Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, Safety of 1H-[1,2,3]Triazole-4-carboxylic acid
To a stirred solution of 9-3 (2.Og, 3.6mMol), HOBT (0.5g, 3.9mMol), and 1H-1,2,3- triazole-4-carboxylic acid (0.4g, 3.9mMol) in anhydrous DMF (2OmL) was added DIEA (1.2mL, 7.2mMol) followed by EDC (0.76g, 3.9mMol). The solution was stirred at ambient temperature overnight. The solution was then treated with 2mL of acetic acid and was heated to 800C for 3hrs. Upon cooling to room temperature, the solution was filtered through a syringe filter and purified on a C18 reverse phase HPLC to give 9-4 as a solid. Mass (M+l) calculated: 631.2789 observed: 631.2778
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Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics