In 2022,Salinas-Torres, Angelica; Portilla, Jaime; Rojas, Hugo; Becerra, Diana; Castillo, Juan-Carlos published an article in Molbank. The title of the article was 《Synthesis, Spectroscopic Analysis, and In Vitro Anticancer Evaluation of 2-(Phenylsulfonyl)-2H-1,2,3-triazole》.Application of 288-36-8 The author mentioned the following in the article:
The 1,2,3-triazole derivatives containing the sulfonyl group have proved their biol. importance in medicinal chem. and drug design. In this sense, the regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole in good yield through a classical sulfonamidation reaction of 1H-1,2,3-triazole with benzenesulfonyl chloride in dichloromethane using a slight excess of triethylamine at 20° for 3 h is described. This procedure is distinguished by its short reaction time, high yield, excellent regioselectivity, clean reaction profile, and operational simplicity. The sulfonamide exhibited moderate activity against UO-31 renal, SNB-75 central nervous system, HCT-116 colon, and BT-549 breast cancer cell lines, with growth inhibition percentages (GI%) ranging from 10.83% to 17.64%. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics