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Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Authors Wang, JH; Chen, WZ; Wang, HY; Li, YD; Wang, B; Zhang, LX; Wan, XC; Li, M in ELSEVIER IRELAND LTD published article about in [Wang, Jinhe; Chen, Wenzhen; Wang, Hanyue; Li, Yuanda; Wang, Biao; Zhang, Lixia; Li, Min] Shandong Agr Univ, Coll Hort Sci & Engn, State Key Lab Crop Biol, Tai An 271018, Shandong, Peoples R China; [Wan, Xiaochun] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China in 2021.0, Cited 72.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Glutamine plays a critical role in ammonium assimilation, and contributes substantially to the taste and nutritional quality of tea. To date, little research has been done on glutamine synthesis in tea plants. Here, a zinc finger protein CsDOF and a glutamine synthetase (GS)-encoding gene CsGS2 from tea plant (Camellia sinensis cv ‘Shuchazao’) were characterized, and their role in glutamine biosynthesis was determined using transient suppression assays in tea leaves and overexpression in Arabidopsis thaliana. The expression patterns of CsDOF and CsGS2, the GS activity and the glutamine content of photosynthetic tissues (leaf and bud) were significantly induced by shade. Suppressing the expression of CsDOF resulted in downregulated expression of CsGS2 and reduction of the leaf glutamine content. Moreover, in CsDOF-silenced plants, the expression of CsDOF and the glutamine content under shade treatment were higher than in natural light. The glutamine content and CsGS2 transcript level were also decreased in tea leaves when CsGS2 was suppressed, while they were higher under shade treatment than in natural light in CsGS2-silenced plants. In addition, the glutamine content and GS2 transcript level were increased when CsDOF and CsGS2 was overexpressed in Arabidopsis thaliana, respectively. In binding analyses, CsDOF directly bound to an AAAG motif in the promoter of CsGS2, and promotes its activity. The study shed new light on the molecular mechanism by which CsDOF activates CsGS2 gene expression and contributes to glutamine biosynthesis in tea plants.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Chhetri, S; Ghosh, S; Samanta, P; Murmu, NC; Kuila, T or send Email.

Category: Triazoles. In 2019.0 CHEMISTRYSELECT published article about FUNCTIONALIZED GRAPHENE; CORROSION PROTECTION; GRAPHITE OXIDE; ENHANCEMENT; RESISTANCE; NANOSHEETS; INHIBITORS; ZIRCONIA; DELIVERY; CATALYST in [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] CSIR Cent Mech Enging Res Inst, Surface Engn & Tribol Div, Durgapur 713209, India; [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2019.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The present study explores the synergistic effect of Fe3O4 and heteroatom doped reduced graphene oxide (rGO) nanohybrid on anti-corrosion performance of epoxy composite coating. In this connection, Fe3O4 nanoparticles were decorated over nitrogen doped rGO (Fe3O4-NRG) and characterized by Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD), X-ray Photoelectron spectroscopy (XPS), and Thermogravimetric analysis (TGA). This approach to modulating the surface properties of graphene and hence the interaction with polymer matrix were quite distinct from traditional surface functionlization or decoration in a sense that the doped nitrogen atom facilitate the growth of Fe3O4 particles and at the same time augmented the interaction of rGO with polymer matrix. The prepared nanohybrid was dispersed in epoxy matrix through mechanical mixing and coated over mild steel surface via spin coating technique. The potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) study revealed superior anti-corrosion performance of Fe3O4-NRG/epoxy coating in 3.5 wt% NaCl solution. The corrosion inhibition was found to improve by similar to 98.5% with 0.5 wt% loading of Fe3O4-NRG. We believe that this simple solvent free approach to prepare composite coating can be exploit for practical application and thus deserves special attention..

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Chhetri, S; Ghosh, S; Samanta, P; Murmu, NC; Kuila, T or send Email.

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Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Feng, SQ; Li, AQ; Zuo, JH; Zhang, DQ; Xing, YJ; Xie, ZY; Yu, B; Liu, HM or send Email.

Formula: C2H4N4. Yuan, S; Feng, SQ; Li, AQ; Zuo, JH; Zhang, DQ; Xing, YJ; Xie, ZY; Yu, B; Liu, HM in [Yuan, Shuo; Feng, Si-Qi; Li, An-Qi; Zuo, Jia-Hui; Zhang, Dan-Qing; Xing, Yu-Jie; Yu, Bin; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Yuan, Shuo; Feng, Si-Qi; Li, An-Qi; Zuo, Jia-Hui; Zhang, Dan-Qing; Xing, Yu-Jie; Yu, Bin; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China; [Xie, Zhiyu] Xuchang Univ, Coll Chem & Mat Engn, 88 Bayi Rd, Xuchang 461000, Henan, Peoples R China published Design and synthesis of new indole containing biaryl derivatives as potent antiproliferative agents in 2021.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A new series of indole containing biaryl derivatives were designed and synthesized, and further biological evaluations of their antiproliferative activity against cancer cell lines (MGC-803 and TE-1 cells) were also conducted. Of these synthesized biaryls, compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl) methyl)quinazoline (23) performed as the most potent antiproliferative agent that inhibited cell viability of MGC-803 cells with an IC50 value of 8.28 mu M. In addition, investigation of mechanism exhibited that the compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)methyl)quinazoline (23) could inhibit the expression of c-Myc and glycolysis related proteins, decrease the ATP and lactate production, and further induce apoptosis by activating the AMP-activated protein kinase (AMPK) and p53 signaling pathways.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Feng, SQ; Li, AQ; Zuo, JH; Zhang, DQ; Xing, YJ; Xie, ZY; Yu, B; Liu, HM or send Email.

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SDS of cas: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Wei, YJ; Gao, J; Feng, Y; Wang, N; Gao, JF or send Email.

SDS of cas: 61-82-5. In 2019.0 NANO published article about EFFICIENT CARBOCATALYST; NANOPARTICLES; GRAPHENE; ACID; NANOSPHERES; PERFORMANCE; ELECTRODES; OXIDATION in [Zhou, Shenghai; Xu, Hongbo; Wei, Yanjun; Gao, Jing; Feng, Yue; Gao, Junfeng] Hebei Normal Univ Nationalities, Dept Chem & Chem Engn, Chengde 067000, Peoples R China; [Wang, Ning] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China in 2019.0, Cited 43.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Heteroatom-doped ordered mesoporous carbons (OMCs) have currently been considered as promising electrode materials for electrochemical sensors due to the combined advantages of ordered mesoporous materials and heteroatom-doped carbon materials. Herein, a novel nitrogen and sulfur co-doped OMCs (N,S-OMC) has been prepared via a nanocasting strategy with an inexpensive methylene blue as single precursor. The obtained mesoporous carbon has platelet morphology, short mesoporous channel together with a large surface area (549 m(2)/g) as well as rich N- and S-containing functional groups (6.8 at.% N and 2.3 at.% S). Compared with the graphene (GR) and carbon nanotube (CNT) electrode material, the N,S-OMC exhibited a higher electrochemical activity towards the oxidation of herbicide amitrole, ascribable to N,S-OMC’s open mesoporous structures and abundant electroactive defect sites on the carbon skeleton. And, an amitrole electrochemical sensor with N,S-OMC modified electrode as working electrode was fabricated, exhibiting a good selectivity, stability, reproducibility and wide linear range of 3-750 mu M. Moreover, the N,S-OMC-based electrochemical sensor was proved feasible in river water sample analyses, showing a satisfied recovery ranging from 97.03% to 105.42%. The results not only demonstrate cheap methylene blue can be used as single precursor for the N,S-OMC preparation, but also confirm the N,S-OMC is promising in amitrole sensor fabrication.

SDS of cas: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Wei, YJ; Gao, J; Feng, Y; Wang, N; Gao, JF or send Email.

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Formula: C2H4N4. Recently I am researching about GANCICLOVIR; INHIBITION; MUTATIONS, Saw an article supported by the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201100016I]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC50:<0.05M) against a normal laboratory HCMV strain (AD-169) in human foreskin fibroblast cells than Ganciclovir (EC50=0.32M), an anti-HCMV agent in clinical use. Additionally, the HCMV-resistant isolate (GDGr K-17) was tested for sensitivity to 1,3-oxazole derivatives with most antiviral potency against the strain AD169. A one of them (5-((2-hydroxyethyl)(methyl)amino)-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile) showed very high potency (EC50:<0.05; CC50: >150 mu M, and SI50=3125) towards the resistant isolate compared to standard drugs Cidofovir (EC50=0.10 mu M, CC50: >30 mu M and SI50: <4). But, in contrast to the primary assays, the antiviral activity of these compounds against both the normal strain and the resistant isolate of HCMV were considerably less than one of Cidofovir in secondary assay. These results provided evidence that derivatives of 1,3-oxazole could be useful for developing new anti-HCMV drugs. Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

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Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

In 2019.0 J SOLID STATE ELECTR published article about REDUCED GRAPHENE OXIDE; GOLD NANOPARTICLES; NANOCOMPOSITES; OXIDATION; BEHAVIOR; TETRAAMINOPHTHALOCYANINE; NANOSHEETS; REDUCTION; NANOTUBES; OXYGEN in [Mafuwe, Peter T.; Moyo, Mambo; Mugadza, Tawanda; Shumba, Munyaradzi] Midlands State Univ, Dept Chem Technol, Sensors Lab, P Bag 9055,Senga Rd, Gweru, Zimbabwe; [Nyoni, Steven] Chinhoyi Univ Technol, Dept Chem, Chinhoyi, Zimbabwe in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Cobalt oxide nanoparticles were anchored on polyaniline-appended cobalt phthalocyanine and used to modify glassy carbon electrodes for enhanced electrocatalytic oxidation of amitrole. The modified electrodes were characterised by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. Cyclic voltammetry, linear sweep voltammetry, chronoamperometry and differential pulse voltammetry were used to evaluate the electrocatalytic behaviour of the designed sensors. Catalytic rate constant of 6.26×10(5)M(-1)s(-1) and apparent electron transfer rate constant of 8.84×10(-3)cms(-1) were observed on CoTCPc-PANI-Co3O4NP-GCE. The adsorption equilibrium constant and Gibbs energy were 4.8×10(1)M(-1) and -12.1kJmol(-1), respectively, confirming substrate adsorption during a spontaneous reaction on the surface of the modified electrode. The limit of detection and limit of quantification were 6.61×10(-8)M and 2×10(-7)M, respectively, for the electrocatalytic detection of amitrole and only suffered 4% signal loss after repetitive ten runs in 1mM amitrole.

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Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Quality Control of 1H-1,2,4-Triazol-5-amine. Authors Cen, HY; Chen, ZY in ELSEVIER published article about in [Cen, Hongyu; Chen, Zhenyu] Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China in 2021.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Functionalized graphene oxide (FGO) were synthesized and investigated as corrosion inhibitors of carbon steel in this research. The inhibition behavior of FGO in CO2-saturated NaCl solution was studied via weight loss, surface characterizations, and electrochemical measurements. Results confirm that FGO could protect metal effectively and the inhibition efficiency showed the extreme effect as the increase of FGO concentration, reaching a maximum of 83.4% at 20 mg/L. FGO can adsorb on carbon steel via the functionalized groups and form the hydrophobic cover layer on the metal surface by the lamellar nanoparticles.

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Product Details of 61-82-5. In 2020.0 XENOBIOTICA published article about THYROPEROXIDASE INHIBITION; MECHANISM in [Price, Roger J.; Lake, Brian G.] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England; [Burch, Rachel] Brunel Univ, Res Support & Dev Off, Uxbridge, Middx, England; [Chatham, Lynsey R.; Higgins, Larry G.] CXR Biosci Ltd, Concept Life Sci, Dundee, Scotland; [Currie, Richard A.] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell, Berks, England in 2020.0, Cited 16.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

1. A number of chemicals have been shown to produce disruption of the thyroid gland, resulting in reduced thyroid hormone synthesis, by a mechanism involving inhibition of thyroid peroxidase (TPO) activity (EC 1.11.1.8). 2. An assay was developed for rat thyroid gland microsomal TPO activity, employing L-tyrosine as the physiological substrate, with analysis of the formation of the 3-iodo-L-tyrosine (3MIT) metabolite by ultra-performance liquid chromatography-mass spectrometry-mass spectrometry. 3. Formation of 3MIT was linear with respect to both rat thyroid gland microsomal protein concentration and incubation time, whereas only small quantities of 3,5-diodo-L-tyrosine were formed. 4. Studies were performed with nine known TPO inhibitors. The most potent inhibitors were 3-amino-1,2,4-triazole, ethylene thiourea, methimazole and 6-propyl-2-thiouracil which had IC50 values (i.e. concentration to produce a 50% inhibition of enzyme activity) of 0.059, 0.791, 1.07 and 1.96 mu M, respectively, whereas the least potent inhibitor was sodium perchlorate which had an IC50 value of 13,800 mu M. 5. For five inhibitors, where literature data were available, the observed IC50 values obtained in this study employing rat thyroid gland microsomes and L-tyrosine as substrate were similar to those previously reported using the spectrophotometric guaiacol oxidation assay.

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In 2019.0 NANO published article about EFFICIENT CARBOCATALYST; NANOPARTICLES; GRAPHENE; ACID; NANOSPHERES; PERFORMANCE; ELECTRODES; OXIDATION in [Zhou, Shenghai; Xu, Hongbo; Wei, Yanjun; Gao, Jing; Feng, Yue; Gao, Junfeng] Hebei Normal Univ Nationalities, Dept Chem & Chem Engn, Chengde 067000, Peoples R China; [Wang, Ning] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China in 2019.0, Cited 43.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

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Authors El Sayed, MT; Sarhan, AE; Ahmed, E; Khattab, RR; Elnaggar, M; El-Messery, SM; Shaldam, MA; Hassan, GS in WILEY-V C H VERLAG GMBH published article about TRANSITION-METAL COMPOUNDS; DENSITY-FUNCTIONAL THEORY; MOLECULAR-STRUCTURES; DOCKING; MOLYBDENUM; INDOLES; MANNICH; BONDS in [El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Dokki 12311, Egypt; [Sarhan, Alaadin E.] Natl Res Ctr, Pharmaceut Div, Therapeut Chem Dept, Dokki 12311, Egypt; [Ahmed, Entsar] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, Cairo, Egypt; [Khattab, Reham R.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Dokki 12311, Egypt; [Elnaggar, Mohamed] Univ Sharjah, Fac Sci, Chem Dept, Sharjah 27272, U Arab Emirates; [El-Messery, Shahenda M.] Mansoura Univ, Fac Pharm, Dept Organ Pharmaceut Chem, POB 35516, Mansoura, Egypt; [Shaldam, Moataz A.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, Kafr Al Sheikh 33516, Egypt; [Hassan, Ghada S.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt in 2020.0, Cited 39.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In the present investigation, some novel nitro Mannich bases derived from Michael type addition of activated nitro olefin, beta-nitrostyrene with various amines either primary or secondary including some amino sugars were designed and synthesized. The produced Mannich bases have been full characterized through different spectroscopic techniques. Antimicrobial evaluation has been performed against the Gram positive S. aureus and methicillin-resistant S. aurues (MRSA) infections. 5 of the synthesized compounds represent the best candidates in the biological screening, they have exhibited good activity with MIC values range from 100 to 250 mu g/ml. The active agents have been tested for pyruvate kinase inhibition activity with % of inhibition range from 30 to 79 % with IC50 in a nano molar range. They also exhibited significant Pyruvate kinase inhibition in nanomolar range with IC50 of 1066, 662, 1887, 418 and 1128 ng/ml, respectively (versus 196 ng/ml for AZD7545). Molecular docking calculations for active agents were performed. A complete conformational analysis molecular modeling utilizing Gaussian 09 program (HF/DFT) was used to verify the mode of bonding through the optimized geometries as well as essential quantum parameters were calculated using frontier energies (EHOMO & ELUMO) for the active candidates indicating the overall stability of the structure.

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