Tag: M.W=0-100

Synthetic Route of 10570-40-8, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A solution of 4-methyl-1,2,4-triazole (0.55 g, 6.6 mmol) and CH3I (2.1 g, 15 mmol) in MeOH (1.5 mL) was heated in a pressure vessel (bath temperature 100 C) for 1 h. After cooling the solvent was evaporated. The residue was suspended in Et2O, filtered and dried to yield a gray powder (1:27 g, 85%). The spectroscopic data were as previously reported [49].

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 4-Methyl-4H-1,2,4-triazole is helpful to your research.

Reference:
Article; Laus, Gerhard; Kahlenberg, Volker; Wurst, Klaus; Schottenberger, Herwig; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 69; 9-10; (2014); p. 950 – 964;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C2H2N3Na

To a 500 mL three-necked flask was added compound 6 (55.7 g, 0.12 mol) and dry DMSO (400 mL), sodium triazole (45.5 g, 0.5 mol), stirred at room temperature for 1 h, heated to 80-100 C for 24 h, The raw material is finished (<1.5%). The reaction solution was cooled to room temperature, saturated ice brine (600 mL) was added, stirred, extracted with EA (250 mL x 2)Water (250 mL)Concentrated by steam to give 45.9 g of compound 7 as a yellow oil in a yield of 92.8% and a purity of 98.6%. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to Sodium 1,2,4-triazol-1-ide help many people in the next few years. Reference:
Patent; Shandong Luoxin Pharmaceutical Industry Company Limited; Liu, Xinquan; Zheng, Susu; Liu, Wei; (12 pag.)CN106146480; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 41253-21-8, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Compound 485Synthesis of (4-hydroxy-3,5-dimethoxyphenyl)(5-thiazol-2-yl-2-[1,2,4]thiazol-1-yl-phenyl)methanone; Compound 347 [(5-(thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone] (41.7 mg, 0.1 mmol) was dissolved in DMF (3 ml), and 1,2,4-triazole.Na (27 mg) was added thereto at room temperature. The mixture was reacted at 130 C. for 12 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, and diluted with an EtOAc solution. The organic layer was washed with a saturated ammonium chloride solution, water, and brine. The extracted organic layer was dried over anhydrous MgSO4, and the solid substance was filtered off. The filtrate was vacuum evaporated to remove the solvent. The resulting residue was purified by column chromatography (SiO2, CH2Cl2/MeOH=40/1?10/1) to obtain Compound 485 (78.7 mg, 73%) in a form of a white solid.1H NMR (CDCl3) delta 8.375 (brs, 1H), 8.345 (dd, J=10.5, 8.40, 1H), 8.173 (d, J=2.10 Hz, 1H), 7.965 (m, 2H), 7.773 (d, J=8.40 Hz, 1H), 7.476 (d, J=3.0 Hz, 1H), 3.857 (s, 6H). MS (ESI) m/z 409 (M++H).

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about Sodium 1,2,4-triazol-1-ide.

Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; US2009/275575; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1455-77-2, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A solution of 10 mmol of 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, or 4-hydroxypyrimidine-2,6-diamine in 50 mL of glacial acetic acid was slowly added to a solution of 20 mmol of phthalic anhydride or tetrachlorophthalic anhydride in 100 mL of glacial acetic acid. The colored solution was refluxed with constant stirring for 8 h at 100 °C (TLC monitoring; MeOH?CH2Cl2, 1 : 4) and poured into cold water. The colored precipitate was filtered off, dried in a vacuum desiccator over fused CaCl2, and recrystallized from DMSO. 2,2?-(1H-1,2,4-Triazole-3,5-diyl)bis[1H-isoindole-1,3(2H)-dione] (1). Yield 66percent, white solid, mp >300°C. IR spectrum, nu, cm?1: 1793, 1743 (C=O), 3298 (N?H),691 [delta(C?Carom)]. 1H NMR spectrum, delta, ppm: 7.60 d (4H, Harom), 7.69 d (4H, Harom), 11.13 s (1H, NH). Mass spectrum: m/z 360.01 [M + 1]+. Found, percent: C60.12; H 2.47; N 19.54. C18H9N5O4. Calculated, percent: C60.17; H 2.52; N 19.49.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3,5-Diamino-1,2,4-triazole, hurry up and to see.

Reference:
Article; Arif; Nayab, P. Sirajuddin; Rahisuddin; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1374 – 1380; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1374 – 1380,7;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 7170-01-6, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of (E)-N-(2-bromophenyl)-3-(3-methoxy-4-prop-2-ynoxy-phenyl)prop-2- enamide (0.2 g, 0.517 mmol, 1.0 equiv.) (4), 3-methyl- lH-l,2,4-triazole (0.258 g, 3.11 mmol, 6.0 equiv.), cuprous iodide (0.049 g, 0.258 mmol, 0.5 equiv.) and cesium carbonate (0.506 g, 1.55 mmol, 3.0 equiv.) in dimethyl sulfoxide (2 mL) was stirred at 100 C under nitrogen in microwave for 3 hours. The mixture was cooled to 25C, diluted with ethyl acetate (20 mL) and filtered. The filtrate was concentrated under reduced pressure to give a residue which was purified by preparative HPLC to give the desired product as a light yellow solid (5 mg, 2%); 1H NMR (CDCI3, 400 MHz) delta 9.89 (s, 1H), 8.63 (d, = 8.0 Hz, 1H), 8.37 (s, 1H), 7.64 (d, = 16.0 Hz, 1H), 7.46 (t, = 8.0 Hz, 1H), 7.35 (d, = 8.0 Hz, 1H), 7.21 (t, = 8.0 Hz, 1H), 7.15 (d, = 8.0 Hz, 1H), 7.08 – 7.05 (m, 2H), 6.36 (d, = 16.0 Hz, 1H), 4.82 (d, = 2.0 Hz, 2H), 3.94 (s, 3H), 2.60 (s, 3H), 2.55 (t, = 2.0 Hz, 1H); MS (ESI+) m/z 389.1 (M+H)+; 99% purity, RT 2.34 min (Method 8).

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3-Methyl-1H-1,2,4-triazole, hurry up and to see.

Reference:
Patent; SHIRE HUMAN GENETIC THERAPIES, INC.; MILLER, Thomas; PAPAIOANNOU, Nikolaos; (243 pag.)WO2018/144620; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 288-88-0, name is 1H-1,2,4-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 1H-1,2,4-Triazole

, adding 50 mmol of sodium methoxide into 50 mmol of 1, 2, 4-triazole (shown in the formula II)) and 50 mL of methanol solution, stirring for 60 minutes at 40 DEG c, and dropwise adding 60 mmol of bromobenzene, carrying out condensation reflux for 16 hours at the temperature of 90 DEG c, removing volatile matters in the reaction raffinate, washing the carbon tetrachloride, and filtering the solid impurities, and carrying out rotary evaporation to remove the washing solvent to obtain colorless liquid 1-phenyl -1,2,4-triazole 6.32g

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 288-88-0

Reference:
Patent; Nanjing Tech University; Guan Guofeng; He Yuting; Ding Jing; Li Xue; Wan Hui; (9 pag.)CN108484654; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 61-82-5, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 61-82-5, name is 1H-1,2,4-Triazol-5-amine, molecular formula is C2H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of aldehyde (1 mmol), dimedone (1 mmol), 3-amino-1,2,4-triazole (1 mmol), and [C4(H-DABCO)2][HSO4]4 (16 mg) washeated in an oil bath (90 C) under solvent-free conditions. Aftercompletion of the reaction, as identified by TLC, using n-hexane:EtOAc (7:3) as the eluent, 10 mL of water was added and stirredfor 10 min. The catalyst was dissolved in water and the solid wasfiltered off and washed with warm EtOH, to obtain the pure targetmolecule.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 1H-1,2,4-Triazol-5-amine.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 7170-01-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-chloro-8-methoxy-2- methylquinoline (100 mg, 0.481 mmol) was reacted with 3-methyl- IH-l, 2,· 4-triazole (46.0, 0.554 mmol) according to the synthesis of 4-(4-fluoro- 1 /Y-pyrazol- 1 -yl)-8-mcthoxy-2-mcthylquinolinc to give a mixture of the title compounds. MS (m/z): 255.3 [M+H+]

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 3-Methyl-1H-1,2,4-triazole.

Reference:
Patent; PHARVARIS B.V.; GIBSON, Christoph; SAUPE, Joern; AMBROSI, Horst-Dieter; HAUSTEDT, Lars Ole; (99 pag.)WO2019/101906; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 1H-1,2,3-Triazole

A mixture of 2,3-dichloro-5-nitropyridine (50 g, 259.08 mmol), 1H-1,2,3-triazole (19.683 g, 284.99 mmol), potassium carbonate (46.549 g, 336.81 mmol) and CH3CN (200 mL) was heated to 40 C. and stirred overnight. Ethyl acetate (500 mL) was added. The mixture was washed with water (500 mL*2) and brine (500 mL), dried over anhydrous Na2SO4, filtered, and concentrated to dryness under reduced pressure. The residue was triturated with DCM (100 mL), filtered, and the solid was collected to afford compound INT2A (40 g, 68%) as an off-white solid. LC-MS: (ES, m/z): [M+1]+ 225.9. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.40 (d, J=2.0 Hz, 1H), 9.15 (d, J=2.0 Hz, 1H), 8.33 (s, 2H).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1H-1,2,3-Triazole help many people in the next few years.

Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles

A suspension of 2-fluoro-6-iodobenzoic acid (300 mg, 1 .1 mmol), (1 R,2R)-N,N- dimethylcyclohexane-1 ,2-diamine (32 mg, 0.23 mmol), Cs2C03 (735 mg, 2.3 mmol), 1 H- 1 ,2,3-triazole (0.13 mL, 2.3 mmol), water (0.01 mL) in 1 ,4-dioxane (5 mL) was degassed under nitrogen for 10 mins. Cul (10.7 mg, 0.06 mmol) was added and the mixture was further degassed under nitrogen for 10 mins. The pressure tube was sealed and the mixture was heated to 100 for 18 hrs. After cooling, the reaction mixture was quenched with 13%wt NaCI in 2.5M hydrochloric acid (50 mL) and extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated in vacuo. The crude product was purified by chromatography on the Biotage Isolera Four (25 g column, 0 to 75% (10% AcOH in EtOAc) in heptane) to afford the title compound as an oil (140 mg). 1H NMR (250 MHz, MeOD) 7.94 (s, 2 H), 7.80 (m, 1 H), 7.62 (m, 1 H), 7.29 (m, 1 H).

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 288-36-8.

Reference:
Patent; C4X DISCOVERY LIMITED; BLANEY, Emma Louise; MARTIN, Barrie Phillip; NOWAK, Thorsten; WATSON, Martin John; (212 pag.)WO2016/34882; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics