Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 4928-87-4
A solution of 1H-1,2,4-triazole-3-carboxylic acid (0.072 g, 0.64 mmol), N- [(dimethylamino)(3H-[1 ,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-lambda/- methylmethanaminium hexafluorophosphate (0.243 g, 0.64 mmol) and lambda/-ethyl-lambda/- isopropylpropan-2-amine (0.205 mL, 1.17 mmol) in DMF (1.5 mL) was stirred for 15 minutes under argon. Finally, 3″-fluoro-3,2I:3l,4″-terpyridine-5′,6I-diamine (Intermediate 1 , 0.15 g, 0.53 mmol) in DMF (3 mL) was added and the mixture was stirred at room temperature for 20 hours. The solvent was evaporated and the crude mixture was purified by silica gel flash chromatography (90:10 dichloromethane/methanol) to give the title compound (0.070 g, 35% of yield). ESI/MS m/e: 377 ([M+H]+, C18H13FN8O).
The synthetic route of 4928-87-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2007/39297; (2007); A1;,
1,2,3-Triazole – Wikipedia,
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