Tag: 100-200

Salicylic acid biosynthesis inhibitors increase chilling injury to maize (Zea mays L.) seedlings was written by Wang, Yang;Wen, Tingting;Huang, Yutao;Guan, Yajing;Hu, Jin. And the article was included in Plant Growth Regulation in 2018.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Salicylic acid (SA) is involved in plant response to many abiotic stresses. This study investigated the potential role of SA in regulating chilling tolerance of maize (Zea mays L.) seedlings. The results showed that chilling stress induced transient accumulation of free SA in maize plants, and stimulated the enzymic activities of phenylalanine ammonia-lyase (PAL) and benzoic acid-2-hydroxylase. However, seedlings pretreated with SA biosynthesis inhibitors (i.e., 2-aminoindane-2-phosphonic acid or 1-aminobenzotriazole) accumulated significantly less free and bound SA and suffered more severe cold injury. Together, these results indicated that the chilling-induced SA accumulation in maize seedlings was mainly attributed to the PAL pathway. SA application also induced chilling tolerance of maize seedlings; whereas, inhibition of SA biosynthesis significantly increased membrane peroxidation, decreased antioxidant enzymes activities, and resulted in growth retardation. Exogenous SA treatments reversed the effects of the SA inhibitors on chilling tolerance, indicating the important endogenous role of SA in inducing chilling tolerance of maize plants. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Assembly of a Complex Branched Oligosaccharide by Combining Fluorous-Supported Synthesis and Stereoselective Glycosylation using Anomeric Sulfonium Ions was written by Huang, Wei;Gao, Qi;Boons, Geert-Jan. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

There is an urgent need to develop reliable strategies for the rapid assembly of complex oligosaccharides. This paper presents a set of strategically selected orthogonal protecting groups, glycosyl donors modified by a (S)-phenylthiomethylbenzyl ether at C-2, and a glycosyl acceptor containing a fluorous tag, which makes it possible to rapidly prepare complex branched oligosaccharides of biol. importance. The C-2 auxiliary controlled the 1,2-cis anomeric selectivity of the various galactosylation. The orthogonal protecting groups, 2-naphthylmethyl ether (Nap) and levulinic ester (Lev), made it possible to generate glycosyl acceptors and allowed the installation of a crowded branching point. After the glycosylation, the chiral auxiliary could be removed using acidic conditions, which was compatible with the presence of the orthogonal protecting groups Lev and Nap, thereby allowing the efficient installation of 1,2-linked glycosides. The light fluorous tag made it possible to purify the compounds by a simple filtration method using silica gel modified by fluorocarbons. The set of building blocks was successfully employed for the preparation of the carbohydrate moiety of the GPI anchor of Trypanosoma brucei, which is a parasite that causes sleeping sickness in humans and similar diseases in domestic animals. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats was written by Parrish, Karen E.;Mao, Jialin;Chen, Jacob;Jaochico, Allan;Ly, Justin;Ho, Quynh;Mukadam, Sophie;Wright, Matthew. And the article was included in Biopharmaceutics & Drug Disposition in 2016.Related Products of 1614-12-6 This article mentions the following:

1-Aminobenzotriazole (ABT) is a non-isoform specific, time-dependent inhibitor of cytochrome P 450 (CYP) enzymes used extensively in preclin. studies to determine the relative contribution of oxidative metabolism Although ABT has been widely used, the extent and duration of its inhibitory effect is not well understood. The purpose of this study is to characterize ABT inhibition of CYP in rats at both the hepatic and intestinal levels. In vivo studies using midazolam (p.o. and i.v.), as a probe for CYP activity, demonstrated that CYP inhibition was not complete even at the highest dose (300 mg/kg). Addnl. in vivo studies demonstrated that even at 26 h following ABT administration, there was significant CYP inhibition remaining. In vitro studies, conducted in both rat liver microsomes and rat hepatocytes, confirm that ABT is a time-dependent inhibitor of rat CYP orthologs. However, in rat liver microsomes, there was more than 15% CYP activity remaining following a 60 min preincubation at 2 mM ABT and 5-10% of CYP activity was remaining in rat hepatocytes suspended in rat plasma following a 60 min preincubation at 2 mM ABT. 1-Aminobenzotriazole is a useful tool in elucidating the oxidative component of metabolism in preclin. species; however, conclusions made from the preclin. use of ABT should not operate under the assumption that CYP enzymic activity is completely inhibited. Copyright © 2016 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Related Products of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Related Products of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis, structure, and fungicidal activity of triorganotin (4H-1,2,4-triazol-4-yl)benzoates was written by Li, Fang-Lin;Dai, Bin;Song, Hai-Bin;Mi, Na;Tang, Liang-Fu. And the article was included in Heteroatom Chemistry in 2010.Application of 157069-48-2 This article mentions the following:

A series of triorganotin (4H-1,2,4-triazol-4-yl)benzoates have been synthesized by the reaction of 4-(4H-1,2,4-triazol-4-yl)benzoic acid and 3-(4H-1,2,4-triazol-4-yl)benzoic acid with (R₃Sn)₂O (R = Et, n-Bu and Ph) or R’₃SnOH (R’ = p-tolyl and cyclohexyl). The mol. structure of tri(p-tolyl)tin 3-(4H-1,2,4-triazol-4-yl)benzoate determined by x-ray crystallog. displays that the tin atom adopts a five-coordinate distorted trigonal bipyramidal geometry with the carboxyl oxygen atom and the nitrogen atom on 1-position of triazole ring occupying the apical position. Moreover, this complex forms a polymeric chain by the intermol. Sn-N interactions. All these complexes show good antifungal activities in vitro against Alternaria solani, Cercospora arachidicola, Gibberella zeae, Physalospora piricola, and Botrytis cinerea. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 20:411-417, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20566. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Application of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Application of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Biodegradation and detoxification of neonicotinoid insecticide thiamethoxam by white-rot fungus Phanerochaete chrysosporium was written by Chen, Anwei;Li, Wenjie;Zhang, Xiaoxiao;Shang, Cui;Luo, Si;Cao, Ruoyu;Jin, Doudou. And the article was included in Journal of Hazardous Materials in 2021.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

The extensive use of neonicotinoid pesticides in the past two decades caused serious impacts on many kinds of living beings. Therefore, it has been strongly suggested to detoxify and eliminate neonicotinoids′ residual levels in environment. Here, the degradation and detoxification of thiamethoxam (THX) by white-rot fungus Phanerochaete chrysosporium was conducted. Results shown that P. chrysosporium can tolerate THX and degraded 49% of THX after incubation for 15 days, and then 98% for 25 days at the initial concentration of 10 mg/L, which indicates the excellent degradation ability of this fungus to THX. Based on the byproducts identified, THX underwent dechlorination, nitrate reduction, and C-N cleavage between the 2-chlorothiazole ring and oxadiazine. (Z)-N-(3-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide and 3-methyl-1,3,5-oxadiazinan-4-imine were identified as the main metabolites. The impacts of THX and its corresponding degradation intermediates on the growth of E. coil and Microcystis aeruginosa as well as the germination of rape and cabbage demonstrated that P. chrysosporium effectively degrades THX into metabolites and reduces its biotoxicity. The present work demonstrates that P. chrysosporium can be effectively used for degradation and detoxification of THX. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Additive-Induced Supramolecular Isomerism and Enhancement of Robustness in Co(II)-Based MOFs for Efficiently Trapping Acetylene from Acetylene-Containing Mixtures was written by Ye, Yingxiang;Chen, Shimin;Chen, Liangji;Huang, Jitao;Ma, Zhenlin;Li, Ziyin;Yao, Zizhu;Zhang, Jindan;Zhang, Zhangjing;Xiang, Shengchang. And the article was included in ACS Applied Materials & Interfaces in 2018.Product Details of 157069-48-2 This article mentions the following:

Although supramol. isomerism in metal-organic frameworks (MOFs) would offer a favorable platform for in-depth exploring their structure-property relationship, the design and synthesis of the isomers are still rather a challenging aspect of crystal engineering. Here, a pair of supramol. isomers of Co(II)-based MOFs (FJU-88 and FJU-89) can be directionally fabricated by rational tuning the additives. In spite of the fact that the isomers have the similar Co₃ secondary building units and organic linkers, they adopt distinct networks with acs and snw topologies, resp., which derive from the conformational flexibility of the organic ligands. It is noteworthy that the porous structure of FJU-88 would be collapsed after removal of the solvent from the pores. But FJU-89a shows permanent porosity accompanied with unusual hierarchical micro- and mesopores and superior gas selective adsorption performance. In addition, FJU-89a can efficiently trap C₂H₂ from C₂H₂/CO₂ and C₂H₂/CH₄ mixture gases through fixed-bed dynamic breakthrough experiments In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Product Details of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Product Details of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Multi-step Phase Transformation from Metal-Organic Frameworks to Inorganic Compounds for High-Purity Th(IV) Generation was written by Huang, Yi-wei;Feng, Han;Xiong, Xiao-hong;Luo, Feng. And the article was included in Inorganic Chemistry in 2022.Synthetic Route of C9H7N3O2 This article mentions the following:

The generation of high-purity thorium is the precondition for next-generation nuclear energy; however, this remains a challenging task. To this end, the authors present herein an ultrasimple technique with the combination of crystallization plus phase transformation. Crystallization into ECUT-68 is found to show almost 100% selective uptake of Th(IV) over rare earth and UO₂²⁺ ions, while multistep phase transformation from metal-organic frameworks (MOFs) to inorganic compounds is found to directly generate inorganic Th(IV) compound and then Th(IV) solution, suggesting its superior application in the generation of high-purity thorium. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Synthetic Route of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Synthetic Route of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Catalyst-free one-pot, four-component approach for the synthesis of di- and tri-substituted N-sulfonyl formamidines was written by Liu, Ai-Ran;Zhang, Lei;Li, Jiao;Wusiman, Abudureheman. And the article was included in RSC Advances in 2021.Electric Literature of C5H7N3O2 This article mentions the following:

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN₃, Et propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural anal. of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogs only formed E-isomers. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Electric Literature of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Electric Literature of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lanthanide-based coordination compounds based on 4-(4-carboxyphenyl)-1,2,4-triazole: synthesis, structures, Hirshfeld surface and luminescence properties was written by Liu, Qing-Ling;Yang, Li-Jing;Luo, Yang-Hui;Sun, Bai-Wang. And the article was included in New Journal of Chemistry in 2016.Synthetic Route of C9H7N3O2 This article mentions the following:

Four novel lanthanide compounds based on the 4-(4-carboxyphenyl)-1,2,4-triazole ligand (Hcpt), {[Pr₂(cpt)₄(H₂O)₁₀]·10H₂O·2ClO₄} (1), {[Ln(cpt)₂(H₂O)₂(OH)]·4H₂O}_n (Ln = Er (2), Lu (3)), and {[Sm(cpt)₂(CH₃CH₂OH)(H₂O)₃]·ClO₄}_n (4), were obtained under hydrothermal conditions and further characterized by elemental anal., single-crystal x-ray diffraction and TGA. Compound 1 exhibits a discrete dinuclear structure constructed by one cpt^– ligand coordinated to two Pr³⁺ ions and another cpt^– ligand coordinated to more than one Pr³⁺ ion. Compounds 2 and 3 are isomorphous and every cpt^– ligand coordinates to two Ln³⁺ ions, resulting in a polymeric 1-dimensional chain structure. Different from the above compounds, the nitrogen atoms of triazole are also involved in the coordination of compound 4. One cpt^– ligand coordinates to two Sm³⁺ ions and another cpt^– ligand coordinates to more than one Sm³⁺ ion, meanwhile, the nitrogen atoms of triazole coordinate to the 3rd Sm³⁺ ion, resulting in a 2-dimensional polymeric network structure. The luminescence properties of compound 4 were characterized, and it exhibited characteristic Sm³⁺ emission in the yellow region. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Synthetic Route of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A new family of 3d-4f heterometallic coordination polymers assembled with 1H-1,2,3-triazole-4,5-dicarboxylic acid: syntheses, structures and magnetic properties was written by Zou, Ji-Yong;Xu, Na;Shi, Wei;Gao, Hong-Ling;Cui, Jian-Zhong;Cheng, Peng. And the article was included in RSC Advances in 2013.Synthetic Route of C4H3N3O4 This article mentions the following:

Five isostructural copper(II)-lanthanide(iii) heterometallic coordination polymers (CPs), {[Cu₂Ln(TDA)₂Cl(H₂O)₄]·2H₂O}_n [Ln = Gd (Cu-Gd), Tb (Cu-Tb), Dy (Cu-Dy), Ho (Cu-Ho) and Er (Cu-Er)] (H₃TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid), were synthesized under solvothermal conditions and structurally characterized. In these CPs, two neighboring Cu(II) ions are connected via one μ₂-Cl to form [Cu₂Cl]³⁺ units, which are further linked into a copper chain through bridging TDA^3-. The neighboring copper chains are further connected by lanthanide to form a two-dimensional structure with sql topol. The magnetic properties of the five isostructural heterometallic CPs were studied as well. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics