Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C2H2BrN3
5-Bromo-l-(4-methoxy-benzyl)-lH-[l,2 4]triazole In a 100 mL round-bottomed flask, 3-bromo-lH-l,2,4-triazole (3 g, 20.3 mmol, Eq: 1.00), 1- (chloromethyl)-4-methoxybenzene (3.18 g, 20.3 mmol, Eq: 1) and N-ethyl-N-isopropylpropan-2- amine (5.24 g, 40.6 mmol, Eq: 2) were combined with acetonitrile (101 ml) to give a light yellow solution. Potassium iodide (1.68 g, 10.1 mmol, Eq: 0.5) was added. The mixture was heated to reflux for 2 hours. The mixture was cooled down and poured into water (50 mL) and extracted with EtOAc (3×50 mL), the combined extracts were washed with water (50 mL) and brine (50 mL), dried over anhydrous Na2S04, concentrate to afford the crude product. Purify the compound by column chromatography (hexanes/ EtOAc = 70/30) to afford the oil 1.1 g (20percent).
According to the analysis of related databases, 7343-33-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics