3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C3H4N4O2
3-Amino-1 ,2,4-triazole-5-carboxylic acid hydrate (2.56 g, 0.02 mol) was dissolved in IMS (40 ml). Triethylamine (6 ml) was added and the solution was heated to 70C. After 10 minutes 4-cyanobenzaldehyde (2.62 g, 0.02 mol) and ethyl acetoacetate (2.60 g, 0.02 mol) were added and the reaction was heated at 70C for 24 hours. The mixture was filtered hot and allowed to cool. The volatiles were evaporated and the residue was partitioned between in ethyl acetate and 1 N HCI. A solid precipitated and was filtered off. The organic layer was separated, washed with water and then brine, dried (Na2S04), and evaporated. The residue was triturated with ethyl acetate. The solid material was combined with that which was collected earlier.Yield: 2.18 mg (31 %)LC-MS (Method 1 ): Rt = 2.69 min, m/z = 354 [M+H]+
The synthetic route of 3641-13-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED; EDWARDS, Christine; KULAGOWSKI, Janusz; FINCH, Harry; WO2011/110859; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics