Tag: M.W=0-100

In 2020.0 J HETEROCYCLIC CHEM published article about ONE-POT SYNTHESIS; ASSISTED SYNTHESIS; REARRANGEMENT; HETEROCYCLES in [Kassem, Asmaa F.; Abbas, Eman M. H.] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Chem Nat & Microbial Prod Dept, 33 Bohouth St,POB 12622, Giza, Egypt; [Al-Qurashi, Nadia T.] Umm Al Qura Univ, Univ Coll Adam, Dept Basic Sci, Mecca, Almukkarramah, Saudi Arabia; [Farghaly, Thoraya A.] Cairo Univ, Fac Sci, Dept Chem, Giza 1263, Egypt; [Farghaly, Thoraya A.] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca 21514, Almukkarramah, Saudi Arabia in 2020.0, Cited 28.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

With aiding of microwave radiation, new series of fused-thiazolopyrimidines and fused-triazolopyrimidines each with cycloheptane have been synthesized through the reaction of cycloheptane-thione with alpha-haloketones or hydrazonoyl chlorides in short-time intervals as well as high yield. Moreover, reaction of 2,7-bis(2-chlorobenzylidene)cycloheptan-1-one with o-aminothiophenol and heterocyclic amines afforded benzo[b]cyclohepta[e][1,4]thiazepine derivative and cycloheptapyrimidines fused with different azoles, respectively. The structure for all products was discussed and proved based on the results of spectral data and elemental analysis. Evaluation of the antimicrobial activity of selected products indicated that most of derivatives showed their potent activity exceeds the reference antibiotic in some cases.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Kassem, AF; Abbas, EMH; Al-Qurashi, NT; Farghaly, TA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Enhanced performance of pyrrolic N-doped reduced graphene oxide-modified glassy carbon electrodes for dopamine sensing WOS:000500386400013 published article about ELECTROCHEMICAL SENSOR; ASCORBIC-ACID; NITROGEN; FABRICATION; REDUCTION; NANOPARTICLES; HYDRAZINE; COMPOSITE; OXYGEN; HYBRID in [Wiench, Piotr; Gryglewicz, Stanislaw; Gryglewicz, Grazyna] Wroclaw Univ Sci & Technol, Fac Chem, Dept Polymer & Carbonaceous Mat, Gdanska 7-9, PL-50344 Wroclaw, Poland; [Gonzalez, Zoraida; Menendez, Rosa] CSIC, Inst Nacl Carbon INCAR, Francisco Pintado Fe 26, Oviedo 33011, Spain in 2019.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Two different nitrogen-doped reduced graphene oxides (N-rGOs) were used to modify glassy carbon electrodes (GCE/N-rGOs) as electrochemical sensors for the detection of dopamine (DA). For comparison, GCE/rGO was also studied. The N-rGOs were synthesized via hydrothermal treatment of graphene oxide (GO) with the N-dopants amitrole and urea. The resultant graphene materials exhibited distinct types and distributions of nitrogenated functional groups, but they possessed a similar oxygen content, thus avoiding interference from oxygenated groups. Pyridinic nitrogen was introduced into the rGO structure when amitrole was used as the N-dopant, whereas pyrrolic nitrogen was preferentially formed in the reaction with urea. After optimization of several experimental parameters and sensor calibration, the GCE/pyrrolic-N-rGO electrode was found to exhibit superior electrochemical performance compared with the pyridinic-N-rGO one, demonstrating a limit of detection and sensitivity of 335 nM and 3.51 mu A mu M-1, respectively. This sensor also showed better selectivity in the presence of interfering agents in the forms of ascorbic and uric acids. A significant improvement of sensor parameters can be explained in terms of the contribution of electrons derived from the pyrrolic structure to the delocalized C sp(2)-conjugated graphene system.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sayed, GH; Azab, ME; Anwer, KE in [Sayed, Galal H.; Azab, Mohammad E.; Anwer, Kuris E.] Ain Shams Univ, Organ Chem Lab, Chem Dept, Fac Sci, Cairo 11566, Egypt published Conventional and Microwave-Assisted Synthesis and Biological Activity Study of Novel Heterocycles Containing Pyran Moiety in 2019.0, Cited 30.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Under both conventional and microwave methods, 2-amino-4H-pyran-3-carbonitrile derivative 1 was synthesized and reacted with different reagents. Thus, 2-amino-4H-pyran-3-carbonitrile derivative was treated with chloroacetyl chloride, phenyl isocyanate, cyanoacetic acid, benzoyl chloride, triethyl orthoformate, acetic anhydride/H2SO4, arylidene malononitrile, urea, and/or p-aminosulphaguanidine producing chloroacetamide, 3-phenylurea, cyanoacetamide, N-benzoylpyran, ethylformimidate, pyranopyrimidin-4-one, pyranopyridine, pyranopyrimidin-2-one, and pyranopyrimidin-2-imine derivatives, respectively. Meanwhile, compound 1 was reacted with ethyl bromoacetate, phenacyl bromide, phthalic anhydride, different aromatic amines, and/or acetic acid/H2SO4 to produce 5-aminopyrano[2,3-b]pyrrole-6-carboxylate, dihydropyrano[2,3-b]pyrrole-6-yl-(phenyl)methanone, 1,3-dioxoisoindolinyl pyran, 1,4-dihydropyridine, and 2-hydroxy-1,4-dihydropyridine derivatives, respectively. On the other hand, when compound 1 was allowed to react with maleic anhydride and/or hydrazine hydrate, pyran-4-oxobut-2-enoic acid and 3-aminopyranopyrazole derivatives were obtained, respectively. Reaction of pyran-4-oxobut-2-enoic acid with malononitrile under different conditions gave 2-(furan-2-yl)-4H-pyran and 2-(4H-pyran-2-yl)-1H-pyrrole derivatives, while condensation of 3-aminopyranopyrazole with benzaldehyde gave 1,4-dihydropyrano[2,3-c]pyrazol-3-yl-1-phenylmethanimine derivative. The newly synthesized compounds were characterized by the spectroscopic tools IR, H-1-NMR, C-13-NMR, MS, and elemental analysis. Some of these compounds have been screened in vitro for antimicrobial activity against different strains of bacteria and fungi and also were tested against two cancer cell lines: mammary gland breast cancer (MCF-7) and colon cancer (HCT-118).

Computed Properties of C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Sayed, GH; Azab, ME; Anwer, KE or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Plant Sciences; Cell Biology very interesting. Saw the article A Tetratricopeptide Repeat Protein Regulates Carotenoid Biosynthesis and Chromoplast Development in Monkeyflowers (Mimulus) published in 2020.0. SDS of cas: 61-82-5, Reprint Addresses Stanley, LE; Yuan, YW (corresponding author), Univ Connecticut, Dept Ecol & Evolutionary Biol, Storrs, CT 06269 USA.; Yuan, YW (corresponding author), Univ Connecticut, Inst Syst Genom, Storrs, CT 06269 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Little is known about the factors regulating carotenoid biosynthesis in flowers. Here, we characterized the REDUCED CAROTENOID PIGMENTATION2 (RCP2) locus from two monkeyflower (Mimulus) species, the bumblebee-pollinated species Mimulus lewisii and the hummingbird-pollinated species Mimulus verbenaceus. We show that loss-of-function mutations of RCP2 cause drastic down-regulation of the entire carotenoid biosynthetic pathway. The causal gene underlying RCP2 encodes a tetratricopeptide repeat protein that is closely related to the Arabidopsis (Arabidopsis thaliana) REDUCED CHLOROPLAST COVERAGE proteins. RCP2 appears to regulate carotenoid biosynthesis independently of RCP1, a previously identified R2R3-MYB master regulator of carotenoid biosynthesis. We show that RCP2 is necessary and sufficient for chromoplast development and carotenoid accumulation in floral tissues. Simultaneous down-regulation of RCP2 and two closely related paralogs, RCP2-L1 and RCP2-L2, yielded plants with pale leaves deficient in chlorophyll and carotenoids and with reduced chloroplast compartment size. Finally, we demonstrate that M. verbenaceus is just as amenable to chemical mutagenesis and in planta transformation as the more extensively studied M. lewisii, making these two species an excellent platform for comparative developmental genetics studies of closely related species with dramatic phenotypic divergence.

