Something interesting about 1H-1,2,4-Triazol-5-amine

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 61-82-5

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 61-82-5, name is 1H-1,2,4-Triazol-5-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 1H-1,2,4-Triazol-5-amine

A. Synthesis of OTA: Formation of OTA solution in concentrated sulfuric acid144 g (1.714 mol) of 3-amino-1,2,4-triazole (commercial ATA) are added to 1.2 L of concentrated sulfuric acid (98% by weight commercial concentrated sulfuric acid) precooled to 5 .The mixture is cooled to 5 & lt; 0 & gt; C.150 g (2.174 mol) of sodium nitrite (NaNO2) is gradually added at this temperature of 5 . Do not exceed 10 .At the end of the introduction of sodium nitrite, the reaction medium is gradually heated to 100 under a temperature gradient of 12 / h. When the temperature reaches 100 DEG C (after about 8 hours), the reaction medium is stirred for 2 hours (at the temperature of 100 DEG C).The progress of the reaction is monitored by high performance liquid chromatography (HPLC) after external calibration (using commercial OTA). The OTA yield is measured on samples taken at different temperatures (diluted with water to stop the reaction)

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 61-82-5

Reference:
Patent; Hercules; Yurenko; Herve, Gregoire; Jacob, Gi; Kanyong, Gi; Busay, Jang Marque; (13 pag.)KR2016/28405; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics