Related Products of 7411-23-6, A common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium hydrogen (423.17 mg) was added to a N,N-dimethylformamide solution (10 ml) of a compoundWX123-1 (2.0 g) at 0C, and the reaction was stirred for 0.5 hour at 0C. Isopropane iodide (1.57 g) was added to thereaction solution and the reaction was stirred at 25 C for 14 hours. After the reaction was completed, water (10 ml) wasadded to quench the reaction, and then water (20 ml) was added, and the solution was extracted with ethyl acetate (20ml) for three times. The mixed organic phase was washed with water (20 ml) twice, dried with anhydrous sodium sulfate,and then filtered and concentrated to obtain a crude product WX123-2. 1H NMR (400MHz, CHLOROFORM-d) delta = 3.88- 3.75 (m, 3H).
The synthetic route of 7411-23-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
1,2,3-Triazole – Wikipedia,
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