SDS of cas: 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, C; Gao, YT; Xia, XF; Zhu, JW; Wang, X; Fu, YS in [Li, Chun; Gao, Yanting; Xia, Xifeng; Zhu, Junwu; Wang, Xin; Fu, Yongsheng] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Peoples R China published Hierarchically Structured Two-Dimensional Bimetallic CoNi-Hexaaminobenzene Coordination Polymers Derived from Co(OH)(2) for Enhanced Oxygen Evolution Catalysis in 2020.0, Cited 68.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Conjugated coordination polymers (CPs) with designable and predictable structures have drawn tremendous attention in recent years. However, the poor electrical conductivity and low structural stability seriously restrict their practical applications in electronic devices. Herein, the rational design and synthesis of a hierarchically structured 2D bimetallic CoNi-hexaaminobenzene CPs derived from Co(OH)(2) are reported as an efficient oxygen evolution reaction (OER) self-supported electrode. The as-obtained electrode possesses high electrochemical surface area and intrinsic activity, exhibiting high electrochemical catalytic activity, favorable reaction kinetics performance, and strong durability compared with those of the powder catalysts. As a result, the electrode delivers low overpotential of 219 mV @ 10 mA cm(-2) and Tafel slope of 42 mV dec(-1) as well as 91.3% retention of current density after 24 h of reaction time. The results of density functional theory computations reveal that the synergistic effect of Co and Ni plays an important role in OER. This work not only presents a strategy to fabricate advanced self-supported electrodes with abundant and dense active sites, but also promotes the development of conjugated CPs for electrocatalysis.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, C; Gao, YT; Xia, XF; Zhu, JW; Wang, X; Fu, YS or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Wang, S; Ma, XB; Yuan, XH; Yu, B; Xu, YC; Liu, HM in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA published Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, S; Ma, XB; Yuan, XH; Yu, B; Xu, YC; Liu, HM or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Authors Kovygin, YA; Vandyshev, DY; Ledenyova, IV; Kosheleva, EA; Polikarchuk, VA; Kozaderov, OA; Shikhaliev, KS in SPRINGER published article about in [Kovygin, Yu A.; Vandyshev, D. Yu; Ledenyova, I., V; Kosheleva, E. A.; Polikarchuk, V. A.; Kozaderov, O. A.; Shikhaliev, Kh S.] Voronezh State Univ, 1 Univ Skaya Pl, Voronezh 394018, Russia in 2021.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A convenient method for the synthesis of 2-(2-R-5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the regioselective domino reaction of N-arylitaconimides with substituted 3-aminotriazoles was proposed. Presumably, the reaction pathway includes the conjugated aza-addition of the endo-nucleophilic center of triazole to imide, followed by the recyclization of the intermediate to triazolo[1,5-a]pyrimidine.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Chamber Protection of Copper from Atmospheric Corrosion by Compounds of the Triazole Class WOS:000603324200008 published article about SATURATED VAPOR-PRESSURE; BENZOTRIAZOLE; INHIBITION; IMPEDANCE; DERIVATIVES; PREDICTION; ADSORPTION; BEHAVIOR; KINETICS; FILMS in [Goncharova, O. A.; Luchkin, A. Yu; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 46.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (electrochemical impedance spectroscopy and polarization measurements), and corrosion (periodic moisture condensation and salt fog tests) methods, the properties of adsorption films formed on copper by the chamber method from vapors of benzotriazol (BTA), 1H-1,2,4-triazole, tolyltriazole (TTA), 5-chloro-1,2,3-benzotriazole (CBTA), 3-amino-1H-1,2,4-triazole, and 4-amino-1H-1,2,4-triazole at a temperature of 100 degrees C are studied. It is shown that 1-h chamber treatment of copper with vapors of these compounds leads to the formation of nanoscale hydrophobic adsorption films on it, which inhibits the thermal growth of oxides, but stabilizes the passive state of the metal and increases its corrosion resistance. Among these different triazole compounds tested as chamber corrosion inhibitors, BTA and its substituted derivatives are distinguished. After a 1-h chamber treatment of copper, the protective aftereffect of the adsorption films of triazole derivatives grows symbatically with their saturated vapor pressure at the chamber treatment temperature, i.e., in the following increasing order: CBTA < TTA < BTA. This may indicate that the equilibrium adsorption films do not have time to form at 100 degrees C on the metal within this time period. After a prolonged (24 h or more) chamber treatment of copper with vapors of substituted benzotriazoles, equilibrium adsorption films of inhibitors are formed on it. In this case, the influence of the chamber inhibitor properties on their protective aftereffect alternates. Under such conditions, the least volatile and most hydrophobic substituted benzotriazole, i.e., CBTA, provide the best metal protection. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ENERGETIC MATERIALS; DERIVATIVES; PYRAZOLE; DESIGN; DETONATIONS; PERFORMANCE; INHIBITORS; CHEMISTRY; FRAMEWORK; FAMILY, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21602241, 21975066]; Open Research Fund Program of Science and Technology on Aerospace Chemical Power Laboratory [STACPL120181B04]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Huang, HF; Shi, YM; Li, H; Li, HL; Pang, AM; Yang, J. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Formula: C2H4N4

Potassium 1,1,3,3-tetranitropropane-1,3-diide (K2TNP) was found to react readily with various (hetero)aryl amines (12 examples) to give corresponding N-(hetero)aryl-3,5-dinitropyrazoles in moderate to excellent yields. The reactions were performed at mild temperature, and most of the reactions completed in less than 4 h. Four potential energetic compounds show high enthalpy of formation, excellent thermal stability, and good sensitivity, with 3-(3,5-dinitropyrazol-1-yl)-1H-1,2,4-triazole (3j) being a potential 2,2′,4,4′,6,6′-hexanitrostibene (HNS) replacement.

Welcome to talk about 61-82-5, If you have any questions, you can contact Huang, HF; Shi, YM; Li, H; Li, HL; Pang, AM; Yang, J or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Bronsted acid-promoted ‘on-water’ C(sp(3))-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction WOS:000510956700009 published article about AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; MOLECULAR HYBRIDIZATION; EFFICIENT SYNTHESIS; DESIGN in [Yuan, Shuo; Wang, Sixi; Zhao, Min; Zhang, Danqing; Chen, Jinjie; Li, Jian-Xin; Zhang, Jingya; Song, Yihui; Wang, Jinyi; Yu, Bin; Liu, Hongmin] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics