Triazoles

Liao, Jia-Ling published the artcileOs(II) Phosphors with Near-Infrared Emission Induced by Ligand-to-Ligand Charge Transfer Transition, Product Details of C8H5F3N4, the publication is Inorganic Chemistry (2014), 53(17), 9366-9374, database is CAplus and MEDLINE.

Heating of Os₃(CO)₁₂ with 6 equiv of 2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl) pyridine (fptzH) in refluxing diethylene glycol monomethyl ether, followed by sequential treatment with stoichiometric Me₃NO and addition of PPhMe₂, afforded two isomeric mixtures of red-emitting [Os(fptz)₂(PPhMe₂)₂] (1T and 1C), for which the notations T and C stand for the trans and cis-oriented fptz chelates, resp. Alternatively, preparation of Os(II) complex using a 1:1 mixture of 5,5′-di(trifluoromethyl)-3,3′-di-1,2,4-triazole (dttzH₂) and 2,2′-bipyridine (bpy), instead of fptzH, gave isolation of a mononuclear Os(II) complex [Os(bpy)(dttz)(CO)₂] (2) in moderate yield. Replacement of CO with PPhMe₂ on 2 afforded near-IR (NIR)-emitting Os(II) complex [Os(bpy)(dttz)(PPhMe₂)₂] (3). The single-crystal x-ray structural analyses were executed on 1C, 2, and 3 to reveal the structural influence imposed by the various chelates. The photophys. and electrochem. properties were measured and discussed using the results of d. functional theory (DFT) and time-dependent DFT calculations Complex 3 is selected as the dopant to probe its electroluminescent properties by fabrication of the NIR emitting organic light-emitting diodes.

Inorganic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Product Details of C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Yeh, Yu-Shan published the artcileA new family of homoleptic Ir(III) complexes: Tris-pyridyl azolate derivatives with dual phosphorescence, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is ChemPhysChem (2006), 7(11), 2294-2297, database is CAplus and MEDLINE.

The synthesis and characterization of a new family of homoleptic Ir(III) tris(pyridylazolate) complexes, in anticipation of seeing the symmetry restriction on such systems, i.e., showing efficient blue phosphorescence with better color chromaticity is reported. The synthetic scheme, from the isolated intermediate and x-ray analyses, rendered solely meridional structures. The results leads to propose an unusual intra-ligand charge transfer to ligand-to-ligand charge transfer conversion, i.e., an electron transfer like process (vide infra), for which the LLCT lowers the luminous efficiency and results in an unwanted bathochromatic shift.

ChemPhysChem published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C42H63O3P, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Chang, Chiung-Fang published the artcileHighly efficient blue-emitting iridium(III) carbene complexes and phosphorescent OLEDs, Synthetic Route of 219508-27-7, the publication is Angewandte Chemie, International Edition (2008), 47(24), 4542-4545, database is CAplus and MEDLINE.

Bright & blue: A strategy for reducing metal-chelate internal strain enables the preparation of blue emitting iridium(III) carbene complexes. The phosphorescent OLED fabricated from one of these complexes shows remarkable CIE coordinates of (0.16, 0.13) and peak efficiencies of 6.0% photons per electron, 6.3 cdA^-1, and 4.0 Im W^-1.

Angewandte Chemie, International Edition published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Synthetic Route of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Sheng, Chunquan published the artcileOptimization of the synthesis of the key intermediate of fluconazole by the orthogonal experimental design, COA of Formula: C12H13F2N3O4S, the publication is Zhongguo Yaowu Huaxue Zazhi (2002), 12(6), 344-346, database is CAplus.

Optimization of the preparation of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate, an intermediate in fluconazole synthesis, by reacting 2′,4′-difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone with trimethylsulfoxonium iodide was carried out using orthogonal exptl. design. The yield reached 62.34%.

Zhongguo Yaowu Huaxue Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C10H15ClO3S, COA of Formula: C12H13F2N3O4S.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Fang, Chung-Hong published the artcileIridium(I) pyridyl azolate complexes with saturated red metal-to-ligand charge transfer phosphorescence; fundamental and potential applications in organic light-emitting diodes, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Chemistry – A European Journal (2007), 13(9), 2686-2694, database is CAplus and MEDLINE.

Preparation of neutral metal complexes [(cod)Ir(fppz)] (fppz = 3-trifluoromethyl-5-(2-pyrdiyl)pyrazole, 1), [(cod)Ir(bppz)] (bppz = 3-tert-butyl-5-(2-pyridyl)pyrazole, 2), [(cod)Ir(fptz)] (fptz = 3-trifluoromethyl-5-(2-pyridyl)triazolate, 3) and [(cod)Ir(bptz)] (bptz = 3-tert-butyl-5-(2-pyridyl)triazolate, 4), bearing one cod ligand and a pyridyl azolate chelate are reported. A single-crystal x-ray diffraction study of 3 reveals the expected distorted square-planar geometry. The lowest absorption band consists of Ir^I atom increased triplet d_π → π^* transitions (³MLCT), the assignment of which is firmly supported by the theor. approaches. Complexes 1–4 exhibit weak phosphorescence in degassed solution at room temperature, whereas much more intense, solid-state phosphorescence appears in the range 622-649 nm. The pure MLCT emission was used as a prototypical model to address its remarkable spectral differences from the Ir^III isoquinoline pyrrolide complex (5), which has mainly ³ππ phosphorescence. Complex 3 was used as a dopant to fabricate red-emitting phosphorescent organic light-emitting diodes (OLEDs). For the 7% doped device, a maximum brightness of 3010 cd m^-2 was achieved at an applied voltage of 15 V and with CIE coordinates of (0.56, 0.33), demonstrating for the 1st time the potential of neutral Ir^I complexes in OLED applications.

Chemistry – A European Journal published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Wang, Shu-dong published the artcileSynthesis and antifungal activity of the novel triazole compounds, SDS of cas: 86386-77-8, the publication is Yaoxue Shijian Zazhi (2011), 29(6), 426-430, database is CAplus.

To design, synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole, the big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and ¹H NMR, et al. Eighteen triazole compounds I(R = 2-F, 3-F, 4-F, 2-Cl, 3-Cl, 4-Cl, 2-Br, 3-Br, 2-Me, 3-Me, 4-Me, 2-NO₂, 3-NO₂, 4-NO₂, 2-CN, 3-CN, 4-CN, H) were synthesized and the antifungal activity were also evaluated against the eight common pathogenic fungi. The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.

Yaoxue Shijian Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C20H19NO4, SDS of cas: 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Ren, Xiao-hui published the artcileSynthesis, crystal structures and antifungal activity of novel triazole compounds containing 1,3-dioxolane, Application In Synthesis of 86386-77-8, the publication is Yaoxue Shijian Zazhi (2012), 30(5), 344-347, database is CAplus.

To synthesize the geometric isomer of (E)-1-((4-(2,4-difluorophenyl)-2-(4-fluorostyryl)-1,3-dioxolan-4-yl)methyl)-1H-l,2,4-triazole, determine their structures by XRD and evaluate their antifungal activities in vitro, the target compounds were prepared from 1H-1,2,4-triazole and 2-chloro-2′,4′-difluoroacetophenone, the key oxirane intermediate was obtained by Corey-Chaykovsky epoxidation The key oxirane intermediate was hydrolyzed in the presence of 9% sulfuric acid, then the product was reacted with 4-fluorinecinnamaldehyde by condensation reaction to afford 6Ka and 6Kb. Their structures were characterized by ^-1H NMR, MS and XRD. Compound 6Ka belonged to monoclinic crystal system, space group P2(1)/c and had a cis configuration. While compound 6Kb belonged to monoclinic crystal system, space group P2(1)/n and had a trans configuration. Both compounds which showed strong antifungal activities in vitro against five fungi. The antifungal activities of compound 6Kb was better than that of 6Ka. The trans configuration of this kind had a predominant in vitro antifungal activities than the corresponding cis configuration.

Yaoxue Shijian Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Application In Synthesis of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Zhu, Tianbao published the artcileLanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections, Quality Control of 86386-77-8, the publication is European Journal of Medicinal Chemistry (2021), 113524, database is CAplus and MEDLINE.

Invasive fungal infections remain a challenge due to lack of effective antifungal agents and serious drug resistance. Discovery of antifungal agents with novel antifungal mechanism is important and urgent. Previously, we designed the first CYP51/HDAC dual inhibitors with potent activity against resistant Candida albicans infections. To better understand the antifungal spectrum and synergistic mechanism, herein new CYP51/HDAC dual inhibitors were designed which showed potent in vitro and in vivo antifungal activity against C. neoformans and C. tropicalis infections. Antifungal mechanism studies revealed that the CYP51/HDAC dual inhibitors acted by inhibiting various virulence factors of C. tropicalis and C. neoformans and down-regulating resistance-associated genes. This study highlights the potential of CYP51/HDAC dual inhibitors as a promising strategy for the discovery of novel broad-spectrum antifungal agents.

European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C7H8FNO2S, Quality Control of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Du, Juan-juan published the artcileCurrent nondopaminergic therapeutic options for motor symptoms of Parkinson′s disease, Safety of 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, the publication is Chinese Medical Journal (Beijing, China, English Edition) (2017), 130(15), 1856-1866, database is CAplus and MEDLINE.

The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson′s disease (PD). Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between Jan. 1988 and Nov. 2016 were searched using the following keywords: PD, nondopaminergic therapy, adenosine, glutamatergic, adrenergic, serotoninergic, histaminic, and iron chelator. We also reviewed the ongoing clin. trials in the website of clinicaltrials.gov. Articles related to the nondopaminergic treatment of motor symptoms in PD were selected for this review. PD is conventionally treated with dopamine replacement strategies, which are effective in the early stages of PD. Long-term use of levodopa could result in motor complications. Recent studies revealed that nondopaminergic systems such as adenosine, glutamatergic, adrenergic, serotoninergic, histaminic, and iron chelator pathways could include potential therapeutic targets for motor symptoms, including motor fluctuations, levodopa-induced dyskinesia, and gait disorders. Some nondopaminergic drugs, such as istradefylline and amantadine, are currently used clin., while most such drugs are in preclin. testing stages. Transitioning of these agents into clin. beneficial strategies requires reliable evaluation since several agents have failed to show consistent results despite pos. findings at the preclin. level. Targeting nondopaminergic transmission could improve some motor symptoms in PD, especially the discomfort of dyskinesia. Although nondopaminergic treatments show great potential in PD treatment as an adjunct therapy to levodopa, further investigation is required to ensure their success.

Chinese Medical Journal (Beijing, China, English Edition) published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C25H29N9O3, Safety of 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Li, Xiaohong published the artcileDensity Functional Theory Study of Several Nitrotriazole Derivatives, SDS of cas: 84406-63-3, the publication is Journal of Energetic Materials (2010), 28(4), 251-272, database is CAplus.

Quantum chem. calculations at B3LYP/6-31G* and B3P86/6-31G* levels are used to predict the bond dissociation energies (BDEs) of seven nitrotriazole derivatives It is noted that the BDEs of the initial scission step are between 44 and 70 kcal/mol, which are larger than those of piperidine and diazocine compounds and polynitro benzoate mols. In addition, substituent groups greatly affect the bond dissociation energies of the title compounds The heats of formation (HOFs) for seven energetic materials are also calculated via designed isodesmic reactions. From computational results it is noted that substituent groups strongly affect the HOFs. The research demonstrated that the HOF of the compound substituted by a five-membered ring is larger than those substituted by a six-membered ring for 1,2,4-triazole. The detonation performance data of the title compounds are also calculated according to the HOFs calculated by B3LYP/6-31G* level.

Journal of Energetic Materials published new progress about 84406-63-3. 84406-63-3 belongs to triazoles, auxiliary class Triazole,Nitro Compound, name is 4-Nitro-2H-1,2,3-triazole, and the molecular formula is C2H2N4O2, SDS of cas: 84406-63-3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics