amino-1,2,4-triazole or 2-aminobenzimidazole, dimedone and aromatic aldehydes in the presence of Fe3O4@TiO2-IL as nanocatalyst under solvent-free condition. The products were prepared in good to excellent yields using Fe3O4@TiO2-IL magnetic nanocatalyst. The Fe3O4@TiO(2)magnetic nanoparticles (MNPs) were prepared using beet juice extract and functionalized with IL based on DABCO. Moreover, the core-shell structured magnetic Fe3O4@TiO2-IL has been characterized by different techniques such as(1)H-NMR, FT-IR, VSM, XRD, SEM, TGA, TEM and EDX. To the best of our knowledge, the prepared ionic liquid displayed a good protective and activator agent for magnetic nanocatalyst.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB in [Zurlinden, Todd J.; Saili, Katerine S.; Knudsen, Thomas B.] US EPA, Off Res & Dev, Ctr Computat Toxicol & Exposure, Res Triangle Pk, NC USA; [Baker, Nancy C.] Leidos, Alexandria, VA USA; [Toimela, Tarja; Heinonen, Tuula] Tampere Univ, Fac Med & Hlth Technol, FICAM, Tampere, Finland published A cross-platform approach to characterize and screen potential neurovascular unit toxicants in 2020.0, Cited 79.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in formation of the blood-brain barrier. Typical high-throughput screening (HTS) assays investigate single biochemical or single cell responses following chemical insult. As the NVU comprises multiple cell types interacting at various stages of development, a methodology combining high-throughput results across pertinent cell-based assays is needed to investigate potential chemical-induced disruption to the development of this complex cell system. To this end, we implemented a novel method for screening putative NVU disruptors across diverse assay platforms to predict chemical perturbation of the developing NVU. HTS assay results measuring chemical-induced perturbations to cellular key events across angiogenic and neurogenic outcomes in vitro were combined to create a cell-based prioritization of NVU hazard. Chemicals were grouped according to similar modes of action to train a logistic regression literature model on a training set of 38 chemicals. This model utilizes the chemical-specific pairwise mutual information score for PubMed MeSH annotations to represent a quantitative measure of previously published results. Taken together, this study presents a methodology to investigate NVU developmental hazard using cell-based HTS assays and literature evidence to prioritize screening of putative NVU disruptors towards a knowledge-driven characterization of neurovascular developmental toxicity. The results from these screening efforts demonstrate that chemicals representing a range of putative vascular disrupting compound (pVDC) scores can also produce effects on neurogenic outcomes and characterizes possible modes of action for disrupting the developing NVU.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wiench, P; Gonzalez, Z; Gryglewicz, S; Menendez, R; Gryglewicz, G in [Wiench, Piotr; Gryglewicz, Stanislaw; Gryglewicz, Grazyna] Wroclaw Univ Sci & Technol, Fac Chem, Dept Polymer & Carbonaceous Mat, Gdanska 7-9, PL-50344 Wroclaw, Poland; [Gonzalez, Zoraida; Menendez, Rosa] CSIC, Inst Nacl Carbon INCAR, Francisco Pintado Fe 26, Oviedo 33011, Spain published Enhanced performance of pyrrolic N-doped reduced graphene oxide-modified glassy carbon electrodes for dopamine sensing in 2019.0, Cited 60.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Two different nitrogen-doped reduced graphene oxides (N-rGOs) were used to modify glassy carbon electrodes (GCE/N-rGOs) as electrochemical sensors for the detection of dopamine (DA). For comparison, GCE/rGO was also studied. The N-rGOs were synthesized via hydrothermal treatment of graphene oxide (GO) with the N-dopants amitrole and urea. The resultant graphene materials exhibited distinct types and distributions of nitrogenated functional groups, but they possessed a similar oxygen content, thus avoiding interference from oxygenated groups. Pyridinic nitrogen was introduced into the rGO structure when amitrole was used as the N-dopant, whereas pyrrolic nitrogen was preferentially formed in the reaction with urea. After optimization of several experimental parameters and sensor calibration, the GCE/pyrrolic-N-rGO electrode was found to exhibit superior electrochemical performance compared with the pyridinic-N-rGO one, demonstrating a limit of detection and sensitivity of 335 nM and 3.51 mu A mu M-1, respectively. This sensor also showed better selectivity in the presence of interfering agents in the forms of ascorbic and uric acids. A significant improvement of sensor parameters can be explained in terms of the contribution of electrons derived from the pyrrolic structure to the delocalized C sp(2)-conjugated graphene system.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Wiench, P; Gonzalez, Z; Gryglewicz, S; Menendez, R; Gryglewicz, G or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 FLUID PHASE EQUILIBR published article about GREEN; MIXTURES; PARACETAMOL; IBUPROFEN in [Seyf, Jaber Yousefi] Hamedan Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran; [Asgari, Mohammad] Sharif Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran in 2020.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Name: 1H-1,2,4-Triazol-5-amine

The recently reported UNIversal QUAsiChemical Segment Activity coefficient (UNIQUAC-SAC) model [developed by Haghtalab and Yousefi Seyf Ind. Eng. Chem. Res. 2015, 54, 8611] provides a practical thermodynamic framework to be used in VLE, LLE, and SLE calculations. The UNIQUAC-SAC model has the advantage of being independent of area (q) and volume (r) structural parameters used in the combinatorial part. While the UNIFAC or UNIFAC-DMD could not apply to the 47% (44 of 94) of the studied molecules because of the undefined groups. Here, the numbers of solvents with identified segment numbers were extended from 82 to 130 with a slight refinement to the previous values. The model parameters obtained via a large consistent set of VLE (isobaric and isothermal), and LLE experimental data. Also, the model was tested with pharmaceutical solubility experimental data in pure (94 solutes with 6210 solubility data), binary, and ternary solvents. The model provides a robust correlation of pharmaceuticals solubility in a mono-solvent and robust prediction of pharmaceuticals solubility in mixed solvents. The UNIQUAC-SAC model was successfully evaluated in solvent screening in cooling crystallization of ibuprofen and valsartan in both pure and binary solvents mixture (combined cooling and anti-solvent crystallization). The model with 130 solvents as a robust database provides a useful and practical thermodynamic tool in the conceptual design of pharmaceutical processes. A MATLAB based graphical user interface (GUI), finally, was developed to be used in the conceptual segment numbers regression procedure. (C) 2020 Elsevier B.V. All rights reserved.

Name: 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. Kolodziej, B; Morawiak, M; Schilf, W; Kamienski, B in [Kolodziej, Beata] West Pomeranian Univ Technol, Fac Chem Technol & Engn, Dept Inorgan & Analyt Chem, Al Piastow 42, PL-71065 Szczecin, Poland; [Morawiak, Maja; Schilf, Wojciech; Kamienski, Bohdan] Polish Acad Sci, Inst Organ Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Kamienski, Bohdan] Polish Acad Sci, Inst Phys Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland published Structure investigations of Schiff bases derived from 3-amino-1H-1,2,4-triazole in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In the present paper, twelve Schiff bases derived from 3-amino-1H-1,2,4-triazole (ATz) and various benzaldehydes, and salicylaldehydes were synthesized. The H-1, C-13, and N-15 NMR data are discussed in relation to the structure of ATz and its imine products. In addition, X-ray, ATR-FTIR, and UV-Vis analytical techniques are used for structure elucidation of ATz-based Schiff bases. It was found that the starting material, 3-amino-1H-1,2,4-triazole, exists as tautomeric mixture of three forms (Graphical Abstract) in solution, whereas in the solid state (C-13 and N-15 CPMAS data) potentially tautomeric proton is located on nitrogen atom traditionally marked as N-2 (Graphical Abstract, 2N-H structure). All investigated Schiff bases derived from salicylaldehydes exist in both phases as tautomeric equilibrium mixtures, where enol-imine forms are dominated structures. The positions of those equilibria only very slightly depend on substituents in phenol ring. Generally, the contributions of keto-amine forms in the solid state are higher comparing with DMSO solutions. (C) 2019 Published by Elsevier B.V.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Engineering; Environmental Sciences & Ecology very interesting. Saw the article Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction published in 2020.0. COA of Formula: C2H4N4, Reprint Addresses Ekins, S (corresponding author), Collaborat Pharmaceut Inc, Raleigh, NC 27606 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The U.S. Environmental Protection Agency (EPA) periodically releases in vitro data across a variety of targets, including the estrogen receptor (ER). In 2015, the EPA used these data to construct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrine disruption testing. However, mathematical models require in vitro data prior to predicting estrogenic activity, but machine learning methods are capable of prospective prediction from the molecular structure alone. The current study describes the generation and evaluation of Bayesian machine learning models grouped by the EPA’s ER agonist pathway model using multiple data types with proprietary software, Assay Central. External predictions with three test sets of in vitro and in vivo reference chemicals with agonist activity classifications were compared to previous mathematical model publications. Training data sets were subjected to additional machine learning algorithms and compared with rank normalized scores of internal five-fold cross-validation statistics. External predictions were found to be comparable or superior to previous studies published by the EPA. When assessing six additional algorithms for the training data sets, Assay Central performed similarly at a reduced computational cost. This study demonstrates that machine learning can prioritize chemicals for future in vitro and in vivo testing of ER agonism.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S or send Email.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics