Tag: M.W=0-100

An article Effect of Fe3O4-Decorated N-Doped Reduced Graphene Oxide Nanohybrid on the Anticorrosion Performance of Epoxy Composite Coating WOS:000514099500005 published article about FUNCTIONALIZED GRAPHENE; CORROSION PROTECTION; GRAPHITE OXIDE; ENHANCEMENT; RESISTANCE; NANOSHEETS; INHIBITORS; ZIRCONIA; DELIVERY; CATALYST in [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] CSIR Cent Mech Enging Res Inst, Surface Engn & Tribol Div, Durgapur 713209, India; [Chhetri, Suman; Ghosh, Souvik; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2019.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The present study explores the synergistic effect of Fe3O4 and heteroatom doped reduced graphene oxide (rGO) nanohybrid on anti-corrosion performance of epoxy composite coating. In this connection, Fe3O4 nanoparticles were decorated over nitrogen doped rGO (Fe3O4-NRG) and characterized by Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD), X-ray Photoelectron spectroscopy (XPS), and Thermogravimetric analysis (TGA). This approach to modulating the surface properties of graphene and hence the interaction with polymer matrix were quite distinct from traditional surface functionlization or decoration in a sense that the doped nitrogen atom facilitate the growth of Fe3O4 particles and at the same time augmented the interaction of rGO with polymer matrix. The prepared nanohybrid was dispersed in epoxy matrix through mechanical mixing and coated over mild steel surface via spin coating technique. The potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) study revealed superior anti-corrosion performance of Fe3O4-NRG/epoxy coating in 3.5 wt% NaCl solution. The corrosion inhibition was found to improve by similar to 98.5% with 0.5 wt% loading of Fe3O4-NRG. We believe that this simple solvent free approach to prepare composite coating can be exploit for practical application and thus deserves special attention..

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Sompalle, R; Roopan, SM; Priya, DD; Suthindhiran, K; Sarkar, G; Ranjith, M; Arunachalapandi, M in WILEY-V C H VERLAG GMBH published article about CARBOXYLIC-ACID DERIVATIVES; ANTITUMOR AGENTS; ANTIOXIDANT; INHIBITORS; DESIGN; POTENT in [Sompalle, Rajesh; Roopan, Selvaraj Mohana; Priya, Duraipandi Devi; Arunachalapandi, Murugan] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Chem Heterocycles & Nat Prod Res Lab, Vellore 632014, Tamil Nadu, India; [Sompalle, Rajesh] Besant Theosoph Coll, Dept Chem, Chittoor 517325, Andhra Pradesh, India; [Suthindhiran, Krishnamurthy; Sarkar, Gargi] Vellore Inst Technol, Sch Biosci & Technol, Marine Biotechnol & Bioprod Lab, Vellore 632014, Tamil Nadu, India; [Ranjith, Malavika] Vellore Inst Technol, Sch Chem Engn, Vellore 632014, Tamil Nadu, India in 2020.0, Cited 45.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Microwave synthetic methodologies were proposed for the preparation of positional isomeric dihydro-triazolo-pyrimido-acridines, 3a-j and 9a-h via friedlander synthesis using response surface methodology (RSM). The advantages of these methodologies over conventional methods are it provides good yields with short reaction times. Free radical scavenging and antifungal studies were performed for compounds 3a-j and 9a-h. The results of antioxidant assay revealed that compounds 3c, 3d and 9b exhibited excellent property whereas compounds 3a and 9a showed significant antifungal property against Aspergillus flavus (A.flavus) and Aspergillus niger (A. niger).

Welcome to talk about 61-82-5, If you have any questions, you can contact Sompalle, R; Roopan, SM; Priya, DD; Suthindhiran, K; Sarkar, G; Ranjith, M; Arunachalapandi, M or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about METAL-ORGANIC FRAMEWORK; EFFICIENT; ACID; 5-AMINO-TETRAZOLATE; ANTIBIOTICS; SEPARATION; COMPLEXES; SERIES; MOFS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21543001]; Education Committee of Shaanxi Province [17J5131]; Top-rated Discipline construction scheme of Shaanxi higher education. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Zhang, SY; Liu, B; Zhang, SH; Yue, KF; Huang, ZQ. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Product Details of 61-82-5

Solvothermal reactions of Zn(NO3)(2)center dot 6H(2)O, 3-amino-1,2,4-triazole as well as three different carboxylate ligands afforded three novel coordination polymers: [Zn-2 (azdc) (atz) (OH) (H2O)](n) (1), {[Zn-1.5 (btc)(0.5) (atz)]center dot 1.5H(2)O}(n) (2), and {[Zn-4 (nipa)(2) (atz)(3)(OH) (H2O)]center dot 2H(2)O}(n) (3) (H(2)azdc = 4,4′-azobenzoic acid, H(4)btc = 1,2,4,5-benzenetetracarboxylic acid, 5-H(2)nipa = 5-nitroisophthalic acid, Hatz = 3-amino-1,2,4-triazole). Moreover, the three coordination polymers have been characterized by IR spectroscopy, elemental analysis, single-crystal X-ray diffraction, and powder X-ray diffraction techniques. Complex 1 reveals a 2D layer structure, which is further connected through pi-pi stacking interactions forming a 3D supramolecular network. Complex 2 exhibits a 3D porous framework with 1D open channels. Complex 3 shows a 3D pillared-layer framework. Notably, the thermal decomposition processes of 1-3 were investigated by simultaneous TG-DSC techniques. The TG curves reveal that complexes 1-3 possess pretty good thermostability up to 321 degrees C, 416 degrees C and 418 degrees C, respectively. The apparent activation energy E (E-1 = 194.975 kJ mol(-1), E-2 = 220.360 kJ mol(-1), E-3 = 223.600 kJ mol(-1)) and the pre exponential factor A of skeleton collapse for the complexes 1-3 were calculated by the integral Kissinger’s method and Ozawa-Doyle’s method. The structural stability could be illustrated from the point of thermal decomposition kinetics.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, SY; Liu, B; Zhang, SH; Yue, KF; Huang, ZQ or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis of C-beta-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase WOS:000455623300004 published article about GLUCOSE ANALOG INHIBITORS; BINDING; NUCLEOSIDES; IMIDAZOLES; REVEAL; MUSCLE in [Szennyes, Eszter; Bokor, Eva; Somsak, Laszlo] Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary; [Docsa, Tibor; Sipos, Adam] Univ Debrecen, Fac Med, Dept Med Chem, Egyet Ter 1, H-4032 Debrecen, Hungary in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

Annulated C-beta-D-glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase. 2-(beta-D-Glucopyranosyl)-1H-imidazo[4,5-b] pyridine was formed by ring-closure of O-perbenzoylated C-beta-D-glucopyranosyl formic acid with 2,3-diaminopyridine in the presence of triphenylphosphite. Cyclisations of bromomethyl 2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl ketone with a set of 2-aminoheterocycles resulted in constitutionally reversed C-beta-D-glucopyranosyl imidazoles fused by pyridine, pyrimidine, thiazole, 1,3,4-thiadiazole, benzothiazole and benzimidazole. O-Debenzoylation of the above compounds was effected by standard transesterification to get the test compounds. The 1H-imidazo[4,5-b] pyridine proved to be a low micromolar inhibitor (K-i = 21.1 mu M) of rabbit muscle glycogen phosphorylase b, while the other heterocycles displayed weak or no inhibition against the same enzyme.

Welcome to talk about 61-82-5, If you have any questions, you can contact Szennyes, E; Bokor, E; Docsa, T; Sipos, A; Somsak, L or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 APPL CATAL B-ENVIRON published article about GRAPHITIC CARBON NITRIDE; DOPED G-C3N4 NANOSHEETS; TEMPLATE-FREE SYNTHESIS; HIGHLY EFFICIENT; ORGANIC PHOTOCATALYST; HYDROGEN-PRODUCTION; NANOTUBE ARRAYS; H-2 EVOLUTION; QUANTUM DOTS; LIGHT in [Gao, Qiuzhu; Xu, Jing; Wang, Zhouping] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China; [Gao, Qiuzhu; Xu, Jing; Wang, Zhouping] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China; [Gao, Qiuzhu; Xu, Jing; Wang, Zhouping] Jiangnan Univ, Int Joint Lab Food Safety, Wuxi 214122, Jiangsu, Peoples R China; [Gao, Qiuzhu; Xu, Jing; Wang, Zhouping] Jiangnan Univ, Collaborat Innovat Ctr Food Safety & Qual Control, Wuxi 214122, Jiangsu, Peoples R China; [Zhu, Yongfa] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China in 2020.0, Cited 47.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Herein, perylene diimide (PDI)/oxygen-doped g-C3N4 nanosheets (O-CN) n-n heterojunction photocatalyst was prepared by an in-situ electrostatic assembling. The pi-pi interaction between self-assembled PDI and O-CN could lead to the electron delocalization effect to facilitate the electron migration. Self-assembled PDI could broaden the visible response range of O-CN to produce more photogenerated carries. Moreover, the interlaced band structures of O-CN and self-assembled PDI could result in a built-in electric field to promote the interfacial charge separation. Besides, many active species (h(+), O-center dot(2-) and O-1(2) ) could be accumulated to improve the oxidation ability of PDI/O-CN. Therefore, PDI/O-CN exhibited enhanced visible photocatalytic oxidation activities towards disinfection, degradation and oxygen evolution. The optimum PDI/O-CN inactivated 96.6% of Staphylococcus aureus cells within 3 h, while O-CN only killed 62.2%. Additionally, the phenol degradation rate and evolved oxygen amount in 2 h of PDI/O-CN-40% were 3.6 and 1.8 times as high as those of O-CN, respectively.

Welcome to talk about 61-82-5, If you have any questions, you can contact Gao, QZ; Xu, J; Wang, ZP; Zhu, YF or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Science & Technology – Other Topics very interesting. Saw the article NoPv1: a synthetic antimicrobial peptide aptamer targeting the causal agents of grapevine downy mildew and potato late blight published in 2020.0. Formula: C2H4N4, Reprint Addresses Vezzulli, S (corresponding author), Fdn Edmund Mach, Res & Innovat Ctr, San Michele All Adige, Italy.; Pesaresi, P (corresponding author), Univ Milan, Dept Biosci, Milan, Italy.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Grapevine (Vitis vinifera L.) is a crop of major economic importance. However, grapevine yield is guaranteed by the massive use of pesticides to counteract pathogen infections. Under temperate-humid climate conditions, downy mildew is a primary threat for viticulture. Downy mildew is caused by the biotrophic oomycete Plasmopara viticola Berl. & de Toni, which can attack grapevine green tissues. In lack of treatments and with favourable weather conditions, downy mildew can devastate up to 75% of grape cultivation in one season and weaken newly born shoots, causing serious economic losses. Nevertheless, the repeated and massive use of some fungicides can lead to environmental pollution, negative impact on non-targeted organisms, development of resistance, residual toxicity and can foster human health concerns. In this manuscript, we provide an innovative approach to obtain specific pathogen protection for plants. By using the yeast two-hybrid approach and the P. viticola cellulose synthase 2 (PvCesA2), as target enzyme, we screened a combinatorial 8 amino acid peptide library with the aim to identify interacting peptides, potentially able to inhibit PvCesa2. Here, we demonstrate that the NoPv1 peptide aptamer prevents P. viticola germ tube formation and grapevine leaf infection without affecting the growth of non-target organisms and without being toxic for human cells. Furthermore, NoPv1 is also able to counteract Phytophthora infestans growth, the causal agent of late blight in potato and tomato, possibly as a consequence of the high amino acid sequence similarity between P. viticola and P. infestans cellulose synthase enzymes.

Welcome to talk about 61-82-5, If you have any questions, you can contact Colombo, M; Masiero, S; Rosa, S; Caporali, E; Toffolatti, SL; Mizzotti, C; Tadini, L; Rossi, F; Pellegrino, S; Musetti, R; Velasco, R; Perazzolli, M; Vezzulli, S; Pesaresi, P or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Fire behavior of flame retarded unsaturated polyester resin with high nitrogen content additives WOS:000525305000004 published article about GLASS-TRANSITION TEMPERATURE; CROSS-LINK DENSITY; AMMONIUM POLYPHOSPHATE; MECHANICAL-PROPERTIES; THERMAL-STABILITY; CHAR FORMATION; COMPOSITES; COMBUSTION; PHOSPHORUS; PHOSPHATE) in [Salasinska, Kamila; Celinski, Maciej; Borucka, Monika; Kozikowski, Pawel] Cent Inst Labour Protect, Dept Chem Biol & Aerosol Hazards, Natl Res Inst, Czerniakowska 16, PL-00701 Warsaw, Poland; [Barczewski, Mateusz] Poznan Univ Tech, Piotrowo 3, PL-61138 Poznan, Poland; [Leszczynski, Michal K.] Polish Acad Sci, Inst Phys Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland in 2020.0, Cited 56.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

The novel flame retarded unsaturated polyester resins have been developed and prepared by introduction of high nitrogen content additives into the polymer matrix in order to verify their effectiveness in the formation of swollen carbonaceous char inhibiting the burning process of the polymer. The intumescent flame retardants (IFRs) based on mixture or metal complex were developed and characterized by particle size distribution, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), powder X-ray diffraction (XRD), elemental analysis (CHN) and thermogravimetric analysis (TGA). The evaluation of the efficiency of IFRs addition on the flammability and smoke emission of the unsaturated polyester resins (UP) was carried out using the fire hazard (UL-94), limiting oxygen index (LOI) and cone calorimeter (CC) tests, as well as smoke density chamber tests. The volatile compounds evolved during the burning of materials were determined using a steady state tube furnace and a gas chromatograph with mass spectrometer. Furthermore, the prepared materials were subjected to differential scanning calorimetry (DSC), thermogravimetric analysis and water resistance tests. The mechanical properties of the materials were investigated using Shore D hardness and dynamic mechanical thermal analysis (DMA). The structural evaluation of the manufactured materials and samples after the cone calorimetry tests was carried out using scanning electron microscopy (SEM). It was found that the incorporation of new intumescent flame retardants led to the formation of carbonaceous char layers’ inhibiting the decomposition process and limiting the smoke emission. The most promising results were obtained for the resin containing complex designated as ZN3AT, for which the highest reduction in maximum values of heat release rate (419 kW/m(2)) compared to unmodified polymer (792 kW/m(2)) were recorded. Apart from that, the prepared intumescent flame retardants affect the cross-linking process as well as the thermal and mechanical properties of the UP.

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Salasinska, K; Celinski, M; Barczewski, M; Leszczynski, MK; Borucka, M; Kozikowski, P or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT in ELSEVIER SCIENCE BV published article about IONIC LIQUIDS; ENANTIOMERIC SEPARATION; BETA-CYCLODEXTRINS; ENANTIOSEPARATION; PERFORMANCE; COMPLEXES; MECHANISM; LIGAND; DRUGS; MODEL in [Liu, Jie; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Ma, Xiaofei; Li, Jingtang] China Pharmaceut Univ, Dept Analyt Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 39.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated. Molecular modeling was applied to demonstrate the chiral recognition mechanism of the LA-ATM, which well supported the experimental results. Furthermore, a mathematical equation built up based on the molecular mechanics calculations was used in predicting resolution of tested drugs using LA or LA-ATM mediated CE, the predicted result was well correlated with the experimental result. (C) 2019 Published by Elsevier B.V.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ACID-DERIVATIVES; TRIAZOLE, Saw an article supported by the Imam Khomeini International University, Iran. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Safari, F; Bayat, M; Nasri, S; Karami, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. HPLC of Formula: C2H4N4

Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products with potential anti-tumor activities. In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and Nmethyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Bronsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo [1,5-a] pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of our synthetic compounds on different cancer cells including human malignant melanoma cells (A375), prostate cancer cells (PC3 cells, LNCaP cells) and normal cells HDF (human dermal fibroblast). Notably, we found that compound 4b that contains a nitro group has the best antitumor activity on three different cancer cells. By using DAPI staining, we showed cancer cells death. Apoptosis induction was shown using quantitative real time PCR (qRT-PCR) by evaluating of Bax and Bcl2 mRNA levels. Finally, we demonstrated that 4b has epithelial-to-mesenchymal transition (EMT) inhibition effect on cancer cells (by induction of E-cadherin and reduction of vimentin mRNA expression levels as two potential EMT markers). So, 4b could be an anti-cancer promising drug. Although, in vivo experiments will be required to evaluate possible side effects.

Welcome to talk about 61-82-5, If you have any questions, you can contact Safari, F; Bayat, M; Nasri, S; Karami, S or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; AUTOPHAGY; APOPTOSIS; ROS; DESIGN in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics