Related Products of 74205-82-6, The chemical industry reduces the impact on the environment during synthesis 74205-82-6, name is (1H-1,2,4-Triazol-1-yl)methanol, I believe this compound will play a more active role in future production and life.
The indoline (1) (10.0 (^, 0.08311101) was added to a 11 round bottom flask, Glacial acetic acid 1001111, stirring at room temperature 0.5h, adding triazole methyl alcohol (16.61 g, 0.167 mol), and the reaction was stirred at 80 C for 3 h. TLC indicated that the reaction was complete and stopped The reaction was cooled to room temperature, 40% aqueous sodium hydroxide (100 ml) and 100 ml of methanol were added under ice-cooling, refluxed for 0.5 h at 70 C, Dichloromethane (75 mL x 3), saturated brine (150 ml x 2), dried over anhydrous sodium sulfate and concentrated to give Yellow oil 7.74 g (2), yield 46.6%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-1,2,4-Triazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sichuan University; Wu, Yong; Guan, mei; Zhao, yinbo; Hai, Li; He, Yi; Li, Xiao Cen; (9 pag.)CN103664901; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics