Some common heterocyclic compound, 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one, molecular formula is C30H35N5O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
Add to a 50ml single-mouth bottle1-((2S,3S)-2-(Benzyloxy)-pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)- 1H-1,2,4-Triazole-5(4H)-one (1 g), 12 mol/L hydrochloric acid (5 ml) was stirred at 50 C.After 8 h, the dissolution was complete and TLC showed the reaction was complete.After cooling to room temperature, 6 mol/L NaOH (9 ml) was added, and NaHCO3 (10 ml) was evaporated, and water (10 ml) was added and stirred for 1 hour to form a solid. Filter by suction, wash the filter cake water (10ml),Recrystallization from isopropanol / toluene gave 0.7 g of a white solid, yield 85%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 184177-83-1, its application will become more common.
Reference:
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Shanghai Pharmaceutical Industry Institute; Huang Huoming; Lv Huimin; Xiao Zhichao; Cai Wei; Ren Zhongjie; Zhou Ting; Liu Zhenren; Zhou Weicheng; Zhang Haibo; (35 pag.)CN108341754; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics