In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows. Recommanded Product: 7170-01-6
131.1. 4-(3-methyl-[1,2,4]triazol-1-yl)-benzaldehyde To a solution of 4-fluorobenzaldehyde (3.63 g) and 3-methyl-1H-1,2,4-triazole (2.92 g; prepared according to US 2006/293304) in dry DMF (35 mL) was added K2CO3 (24.25 g) at rt. The reaction mixture was stirred at 120 C. overnight, then cooled to rt and diluted with EA and water. The aq. layer was extracted with EA (2*) and the combined org. layers were washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The title compound was obtained, after purification by CC (Hept/EA 80:20 to 50:50), as a yellow solid (36% yield). 1H NMR (CDCl3) delta: 10.06 (s, 1H); 8.58 (s, 1H); 8.04 (d, J=8.0 Hz, 2H); 7.88 (d, J=8.0 Hz, 2H); 2.53 (s, 3H).
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bur, Daniel; Gude, Markus; Hubschwerlen, Christian; Panchaud, Philippe; US2013/96119; (2013); A1;,
1,2,3-Triazole – Wikipedia,
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