Synthetic Route of 184177-83-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one, This compound has unique chemical properties. The synthetic route is as follows.
Into the 25ml reaction bottle1-((2S,3S)-2-(Benzyloxy)-3-pentyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H -1,2,4-triazole-5(4H)-one (0.30 g, 0.58 mmol),((3R,5S)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl P-toluenesulfonate (0.25 g, 0.53 mmol), stirred and dissolved, DMSO (3 ml) and 50% NaOH solution (0.11 g, 1.33 mmol), and stirred at room temperature for 4.0 h.10 ml of water was added dropwise, stirred for 0.5 h, filtered, washed with a small amount of water, and the crude product was directly subjected to a step reaction.
The chemical industry reduces the impact on the environment during synthesis 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Shanghai Pharmaceutical Industry Institute; Huang Huoming; Lv Huimin; Xiao Zhichao; Cai Wei; Ren Zhongjie; Zhou Ting; Liu Zhenren; Zhou Weicheng; Zhang Haibo; (35 pag.)CN108341754; (2018); A;,
1,2,3-Triazole – Wikipedia,
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