Application of 41253-21-8, These common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 46: Preparation of eis-4-amino-5-chIoro-N-[l-(3-(lH-l.,2,4-triazol-l- vDpropyr)-3-methoxypiperidin-4-v?-2-methoxybenzamideStep 1: Preparation of l-(3-chloropropyD-lH-l,2,4-triazole1 g of a 1 ,2,4-triazole sodium salt was dissolved in N,N-dimethylforrnamide, and the solution was cooled to 0C, to which 570 mg of 60% sodium hydride (NaH) was then added.The reactants were stirred for 20 min, and 1.3 mL of l-bromo-3-chloropropane was slowly added thereto. The reaction mixture was warmed to room temperature and stirred for 12 hours, followed by addition of water and extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to afford 600 mg (38%) of the title compound.1H NMR(CDCl3): delta 8.08(s, IH), 7.93(s, IH), 4.37-4.34(m, 2H), 3.47-3.43(m, 2H), and 2.35-2.29(m, 2H)
The synthetic route of 41253-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DONG-A PHARM. CO., LTD.; WO2008/114971; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics