Electric Literature of 27808-16-8,Some common heterocyclic compound, 27808-16-8, name is 4-Methyl-1H-1,2,3-triazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 5-chloro-6-methyl-pyrazolo [1,5-a] pyrimidine-3-carboxylic acid ethyl ester (400 mg), 4-methyl -1H-1, 2, 3-triazole (153 mg), potassium carbonate (277 mg) and N, N- dimethyl formamide (5 ml) stirring the mixture at room temperature overnight. The reaction mixture is poured into water at room temperature, the mixture and using ethyl acetate extraction. Organic layer using saturated salt water cleaning, in order to water-free magnesium sulfate drying, and the concentrated under reduced pressure. Aid hemostasis by silica gel column chromatography (ethyl acetate/hexane) purification in order to produce the title compound (106 mg).
The synthetic route of 27808-16-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKED A PHARMACEUTICAL COMPANY LIMITED; KAWASAKI, MASANORI; MIKAMI, SATOSHI; NAKAMURA, SHINJI; NEGORO, NOBUYUKI; IKEDA, SHUHEI; ASHIZAWA, TOMOKO; MARUI, SHOGO; TANIGUCHI, TAKAHIKO; (135 pag.)TW2016/520; (2016); A;,
1,2,3-Triazole – Wikipedia,
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