((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRelated Products of 156311-83-0
Design of new small cyclic melanocortin receptor-binding peptides using molecular modeling: role of the His residue in the melanocortin peptide core was written by Prusis, Peteris;Muceniece, Ruta;Mutule, Ilze;Mutulis, Felikss;Wikberg, Jarl E. S.. And the article was included in European Journal of Medicinal Chemistry in 2001.Related Products of 156311-83-0 The following contents are mentioned in the article:
The conserved core, His-Phe-Arg-Trp, of melanocyte stimulating hormones (MSH) was probed by comparing a cyclic pentapeptide, cyclo(His-D-Phe-Arg-Trp-Gly), with three structurally similar cyclic peptides, cyclo(Asn-D-Phe-Arg-Trp-Gly), cyclo(D-Phe-Arg-Trp-Glu)-OH, and cyclo(D-Phe-Arg-Trp-Glu)-NH2, but lacking in His. All three peptides bound to the MC1, MC3, MC4 and MC5 receptors with similar affinities. Mol. modeling indicated that the 3D structure of the DPhe-Arg-Trp of all three peptides were closely similar. The data showed that the His residue of the small rigid cyclic MSH core peptides does not participate in binding with the melanocortin receptors. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Related Products of 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRelated Products of 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics