Tag: M.W=0-100

In 2020.0 ENVIRON SCI TECHNOL published article about THROUGHPUT SCREENING ASSAYS; DRUG DISCOVERY; BINDING AFFINITIES; TOXCAST CHEMICALS; QSAR; IDENTIFICATION; CLASSIFICATION; AGREEMENT; SET in [Zorn, Kimberley M.; Foil, Daniel H.; Lane, Thomas R.; Ekins, Sean] Collaborat Pharmaceut Inc, Raleigh, NC 27606 USA; [Russo, Daniel P.] Rutgers State Univ, Ctr Computat & Integrat Biol, Camden, NJ 08102 USA; [Hillwalker, Wendy; Feifarek, David J.; Jones, Frank; Klaren, William D.; Brinkman, Ashley M.] SC Johnson & Son Inc, Global Prod Safety, Racine, WI 53404 USA in 2020.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

The U.S. Environmental Protection Agency (EPA) periodically releases in vitro data across a variety of targets, including the estrogen receptor (ER). In 2015, the EPA used these data to construct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrine disruption testing. However, mathematical models require in vitro data prior to predicting estrogenic activity, but machine learning methods are capable of prospective prediction from the molecular structure alone. The current study describes the generation and evaluation of Bayesian machine learning models grouped by the EPA’s ER agonist pathway model using multiple data types with proprietary software, Assay Central. External predictions with three test sets of in vitro and in vivo reference chemicals with agonist activity classifications were compared to previous mathematical model publications. Training data sets were subjected to additional machine learning algorithms and compared with rank normalized scores of internal five-fold cross-validation statistics. External predictions were found to be comparable or superior to previous studies published by the EPA. When assessing six additional algorithms for the training data sets, Assay Central performed similarly at a reduced computational cost. This study demonstrates that machine learning can prioritize chemicals for future in vitro and in vivo testing of ER agonism.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019.0 PLANT CELL PHYSIOL published article about ABSCISIC-ACID; SEED-GERMINATION; CELL-DIVISION; GENE-EXPRESSION; POTATO-TUBERS; CLASS-I; ARABIDOPSIS; CYTOKININ; GROWTH; BIOSYNTHESIS in [Wu, Jian; Wu, Wenjing; Liang, Jiahui; Jin, Yujie; He, Junna; Yi, Mingfang] China Agr Univ, Dept Ornamental Hort & Landscape Architecture, Beijing Key Lab Dev & Qual Control Ornamental Cro, Beijing 100193, Peoples R China; [Wu, Jian; Gazzarrini, Sonia] Univ Toronto Scarborough, Dept Biol Sci, Toronto, ON, Canada; [Gazzarrini, Sonia] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada in 2019.0, Cited 55.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

Dormancy is one of the least understood phenomena in plant biology; however, bud/corm dormancy is an important economic trait in agricultural/horticultural breeding. In this study, we isolated an ABA biosynthesis gene, GhNCED, from the transcriptome database of corm dormancy release (CDR), and characterized its negative role in regulating CDR. To understand transcriptional regulation of GhNCED, yeast one-hybrid screening was conducted and GhTCP19 was identified and shown to regulate GhNCED expression directly. An in planta assay showed that GhTCP19 negatively regulates GhNCED expression. GhTCP19 is dramatically induced by exogenous cytokinins (CKs) and is induced during CDR. Silencing of GhTCP19 in dormant cormels delayed CDR, resulting in higher expression of GhNCED and ABA levels. Meanwhile, endogenous CK biosynthesis and signaling were inhibited in GhTCP19-silenced cormels. Taken together, our results reveal that GhTCP19 is a positive regulator of the CDR process by repressing expression of an ABA biosynthesis gene (GhNCED), promoting CK biosynthesis (GhIPT) and signal transduction (GhARR) as well as inducing cyclin genes. This study expands our knowledge on CDR which is mediated by TCP family members.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Wu, J; Wu, WJ; Liang, JH; Jin, YJ; Gazzarrini, S; He, JN; Yi, MF or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ONE-POT SYNTHESIS; EFFICIENT CATALYST; SULFURIC-ACID; SOLID ACID; 3-COMPONENT; GREEN; BENZIMIDAZOQUINAZOLINONE; PHTHALAZINE; SULFATE; SYSTEMS, Saw an article supported by the University of Guilan Research Council. Category: Triazoles. Published in ELSEVIER in AMSTERDAM ,Authors: Safari, N; Shirini, F; Tajik, H. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C-4(H-DABCO)(2)][HSO4](4) is easily prepared and characterized using FT-IR, H-1 NMR,C-13 NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method. (C) 2019 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Chamber Protection of Copper from Atmospheric Corrosion by Compounds of the Triazole Class WOS:000603324200008 published article about SATURATED VAPOR-PRESSURE; BENZOTRIAZOLE; INHIBITION; IMPEDANCE; DERIVATIVES; PREDICTION; ADSORPTION; BEHAVIOR; KINETICS; FILMS in [Goncharova, O. A.; Luchkin, A. Yu; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 46.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (electrochemical impedance spectroscopy and polarization measurements), and corrosion (periodic moisture condensation and salt fog tests) methods, the properties of adsorption films formed on copper by the chamber method from vapors of benzotriazol (BTA), 1H-1,2,4-triazole, tolyltriazole (TTA), 5-chloro-1,2,3-benzotriazole (CBTA), 3-amino-1H-1,2,4-triazole, and 4-amino-1H-1,2,4-triazole at a temperature of 100 degrees C are studied. It is shown that 1-h chamber treatment of copper with vapors of these compounds leads to the formation of nanoscale hydrophobic adsorption films on it, which inhibits the thermal growth of oxides, but stabilizes the passive state of the metal and increases its corrosion resistance. Among these different triazole compounds tested as chamber corrosion inhibitors, BTA and its substituted derivatives are distinguished. After a 1-h chamber treatment of copper, the protective aftereffect of the adsorption films of triazole derivatives grows symbatically with their saturated vapor pressure at the chamber treatment temperature, i.e., in the following increasing order: CBTA < TTA < BTA. This may indicate that the equilibrium adsorption films do not have time to form at 100 degrees C on the metal within this time period. After a prolonged (24 h or more) chamber treatment of copper with vapors of substituted benzotriazoles, equilibrium adsorption films of inhibitors are formed on it. In this case, the influence of the chamber inhibitor properties on their protective aftereffect alternates. Under such conditions, the least volatile and most hydrophobic substituted benzotriazole, i.e., CBTA, provide the best metal protection. Welcome to talk about 61-82-5, If you have any questions, you can contact Goncharova, OA; Luchkin, AY; Andreev, NN; Kuznetsov, YI; Andreeva, NP or send Email.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Mabkhot, YN; Kaal, NA; Alterary, S; Mubarak, MS; Alsayari, A; Bin Muhsinah, A in [Mabkhot, Yahia Nasser] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia; [Kaal, Nahed Ahmed; Alterary, Seham] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Mubarak, Mohammad S.] Univ Jordan, Dept Chem, Amman 11942, Jordan; [Alsayari, Abdulrhman; Bin Muhsinah, Abdullatif] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha, Saudi Arabia published New Thiophene Derivatives as Antimicrobial Agents in 2019.0, Cited 25.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5-(2-bromo-acetyl)-substituted-thiophene derivative has been used as a synthon for synthesis of new thiophene-containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.

Welcome to talk about 61-82-5, If you have any questions, you can contact Mabkhot, YN; Kaal, NA; Alterary, S; Mubarak, MS; Alsayari, A; Bin Muhsinah, A or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about CHEMICAL FIXATION; CO2; PERFORMANCE; SEPARATION; POLYMER; MOF; MG, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51672186, 21908090]; Natural Science Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi Province [20192ACB21015]; Nanchang University; Arizona State University. Safety of 1H-1,2,4-Triazol-5-amine. Published in SPRINGER in NEW YORK ,Authors: Luo, ZQ; Wang, J; He, YQ; Ao, Q; Deng, Q; Zeng, ZL; Wang, HM; Deng, SG. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Developing highly efficient heterogeneous catalysts for cycloaddition of CO2 and epoxides to produce cyclic carbonates is promising but challenging. In this work, a novel three-dimensional metal organic framework (MOF) with cylinder pore systems and unsaturated Zn sites has been demonstrated as potent candidate in CO2 fixation at mild and solvent-free conditions. The Zn(atz)(bdc)(0.5), where atz = aminotriazole and H(2)bdc = terephthalic, exhibits microporous nature that can regulate the catalytic interaction of active centers and substrates. The structure stability has been systematically investigated and proven to be sufficient for practical application. Furthermore, the cooperative effects of porosity, CO2 binding affinity, activation centers, and synergism with co-catalyst have been deeply investigated. Moreover, high propylene epoxide conversion (97%) and selectivity (> 99%) have been achieved at mild conditions (60 degrees C and 1 MPa) with excellent cycle stability. Owing to the well-defined pore system, an obvious substrates selectivity has been clearly observed. A possible catalytic mechanism has been proposed and verified by DFT calculations. Furthermore, the prepared Zn-MOF can also be used as an efficient heterogeneous catalyst for the reaction of epoxides with alcohols to produce beta-alkoxy alcohol. [GRAPHICS] .

Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Divalent manganese, cobalt, copper and cadmium complexes of (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid: Preparation, characterization, computational and biological studies WOS:000578430900001 published article about METAL-COMPLEXES; CU(II) COMPLEXES; ANTIOXIDANT; NI(II); CO(II); HYDRAZIDE; SPECTRA; CD(II); MODELS; ZN(II) in [Majeed, Abdulnasir A.; Khalil, Mostafa M. H.; Abdel Aziz, Ayman A.] Ain Shams Univ, Dept Chem, Fac Sci, Cairo, Egypt; [Fetoh, Ahmed; Abu El-Reash, G. M.] Mansoura Univ, Dept Chem, Fac Sci, POB 70, Mansoura, Egypt in 2021.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

In this work, (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H-1,2,4-triazol-3-amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E-a, A, Delta H*, Delta S* and Delta G*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS-antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF-7 (breast carcinoma) cancer cells.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about THIENOPYRIDINONE ANTIBACTERIALS; BIOLOGICAL EVALUATION; PART; DERIVATIVES; ACIDS, Saw an article supported by the Deanship of Scientific Research at the University of Jordan, Amman-Jordan. COA of Formula: C2H4N4. Published in WALTER DE GRUYTER GMBH in BERLIN ,Authors: Sweidan, NI; El-Abadelah, MM; Nazer, MZ; Voelter, W. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Interaction of methyl 3-ethoxy-2-(2,5-dichloro-3-thenoyl)acrylate (I) with 3-aminopyrazole and 3- amino-1,2,4-triazole generated the respective pyrazolo [1,5-alpha]pyrimidine (4) and triazolo[1,5-alpha]pyrimidine (7). The formation of 4 entails selective and consecutive displacement of the 3-ethoxy and methoxy (ester) anions in I by 3-NH2 and 1-NH of 3-aminopyrazole. On the other hand, the formation of 7 implies selective displacement of 3-ethoxy in I by the ring-NH followed by cyclocondensation involving the keto group in I and 3-NH2 of aminotriazole. This latter selective displacement sequence is also followed by 3-amino-5-hydroxypyrazole in its reaction with I. The structures of the new compounds are supported by microanalytical and spectral data.

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Sweidan, NI; El-Abadelah, MM; Nazer, MZ; Voelter, W or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design and synthesis of new indole containing biaryl derivatives as potent antiproliferative agents published in 2021.0. Safety of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Yu, B; Liu, HM (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China.; Yu, B; Liu, HM (corresponding author), Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China.; Xie, ZY (corresponding author), Xuchang Univ, Coll Chem & Mat Engn, 88 Bayi Rd, Xuchang 461000, Henan, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

A new series of indole containing biaryl derivatives were designed and synthesized, and further biological evaluations of their antiproliferative activity against cancer cell lines (MGC-803 and TE-1 cells) were also conducted. Of these synthesized biaryls, compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl) methyl)quinazoline (23) performed as the most potent antiproliferative agent that inhibited cell viability of MGC-803 cells with an IC50 value of 8.28 mu M. In addition, investigation of mechanism exhibited that the compound 4-methyl-2-((5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)methyl)quinazoline (23) could inhibit the expression of c-Myc and glycolysis related proteins, decrease the ATP and lactate production, and further induce apoptosis by activating the AMP-activated protein kinase (AMPK) and p53 signaling pathways.

Welcome to talk about 61-82-5, If you have any questions, you can contact Yuan, S; Feng, SQ; Li, AQ; Zuo, JH; Zhang, DQ; Xing, YJ; Xie, ZY; Yu, B; Liu, HM or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. In 2019.0 PLANT CELL PHYSIOL published article about ABSCISIC-ACID; SEED-GERMINATION; CELL-DIVISION; GENE-EXPRESSION; POTATO-TUBERS; CLASS-I; ARABIDOPSIS; CYTOKININ; GROWTH; BIOSYNTHESIS in [Wu, Jian; Wu, Wenjing; Liang, Jiahui; Jin, Yujie; He, Junna; Yi, Mingfang] China Agr Univ, Dept Ornamental Hort & Landscape Architecture, Beijing Key Lab Dev & Qual Control Ornamental Cro, Beijing 100193, Peoples R China; [Wu, Jian; Gazzarrini, Sonia] Univ Toronto Scarborough, Dept Biol Sci, Toronto, ON, Canada; [Gazzarrini, Sonia] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada in 2019.0, Cited 55.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Dormancy is one of the least understood phenomena in plant biology; however, bud/corm dormancy is an important economic trait in agricultural/horticultural breeding. In this study, we isolated an ABA biosynthesis gene, GhNCED, from the transcriptome database of corm dormancy release (CDR), and characterized its negative role in regulating CDR. To understand transcriptional regulation of GhNCED, yeast one-hybrid screening was conducted and GhTCP19 was identified and shown to regulate GhNCED expression directly. An in planta assay showed that GhTCP19 negatively regulates GhNCED expression. GhTCP19 is dramatically induced by exogenous cytokinins (CKs) and is induced during CDR. Silencing of GhTCP19 in dormant cormels delayed CDR, resulting in higher expression of GhNCED and ABA levels. Meanwhile, endogenous CK biosynthesis and signaling were inhibited in GhTCP19-silenced cormels. Taken together, our results reveal that GhTCP19 is a positive regulator of the CDR process by repressing expression of an ABA biosynthesis gene (GhNCED), promoting CK biosynthesis (GhIPT) and signal transduction (GhARR) as well as inducing cyclin genes. This study expands our knowledge on CDR which is mediated by TCP family members.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics