Tag: 100-200

Triclosan transformation and impact on an elemental sulfur-driven sulfidogenic process was written by Zhang, Liang;Wu, Dan;Liang, Jialin;Wang, Li;Zhou, Yan. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Product Details of 1614-12-6 This article mentions the following:

Elemental sulfur reduction has recently been demonstrated to be a promising sulfidogenic process for cost-effective treatment of various wastewaters. However, it remains unknown if sulfur reduction is capable of pharmaceuticals and personal care products (PPCPs) removal. Thus, this study investigated the feasibility of such process to remove PPCPs and how PPCPs influence the system performance during a long-term operation. Triclosan (TCS), a typical broad-spectrum antibacterial agent and a ubiquitous emerging organic contaminant in environments was chosen as the model compound Results showed that TCS was removed principally via fast sorption followed by slow biodegradation Amides, polysaccharides and hydroxyl groups in extracellular polymeric substances (EPS) provided adsorption sites. Both metabolism and co-metabolism of TCS with organic carbon removal were responsible for TCS biodegradation Reductive dechlorination and hydroxylation of TCS were inferred during TCS biodegradation The genera Georgenia, Soehngenia, Comamonas, Pseudomonas, Desulfovibrio and Sulfurospirillum were the potential TCS degraders in the sulfur-reducing system. Addnl., the presence of TCS at environmentally relevant concentrations did not neg. impact the performance of organic carbon removal, but altered functional bacteria groups (i.e. fermentative and sulfur-reducing genera). In summary, the sulfur-reducing system could be sufficiently robust to transform organohalide antimicrobials of PPCPs (e.g. triclosan) without compromising the performance. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Series of novel 3D microporous heterometallic 3d-4f coordination frameworks with (5,6)-connected topology. Synthesis, crystal structure and magnetic properties was written by Chen, Chu Jun;Wang, Ning;Long, Yi;Gao, Jin Ying;Xie, Wei Ping;Ran, Xing Rui;Yue, Shan Tang. And the article was included in CrystEngComm in 2013.Application of 4546-95-6 This article mentions the following:

The hydrothermal reaction of rare earth nitrates, CuCN, 1H-1,2,3-triazole-4,5-dicarboxylic acid (H₃tda), and isonicotinic acid (Hina) resulted in the formation of a new series of 3d-4f heterometallic coordination polymers [LnCu(tda)(ina)₂(H₂O)]·3H₂O (Ln = Eu (1), Tb (2), Gd (3), Dy (4), Ho (5), H₃tda = 1H-1,2,3-triazole-4,5-dicarboxylic acid, Hina = isonicotinic acid). Complexes 1–5 are isostructural and structurally characterized by elemental anal., FT-IR spectroscopy, thermogravimetric anal. (TGA), and single-crystal powder x-ray diffraction (PXRD). Single-crystal x-ray diffraction anal. reveals that the metal cations in these compounds are firstly interconnected by H₃tda ligands to produce a carpet-shaped heterometallic ring [Ln₂(tda)₂Cu₄], and then pillared by bridging Hina mols. to form the 3D layer-pillared porous Ln(III)-Cu(II) heterometallic coordination polymers. In addition, the magnetic properties of 1–5 were also investigated in detail. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Application of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An in Vitro Digestion Test That Reflects Rat Intestinal Conditions To Probe the Importance of Formulation Digestion vs First Pass Metabolism in Danazol Bioavailability from Lipid Based Formulations was written by Anby, Mette U.;Nguyen, Tri-Hung;Yeap, Yan Yan;Feeney, Orlagh M.;Williams, Hywel D.;Benameur, Hassan;Pouton, Colin W.;Porter, Christopher J. H.. And the article was included in Molecular Pharmaceutics in 2014.Product Details of 1614-12-6 This article mentions the following:

The impact of gastrointestinal (GI) processing and first pass metabolism on danazol oral bioavailability (BA) was evaluated after administration of self-emulsifying drug delivery systems (SEDDS) in the rat. Danazol absolute BA was determined following oral and intraduodenal (ID) administration of LFCS class IIIA medium chain (MC) formulations at high (SEDDS_H-III) and low (SEDDS_L-III) drug loading and a lipid free LFCS class IV formulation (SEDDS-IV). Experiments were conducted in the presence and absence of ABT (1-aminobenzotriazole) to evaluate the effect of first pass metabolism A series of modified in vitro lipolysis tests were developed to better understand the in vivo processing of SEDDS in the rat. Danazol BA was low (<13%) following oral and ID administration of either SEDDS. Increasing drug loading, ID rather than oral administration, and administration of SEDDS-IV rather than SEDDS-III led to higher oral BA. After pretreatment with ABT, however, danazol oral BA significantly increased (e.g., 60% compared to 2% after administration of SEDDS_L-III), no effect was observed on increasing drug loading, and differences between SEDDS-III and -IV were minimal. In vitro digestion models based on the lower enzyme activity and lower dilution conditions expected in the rat resulted in significantly reduced danazol precipitation from SEDDS-III or SEDDS-IV on initiation of digestion. At the doses administered here (4-8 mg/kg), the primary limitation to danazol oral BA in the rat was first pass metabolism, and the fraction absorbed was >45% after oral administration of SEDDS-III or SEDDS-IV. In contrast, previous studies in dogs suggest that danazol BA is less dependent on first pass metabolism and more sensitive to changes in formulation processing. In vitro digestion models based on likely rat GI conditions suggest less drug precipitation on formulation digestion when compared to equivalent dog models, consistent with the increases in in vivo exposure (fraction absorbed) seen here in ABT-pretreated rats. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Design, structure and luminescent properties of a novel two-dimensional Cd(II) coordination polymer constructed from in situ generated 1-methyl-2-(3H-[1-3]triazol-4-yl)-1H-benzoimidazole was written by Sun, Feng;Yin, Zheng;Sun, Chen-Guang;Kurmoo, Mohamedally;Zeng, Ming-Hua. And the article was included in Inorganic Chemistry Communications in 2014.Product Details of 4546-95-6 This article mentions the following:

A cadmium(II) coordination polymer, namely {[Cd₅(Lⁿ)₆Cl₄]·2H₂O}_n (1, HLⁿ = 1-methyl-2-(3H-[1-3]triazol-4-yl)-1H-benzoimidazole), was constructed from in situ generated HLⁿ under hydrothermal condition. The unsuccessful synthesis of 1 under similar synthesis condition using HLⁿ as reactant suggests the in situ reaction is crucial for the assembly of the compound Crystallog. study reveals that 1 processes layer structure in which chains of [Cd₃(Lⁿ)₄Cl₄]^2 – were connected by a pair of Cd ions. These layers further stack in an AAA model to form a 3D supramol. framework and hydrogen bonding as well as π-π interaction were formed between adjacent layers to stabilize the framework. TGA indicates that 1 is highly thermally stable up to ∼380°. The luminescence of 1 in the solid state which may be assigned to intraligand transition shows a blue shift of 16 nm compared to that of HLⁿ·HCl. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Product Details of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Product Details of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of acyl- and vinyl-substituted 1,2,3-triazoles was written by Vereshchagin, L. I.;Tikhonova, L. G.;Maksikova, A. V.;Gavrilov, L. D.;Gareev, G. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1979.Recommanded Product: 40594-98-7 This article mentions the following:

Acyltriazoles I [R = Ph, Me, HO, p-MeOC₆H₄, Me₂CH, 3,4-(MeO)₂ C₆H₃, R¹ = HOCMe₂, CH₂OH, CH₂C(OH)Me₂, Bz, Ph, H, CO₂H, p-MeC₆H₄, p-MeOC₆H₄, R² = H, CH₂CH₂Cl] were prepared in 52-91% yields by cyclization of RCOCCR¹, prepared by oxidation of RC(OH)CCR¹, with R²N₃. Triazoles II (R = Ph, EtO, R¹ = HOCMe₂, Bz, Ph, H) were obtained in 30-59% yields by treatment of the corresponding RCOCCR¹ with I (R = R¹ = Ph, R² = H). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Recommanded Product: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Recommanded Product: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Flexible Mixed-Spin Kagome ́Coordination Polymers with Reversible Magnetism Triggered by Dehydration and Rehydration was written by Zhang, Wei-Xiong;Xue, Wei;Chen, Xiao-Ming. And the article was included in Inorganic Chemistry in 2011.COA of Formula: C4H3N3O4 This article mentions the following:

Two new two-dimensional (2D) heterometal coordination polymers [Cu₂M(tzdc)₂(H₂O)₂]·2H₂O [M = Fe²⁺ (1) or Mn²⁺ (2); tzdc^3- = 1,2,3-triazole-4,5-dicarboxylate] were assembled by using the tzdc^3-, Cu²⁺, and Fe²⁺/Mn²⁺ ions. Single-crystal x-ray anal. reveals that the two compounds consist of mixed-spin microporous Kagome layers, which are packed into three-dimensional structures by H bonding and interlayer weak Cu···O interactions. When heated, they can release in a stepwise manner the uncoordinated and coordinated H₂O mols. to produce dehydrated phases (1‘ and 2‘), resp., which are stable up to ∼300°. The structures of 1‘ and 2‘ were determined by powder x-ray diffraction anal., which reveals a change in the coordination sphere of Fe²⁺/Mn²⁺ ions from an octahedron to an elongated 4+2 form, and a microporous-to-nonporous structural transformation involving intralayer wrinkling and interlayer superimposition. When the dehydrated samples are exposed to air, they can return to the hydrated phases quickly by adsorption of H₂O mols. Accordingly, a reversible change in magnetism between the ferrimagnetic character of the hydrated samples and the suppressed ferrimagnetic character of the dehydrated samples was found in this reversible dehydration and rehydration. These facts indicate these 2-dimensional heterometal coordination polymers are unique flexible 2-dimensional dynamic magnetic materials. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6COA of Formula: C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeCOA of Formula: C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quest for the Ncb-type Metal-Organic Framework Platform: A Bifunctional Ligand Approach Meets Net Topology Needs was written by Chen, Di-Ming;Zhang, Nan-Nan;Tian, Jia-Yue;Liu, Chun-Sen;Du, Miao. And the article was included in Inorganic Chemistry in 2017.Computed Properties of C9H7N3O2 This article mentions the following:

A custom-designed bifunctional ligand was used to connect an in situ formed Co₃(OH) cluster affording a porous metal-organic framework {(CoCl₄)_0.25[Co₃(μ₃-OH)(CPT)_4.5](DMA)₅(DEF)(MeCN)₆}_n where HCPT = 4-(p-Carboxyphenyl)-1,2,4-triazole, DMA = N,N-dimethylacetamide, and DEF = N,N-diethylformamide, which represents the first case of ncb-type networks constructed from a single kind of ditopic ligand. Noticeably, the activated MOF shows high volumetric C₂H₂ uptake and excellent adsorption selectivity for C₂H₂/CO₂ separation at room temperature with a low sorption heat. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Computed Properties of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Computed Properties of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Azido-Directed Formation of An Unprecedented Mn(II)-Organic Framework with Nanoscale Cubic Cage Units was written by Zhao, Jiong-Peng;Zhao, Ran;Song, Wei-Chao;Yang, Qian;Liu, Fu-Chen;Bu, Xian-He. And the article was included in Crystal Growth & Design in 2013.Name: 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

A bcu topol. three-dimensional Mn(II)-organic framework [Mn₂₂(N₃)₈(L)₁₂(H₂O)₂₆·5H₂O]_∞ (1) (L = 1,2,3-triazole-4,5-dicarboxylate) based on an unprecedented nanoscale cage was hydrothermally synthesized. Dominating antiferromagnetic interactions were detected between the Mn^II ions in 1. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Name: 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Name: 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A 3D-diamond-like metal-organic framework: Crystal structure, nonlinear optical effect and high thermal stability was written by Wang, Lihua;Ye, Yingxiang;Zhang, Liuqin;Chen, Qianhuo;Ma, Xiuling;Zhang, Zhangjing;Xiang, Shengchang. And the article was included in Inorganic Chemistry Communications in 2015.Recommanded Product: 157069-48-2 This article mentions the following:

A new metal-organic framework [Zn(cpt)(ATZ)]_n (1, HATZ = 5-amino-1H-tetrazol, Hcpt = 4-(4H-1,2,4-Triazol-4-yl)benzoic acid), has been solvothermally synthesized and structurally characterized by single crystal X-ray diffraction. Structural anal. shows that compound 1 is a three-dimensional (3D) framework with 3-fold interpenetrated diamond topol. where the Zn(II) centers are all 4-coordinated. Compound 1 exhibits high thermal stability up to 370 °C, and weak second-order nonlinear optical coefficient as ca. 0.13 times as that of potassium dihydrogen phosphate (KDP), and also displays blue photoluminescence at room temperature In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Recommanded Product: 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Recommanded Product: 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Colorimetric Dual Sensors of Metal Ions Based on 1,2,3-Triazole-4,5-Dicarboxylic Acid-Functionalized Gold Nanoparticles was written by Mondal, Palash;Yarger, Jeffery L.. And the article was included in Journal of Physical Chemistry C in 2019.Product Details of 4546-95-6 This article mentions the following:

A simple, rapid, selective, and cost-effective colorimetric assay for Cr³⁺ and Eu³⁺ ion detection has been developed using functionalized gold nanoparticles. Gold nanoparticles (AuNPs) were prepared using HAuCl₄, where sodium citrate is a reducing agent as well as a capping agent, and then functionalized with 1,2,3-triazole-4,5-dicarboxylic acid (TADA). Fourier transform IR (FTIR) and Raman spectroscopies suggested that TADA was functionalized on the surface of AuNPs through the N atom of triazole. The TADA-functionalized gold nanoparticles (TADA@AuNPs) simultaneously detect Cr³⁺ and Eu³⁺ ions from aqueous solution and showed different responses to the two metal ions (Cr³⁺ and Eu³⁺) based on an aggregation-induced color change of AuNPs. They showed a color change from wine red to blue, which was easily detected by the naked eye, as well as by UV-visible and FTIR spectroscopies. The surface plasmon resonance absorbances of Cr³⁺ and Eu³⁺ are 633 and 671 nm, resp., when Cr³⁺ and Eu³⁺ react with TADA@AuNPs and showed good linearity with Cr³⁺ and Eu³⁺ concentrations with detection limits 5.89 nM and 4.30 μM, resp. (S/N = 3). The TADA@AuNPs showed excellent selectivity toward Cr³⁺ and Eu³⁺ compared to those of the 16 different metal ions. We had also tested the selectivity of TADA@AuNPs toward Eu³⁺ compared to that of the other 10 lanthanide systems. Optimal detection was achieved toward Cr³⁺ and Eu³⁺ ions in the pH range 4-10. In addition, TADA@AuNPs were applied to detect Cr³⁺ and Eu³⁺ ions from lake water showing low interference. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Product Details of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Product Details of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics