Synthetic Route of 7170-01-6, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
General procedure: To a mixture of 33 (126.3 mg,0.295 mmol) and 1H-pyrazole (24.1 mg, 0.353 mmol) in DMF(4 mL) was added K2CO3 (48.8 mg, 0.353 mmol). The mixturewas stirred at 90C for 30 min and then poured into water.The mixture was extracted with EtOAc, washed with water and saturated aqueous NaCl, dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified bycolumn chromatography (silica gel, hexane-ethyl acetate,19 : 1 to 0 : 100) to afford 14 (102 mg, 0.222 mmol, 75%) as awhite solid after trituration with hexane-ethyl acetate (5 : 1).1H-NMR (300 MHz, DMSO-d6) delta: 1.02 (3H, s), 1.36 (3H,s), 4.86 (1H, d, J=8.3 Hz), 5.34 (1H, s), 6.75-6.81 (1H, m),7.23-7.33 (2H, m), 7.48-7.58 (2H, m), 7.76 (1H, d, J=7.5 Hz),8.05 (1H, d, J=1.5 Hz), 8.46 (1H, s), 9.02-9.14 (2H, m), 9.37(1H, d, J=7.5 Hz). MS (ESI/APCI) m/z 461.1 [M+H]+. HPLCpurity: 100%. mp 241C.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3-Methyl-1H-1,2,4-triazole, hurry up and to see.
Reference:
Article; Mikami, Satoshi; Kawasaki, Masanori; Ikeda, Shuhei; Negoro, Nobuyuki; Nakamura, Shinji; Nomura, Izumi; Ashizawa, Tomoko; Kokubo, Hironori; Hoffman, Isaac Dylan; Zou, Hua; Oki, Hideyuki; Uchiyama, Noriko; Hiura, Yuuto; Miyamoto, Maki; Itou, Yuuki; Nakashima, Masato; Iwashita, Hiroki; Taniguchi, Takahiko; Chemical and Pharmaceutical Bulletin; vol. 65; 11; (2017); p. 1058 – 1077;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics