Reference of 288-36-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-36-8, name is 1H-1,2,3-Triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of 2bromo441uorobenzoic acid (30 g, 137 mmol), cesium carbonate (89.26 g, 274 rnmol) and Cul (5.27 g, 27,4 mmol) in DMF (200 mL) were added NN?dimeLhyicyelohexanei,2diamine (3.7 mL,23.3 mmoi) and 1Hi,2,3-triazoie (18.92 g, 274mmoi). The resulting mixture was stirred at 110 C overnight, cooled, concentrated in vacuo and diluted with water (150 rnL). The aqueous layer was extracted with EtOAc (300 mL x 3). The aqueous layer was acidified with 2N HCI and extracted with EtOAc (300 rnL x 4). The combined organic layers were washed with brine (150 mL x 3), dried over Na2SO4, filtered and the filtrate concentrated in vacuo, The residue was purifIed by chromatography on silica gel(petroleum ether: EtOAc = 100: 1 5 : 1) to provide the title compound as a solid. LRMS m/z (M+H) 208.0 found, 208.0 required.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics