Tag: 100-200

Yan, Wuming; Ye, Xiaohan; Weise, Keith; Petersen, Jeffrey L.; Shi, Xiaodong published an article in 2012, the title of the article was Synthesis of allene triazole through iron catalyzed regioselective addition to propargyl alcohols.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

Allene triazole derivatives were successfully synthesized through iron catalyzed regioselective triazole addition to tertiary propargyl alcs. The reaction proceeds under mild conditions, giving the desired allene-triazoles in good to excellent yields (up to 96%). The resulting allene-triazoles were confirmed by X-ray crystallog. and indicated improved stability. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to allene triazolyl preparation regioselective addition triazole propynol iron catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 31, 2016, Zhang, Hui; Dong, Dao-Qing; Wang, Zu-Li published an article.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Direct Synthesis of N-Unsubstituted 4-Aryl-1,2,3-triazoles Mediated by Amberlyst-15. And the article contained the following:

Aryltriazoles I [Ar is (un)substituted Ph, 2-thienyl] were prepared by reaction of nitrooelefins ArCH:CH2 with NaN3 promoted by Amberlyst-15. The method is highly efficient and the promoter can be recycled and reused up to eight times without any reduction in its catalytic activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole phenyl preparation nitrostyrene cycloaddition azide catalyst amberlyst 15, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Alves, Tania M. F.; Jardim, Guilherme A. M.; Ferreira, Marco A. B. published an article in 2021, the title of the article was A green metal-free “one-pot” microwave assisted synthesis of 1,4-dihydrochromene triazoles.HPLC of Formula: 5301-96-2 And the article contains the following content:

The synthesis of several 4-aryl-1,4-dihydrochromene-triazoles I (R1 = H, 8-Cl, 8-Br, 8-t-Bu, 6-OEt; R2 = Ph, 2-MeC6H4, 3-O2NC6H4, etc.) was achieved via a metal-free “one-pot” procedure using PEG400 as the sole solvent in an eco-friendly process. Using microwave irradiation, the triazole derivatives were obtained in good yields and short reaction times starting from readily accessible building blocks. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to dihydrochromene triazole preparation green chem microwave irradiation metal free, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On February 16, 2018, Ke, Fang; Xu, Yiwen; Zhang, Peng; Lin, Xiaoyan; Xu, Jianhua; Lin, Chen published a patent.Computed Properties of 5301-96-2 The title of the patent was Catalytic synthesis method of 4-aryl-1H-1,2,3-triazole derivative under microwave irradiation. And the patent contained the following:

A process for preparation of 4-aryl-1H-1,2,3-triazole derivative I (R = halo, Me, Et, i-Pr, Bu, nitro, acetyl, etc.) under microwave irradiation is disclosed. The process comprises cyclization of 2-nitroolefin with sodium azide under catalysis of trifluoromethanesulfonic acid (TfOH) in pyridine by microwave irradiation at 50-80° and 100-250 W for 10-30 min tp generate the product. The process has the advantages of mild reaction condition, simple operation, high yield and safety, low cost and environmental protection. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to aryl triazole derivative preparation catalytic cyclization microwave irradiation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 7, 2008, Kalisiak, Jaroslaw; Sharpless, K. Barry; Fokin, Valery V. published an article.Product Details of 5301-96-2 The title of the article was Efficient Synthesis of 2-Substituted-1,2,3-triazoles. And the article contained the following:

In this three-component reaction, alkynes undergo a CuSO4-catalyzed cycloaddition with sodium azide and formaldehyde to yield 2-hydroxymethyl-2H-1,2,3-triazoles, which are useful intermediates that can be readily converted to polyfunctional mols. The hydroxymethyl group can also be removed, providing convenient access to NH-1,2,3-triazoles. The reaction is exptl. simple and readily scalable. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Product Details of 5301-96-2

The Article related to triazole preparation, copper catalyst cycloaddition alkyne azide formaldehyde, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On February 29, 2016, Wu, Luyong; Wang, Xianghui; Chen, Yuxue; Huang, Qinglan; Lin, Qiang; Wu, Mingshu published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was 4-Aryl-NH-1,2,3-Triazoles via Multicomponent Reaction of Aldehydes, Nitroalkanes, and Sodium Azide. And the article contained the following:

4-Aryl-NH-1,2,3-triazoles are valuable compounds in organic chem. and pharmaceutical chem. In this paper, we describe a novel multicomponent reaction of aldehydes, nitroalkanes, and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles. In this transformation, it was found that both the slow addition of nitroalkane and the presence of NaHSO3/Na2SO3 are advantageous to promote the reaction results. Addnl., a series of aldehydes and nitro compounds were investigated. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to aryl triazole multicomponent preparation aldehyde nitroalkane sodium azide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Chavan, Omprakash S. published an article in 2022, the title of the article was Comparative study of various synthetic methods of 1,2,3-triazoles via click reaction: a mini review.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

Different derivatives of azides were condensed with different derivatives of terminal alkynes via click condensation reaction to form resp. derivatives of 1,2,3-triazoles in various reaction conditions. Present paper deals with the comparative study of synthesis of derivatives of 1,2,3-triazoles with respect to yield, reaction time and reaction conditions. All products were characterized by spectral data and elemental anal. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to alkyne azide condensation reaction green chem, triazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 31, 2010, Coelho, Alberto; Diz, Paula; Caamano, Olga; Sotelo, Eddy published an article.Category: triazoles The title of the article was Polymer-Supported 1,5,7-Triazabicyclo[4.4.0]dec-5-ene as Polyvalent Ligands in the Copper-Catalyzed Huisgen 1,3-Dipolar Cycloaddition. And the article contained the following:

New supported catalysts for the Huisgen’s [3+2] azide-alkyne cycloaddition have been prepared by immobilization of copper species on com. available polymeric matrixes incorporating the 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) template. The synergic exploitation of the exceptional copper chelating ability and basicity profile of the TBD framework, in addition to ensuring effective immobilization and stabilization of copper species, allows the implementation of three-component strategies. The new catalytic systems enabled the development of regioselective, efficient, modular, mild and eco-friendly multicomponent syntheses of diversely decorated 1,2,3-triazoles, contributing to expand the scope and versatility of the Cu-catalyzed Huisgen 1,3-dipolar cycloaddition The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to triazabicyclodecene ligand catalyst copper huisgen dipolar cycloaddition azide alkyne, triazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On December 31, 2016, Li, Xiaolong; He, Yun; Hai, Li; Zhang, Tao; Wu, Yong published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was A Novel Method to Synthesize 4-Aryl-1H-1,2,3-Triazoles and their Antihepatoma Activity. And the article contained the following:

A novel method for the preparation of 4-aryl-1H-1,2,3-triazoles (I) (aryl = R = Ph, 4-MeC6H4, 4-Cl-3-F3CC6H3, 4-morpholinyl-3-F3CC6H3, 4-piperidinyl-3-F3CC6H3, etc.) from arylglyoxaldoxime semicarbazones HON:CHCR:NNHC(O)NH2 with sodium dithionite and O2 was developed and found to be safer than the Huisgen azide-alkyne dipolar cycloaddition A total of 17 new 4-aryl-1H-1,2,3-triazoles were prepared and characterized by 1H NMR, 13C NMR and ESI-MS. Subsequently, their in-vitro antihepatoma activities were evaluated on human hepatoma QGY-7703, Bel-7402 and SMMC-7721 cell lines and mouse fibroblast cells L-929 by MTS assay. Among them, I (R = 4-Cl-3-F3CC6H3) exhibited excellent activity against QGY-7703 (GI50 = 0.0232 μM), while I (R = 4-morpholinyl-3-F3CC6H3, 4-piperidinyl-3-F3CC6H3) displayed good activity (GI50 = 0.103 μM and GI50 = 0.182 μM, resp.) against the growth of SMMC-7721 cell lines. Furthermore, these three triazoles showed slight selectivity of inhibition of hepatoma cell lines over normal cell line L-929. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to glyoxaldoxime semicarbazone aryl preparation cyclization, triazole aryl preparation antihepatoma activity, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tiwari, Vibha; Bingham, Jacob T.; Vyas, Shubham; Singh, Anand published an article in 2020, the title of the article was Intermolecular fluoroamination of allenes towards substituted vinyl fluorides.Product Details of 5301-96-2 And the article contains the following content:

A synthetic method towards fluorinated allylamines e.g., I, using allene precursors is reported. A variety of heterocyclic amines such as benzotriazole, 4-phenyl-1H-1,2,3-triazole, 5-phenyl-1H-1,2,3,4-tetrazole, etc. were employed as nucleophiles in a Selectfluor promoted intermol. fluoroamination reaction. This strategy provides a novel synthetic route to access vinyl fluorides with a vicinal amine moiety e.g., I. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Product Details of 5301-96-2

The Article related to allene selectfluor triazole regioselective fluoroamination, tetrazole allene selectfluor fluoroamination, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics