Cyclization reactions in azole chemistry: the reaction of some azoles with o-fluoroacetophenone, o-fluorobenzaldehyde and o-fluorobenzophenone was written by Rosevear, Judi;Wilshire, John F. K.. And the article was included in Australian Journal of Chemistry in 1991.Recommanded Product: 2-(1H-1,2,4-Triazol-1-yl)benzaldehyde This article mentions the following:
The reactions of some azoles with o-fluoroacetophenone, o-fluorobenzaldehyde and o-fluorobenzophenone in DMSO solution in the presence of anhydrous K2CO3 have been investigated. In addition to the expected substitution products, cyclization reactions frequently occurred to give carbinols in the case of the reactions of o-fluoroacetophenone and o-fluorobenzophenone, and cyclic ketones in the case of the reactions with o-fluorobenzaldehyde. Thus, the reaction of o-FC6H4COMe with imidazole gave 30% imidazoindolol I at 130°, whereas o-FC6H4CHO and imidazole gave 20% imidazoindolone II. Fluoren-9-ol and related carbinols containing heteroaromatic nuclei are readily converted in DMSO solution into the corresponding ketones by treatment with anhydrous K2CO3. When treated with ethanolic alkali, 2-(benzimidazol-1-yl)acetophenone undergoes a remarkable transformation to give 1-(2-aminophenyl)quinolin-4(1H)-one. In the experiment, the researchers used many compounds, for example, 2-(1H-1,2,4-Triazol-1-yl)benzaldehyde (cas: 138479-53-5Recommanded Product: 2-(1H-1,2,4-Triazol-1-yl)benzaldehyde).
2-(1H-1,2,4-Triazol-1-yl)benzaldehyde (cas: 138479-53-5) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: 2-(1H-1,2,4-Triazol-1-yl)benzaldehyde
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics