One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 464-48-2, Name is (-)-Camphor, formurla is C10H16O. In a document, author is Abedinifar, Fahimeh, introducing its new discovery. Application In Synthesis of (-)-Camphor.
Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential alpha-glucosidase inhibitors
A series of new benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides 12a-n as potential anti-alpha-glucosidase agents were designed and synthesized. alpha-Glucosidase inhibition assay demonstrated that all the synthesized compounds 12a-n (half-maximal inhibitory concentration [IC50] values in the range of 40.7 +/- 0.3-173.6 +/- 1.9 mu M) were more potent than standard inhibitor acarbose (IC50 = 750.0 +/- 12.5 mu M). Among them, the most potent compound was compound 12c, with inhibitory activity around 19-fold higher than acarbose. Since the most potent compound inhibited alpha-glucosidase in a competitive mode, a docking study of this compound was also performed into the active site of alpha-glucosidase. In vitro and in silico toxicity assays of the title compounds were also performed.
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