New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles
(R)-1-benzyl-5-methyl-1,4-diazepane (14.7 mmol)3.66 g of 5-methyl-2-(2 H-1,2,3-triazol-2-yl)benzoic acid18.03 mg)was dissolved in DMF and 2.43 g H0Bt (18.55 mmol), 6 mL TEA (42.75 mmol), 3.45 g EDC (17.99 mmo1) C, reaction 2h.A saturated solution of NaHCO3 and EA were added and the aqueous layer was washed three times with EA and the organic layers were combined.The organic layer was washed with citric acid solution, and the product was fully salified into aqueous phase. The aqueous phase was washed with EA after adding sodium carbonate to adjust pH> 9 and EA was washed three times. The combined organic layer was washed with saturated brine, dried with MgSO4, And EA (4: 1) (yield: 98.36%
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Reference:
Patent; WUHAN JIAYU TECHNOLOGY CO. LTD; ZHANG, GU ISEN; LIU, BIFENG; ZHOU, YAN; (18 pag.)CN103923068; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics