Synthetic Route of 41253-21-8, These common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Prepare a dry, clean 500mL glass four-port bottle, equipped with a suitable mechanical stirrer, condenser tube and thermometer, and check the airtightness before adding the material.95 g of 2′-chloro-2,4-difluoroacetophenone (compound 5) (0.5 mol, 1 eq), 69 g was added to the reaction flask under N2 protection.Sodium 1,2,4-triazolyl (Compound 6) (0.75 mol, 1.5 eq) and 200 mL of DMF were stirred and the temperature of the reaction solution was raised to 70-75 C. The reaction was stirred for 12 h. After the reaction was completed, the reaction system was cooled to At room temperature, 400 ml of water was added, and then 600 ml of ethyl acetate was added for extraction. The separated ethyl acetate phase was washed with 300 ml of water and the organic phase was separated. The solvent was distilled off under reduced pressure and 300 ml of n-heptane was added for recrystallization to give a white solid. Powdery Compound 1 84.8 g (yield: 76.0%).
Statistics shows that Sodium 1,2,4-triazol-1-ide is playing an increasingly important role. we look forward to future research findings about 41253-21-8.
Reference:
Patent; Jiangsu Hengsheng Pharmaceutical Co., Ltd.; Wang Xilin; Yu Yuanyuan; (8 pag.)CN107746388; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics