Tag: 300-400

An Acidity Scale of Triazolium-Based NHC Precursors in DMSO was written by Li, Zhen;Li, Xin;Cheng, Jin-Pei. And the article was included in Journal of Organic Chemistry in 2017.Electric Literature of C17H24BF4N3O The following contents are mentioned in the article:

An acidity scale of triazolium-based N-heterocyclic carbene precursors was established by measuring 25 compounds’ (10a-15b) equilibrium acidities in DMSO solution using overlapping indicator method. The pK_a values ranged from 12.08 to 15.5, responding not only to the N-aryl motif, but also to the core structure. Excellent correlation was observed between the pK_a values and the Hammett substituent constants (σ_p). This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Electric Literature of C17H24BF4N3O).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Electric Literature of C17H24BF4N3O

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formal [3 + 4] Annulation of α,β-Unsaturated Acyl Azoliums: Access to Enantioenriched N-H-Free 1,5-Benzothiazepines was written by Fang, Chao;Lu, Tao;Zhu, Jindong;Sun, Kewen;Du, Ding. And the article was included in Organic Letters in 2017.Synthetic Route of C17H24BF4N3O The following contents are mentioned in the article:

An unprecedented formal [3 + 4] annulation of α,β-unsaturated acyl azoliums with 2-aminobenzenethiols has been utilized to synthesize enantioenriched N-H-free 1,5-benzothiazepines, which are recognized as privileged structures in numerous biol. active scaffolds. This protocol offers a rapid and direct pathway to access the target compounds with high enantioselectivities and has been applied in the concise synthesis of chiral drug (R)-thiazesim. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Synthetic Route of C17H24BF4N3O).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Synthetic Route of C17H24BF4N3O

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation [Erratum to document cited in CA162:137454] was written by Goodman, C. Guy;Walker, Morgan M.;Johnson, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2015.Product Details of 1631733-83-9 The following contents are mentioned in the article:

Some of the catalyst identifiers (A-G) used in the Supporting Information did not match those shown in the paper; the Supporting Information has been updated. The authors were made aware of several relevant publication involving enantioconvergent proline-catalyzed aldol reactions of chiral racemic electrophiles and provide the relevant citation information. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Product Details of 1631733-83-9).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeProduct Details of 1631733-83-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Highly enantioselective synthesis of fused bicyclic dihydropyranones via low-loading N-heterocyclic carbene organocatalysis was written by Li, Jun-Long;Fu, Lu;Wu, Jiao;Yang, Kai-Chuan;Li, Qing-Zhu;Gou, Xiao-Jun;Peng, Cheng;Han, Bo;Shen, Xu-Dong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Reference of 1631733-83-9 The following contents are mentioned in the article:

Highly diastereo and enantioselective [4+2] cycloadditions have been achieved between pyrrolidone-derived cyclic enones and α-haloaldehydes under mild conditions. Relying on extremely reactive in-situ generated chiral N-heterocyclic carbenes, this stereoselective annulation proceeded efficiently even on the gram scale with the catalyst loading as low as 0.025 mol% (250 ppm). A variety of cis-substituted bicyclic dihydropyranones can be produced in up to 96% yield with up to >99% ee. In addition, simple, inexpensive linear aldehydes such as n-propanal can be used directly in asym. cycloadditions via oxidative N-heterocyclic carbene organocatalysis with low catalyst loading. This method may provide an economical and practical approach for the asym. synthesis of medicinally relevant mols. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Reference of 1631733-83-9).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Reference of 1631733-83-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Dynamic Kinetic Asymmetric Cross-Benzoin Additions of β-Stereogenic α-Keto Esters was written by Goodman, C. Guy;Johnson, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2014.Application of 1631733-83-9 The following contents are mentioned in the article:

The dynamic kinetic resolution of β-halo α-keto esters via an asym. cross-benzoin reaction is described. A chiral N-heterocyclic carbene catalyzes the umpolung addition of aldehydes to racemic α-keto esters. The resulting fully substituted β-halo glycolic ester products are obtained with high levels of enantio- and diastereocontrol [e.g., PhCHO + β-bromo-α-keto ester I → II in >95% conversion, > 20:1 dr, 94:6 er]. The high chemoselectivity observed is a result of greater electrophilicity of the α-keto ester toward the Breslow intermediate. The reaction products are shown to undergo highly diastereoselective substrate-controlled reduction to give highly functionalized stereotriads. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Application of 1631733-83-9).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Application of 1631733-83-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation was written by Goodman, C. Guy;Walker, Morgan M.;Johnson, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2015.Related Products of 1631733-83-9 The following contents are mentioned in the article:

A dynamic kinetic resolution of β-halo α-keto esters, RO₂CC(:O)CHXR’ [R = Me, Bu-t, R’ = CH₂Ph, X = Cl; R = Bu-t, R’ = Ph, Me, CH₂CH₂Me, CH₂CCSiMe₃, (CH₂)₃OCH₂Ph; R = Bu-t, R’ = Ph, X = F] in an asym. homoenolate reaction is described. A chiral N-hetereocyclic carbene catalyzes the a³ → d³-umpolung addition of α,β-enals to racemic α-keto esters, forming γ-butyrolactones I [R¹ = Ph, C₆H₄OMe-4, C₆H₄Cl-4, C₆H₄Me-4, C₆H₄Me-3, thien-2-yl, furan-2-yl, CH:CHPh-(E), CO₃Et] and II [R² = Ph, Me, CH₂CH:CH₂, CH₂CCSiMe₃, (CH₂)₃OCH₂Ph, X = Cl; R = Ph, X = F] with three contiguous stereocenters. The addition occurs with high regio-, diastereo-, and enantiocontrol. This methodol. constitutes an intermol. DKR process to set three stereocenters during the key bond forming event. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Related Products of 1631733-83-9).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Related Products of 1631733-83-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics