Triazoles

Reference of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

3,5-Diamino-1,2,4-triazole (151.7 mg, 1.5 mmol) in ethanol(10 mL) was added to a solution containing 2-hydroxy-1-naphthalehyde (298.7 mg, 1.7 mmol) in ethanol (10 mL).The reaction mixture was stirred for 1 d, until the yellow precipitate appeared. The precipitate was filtered and washed with ether (10 mL¡Á2) and ethanol (10 mL). The yield was 69 percent (262.1 mg). 1H NMR (400 MHz, DMSO-d6, ppm) delta12.13 (s, 1H), 9.84 (s, 1H), 8.21 (d, J=8.7 Hz, 1H), 8.00 (d,J=9.2 Hz, 1H), 7.87 (d, J=8.1 Hz, 1H), 7.60 (t, J=7.7 Hz,1H), 7.41 (t, J=7.5 Hz, 1H), 7.13 (d, J=9.1 Hz, 1H), 6.30 (s,2H); 13C NMR (100 MHz, DMSO-d6, ppm): 166.36 (1C),160.37 (1C), 157.71 (1C), 157.30 (1C), 136.61 (1C), 133.02(1C), 129.66 (1C), 128.89 (1C), 127.64 (1C), 124.18 (1C),120.89 (1C), 120.03 (1C), 108.95 (1C). LRMS (ESI): m/zcalcd for C13H10N5O: 252.089 ([M-H+]); found, 252.267.Anal. calcd for C13H11N5O (249.273): C, 61.65; H, 4.38; N,27.65; found: C, 61.75; H, 4.39; N, 27.93.

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Lee, Jae Jun; Lee, Sun Young; Bok, Kwon Hee; Kim, Cheal; Journal of Fluorescence; vol. 25; 5; (2015); p. 1449 – 1459;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, Recommanded Product: 16681-70-2

lH-l,2,3-triazole-4-carboxylic acid (24.6 mg, 217 muiotaetaomicron) was combined with HATU (83 mg, 217 muiotaetaomicron) in DMF (0.3 mL) and stirred at room temperature for 15 minutes. Compound 2 (89 mg, 197 muiotaetaomicron) and DIPEA (103 mu, 592 muiotaetaomicron) were then added. The resulting solution was stirred at room temperature for 15 minutes; LC/MS showed the mass of the desired product. The solvent was removed in vacuo and the crude residue was dissolved in EtOH (3.0 mL). A solution of IN LiOH in water (1.6 mL, 1.6 mmol) was added, and the mixture was stirred overnight at 40C. LC/MS showed the mass of the desired product. The solvent was removed in vacuo and the crude residue was purified by preparative HPLC to yield the title compound (5 mg) as a TFA salt. MS m/z [M+H]+ calc’d for C25H29CIFN5O4, 518.19; found 518.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 15988-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15988-11-1, name is 4-Phenyl-1,2,4-triazolidine-3,5-dione belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Dimedone (0.14 g, 1 mmol), benzaldehyde (0.1 g, 1 mmol), and 4-phenylurazole (0.177 g, 1 mmol) were mixed with PEG-SO3H (0.6 g, 0.1 mmol) and the obtained mixture was stirred magnetically at 80 C for 40 min. After the completion of the reaction warm water (20 mL) was added and the mixture stirred for about 5 min. The insoluble crude product was filtered and recrystallized from EtOH/H2O 4:1 and the pure product was obtained (0.352 g, 91%). In order to recover the catalyst, the filtrate was dried under reduced pressure and recovered catalyst was washed with diethyl ether and reused after drying under reduced pressure. The equivalent procedure was used for the synthesis of triazolo[1,2-a]indazole-tetraones.

The synthetic route of 4-Phenyl-1,2,4-triazolidine-3,5-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hasaninejad, Alireza; Zare, Abdolkarim; Shekouhy, Mohsen; Tetrahedron; vol. 67; 2; (2011); p. 390 – 400;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, A new synthetic method of this compound is introduced below., Recommanded Product: 7411-23-6

To a sol. of 3,5-dibromo-lH-l,2,4-triazole (60 g, 264.48 mmol) in CH3CN (600 mL) were added 2-(2-bromoethoxy)tetrahydro-2H-pyran (48.01 mL, 317.38 mmol) and DIPEA (48.08 mL, 290.93 mmol). The r.m. was stirred at 90 C for 3 h. The mixture was then diluted with EtOAc and washed with a sat. aq. NaHC03 sol. and brine. The separated o.l. was dried (MgS04), filtered and the solvent evaporated in vacuo. The crude product was purified by flash column chromatography (silica; eluent: DCM/(7 N NH3 in MeOH) from 100/0 to 97/3). The product fractions were collected and the solvent evaporated in vacuo. Yield: 72 g of intermediate 45 (77% yield).

The synthetic route of 7411-23-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICALS, INC.; MINNE, Garrett, Berlond; BISCHOFF, Francois Paul; GIJSEN, Henricus, Jacobus, Maria; VELTER, Adriana, Ingrid; PIETERS, Serge, Maria, Aloysius; BERTHELOT, Didier, Jean-Claude; WO2013/10904; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 584-13-4, These common heterocyclic compound, 584-13-4, name is 4H-1,2,4-Triazol-4-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(4F-l,2,4-Triazol-4-yamino)-2-broraobenzonitriIe (CAB05094)To a solution of 4H-l,2,4-triazol-4-amine (4 204 gt 50,0 mmol) in DMSO (50 mL) was added KOtBu (5.51 g, 50,0 mmol). The mixture was stirred for 0,5 hours at room temperature before 4-fluoro-2-bromobenzonitrile (5.00 g, 25,0 mmol) was added and stirring was continued for 1 hour. The mixture was poured into crushed ice and neutralized with 2M KHSO4 solution. The precipitate was filtered off and recrystallised from MeOH to give CAB05094 (4.82 g, 73%) as a light yellow crystalline solid. Mp 234-236 0C; 1H NMR (400 MHz5 DMSO^6) delta 6,66 (dd, J= 8,6, 2.4 Hz, IH), 6,79 (d, J= 2,4 Hz, IH)5 7,78 (d, J- 8.6 Hz, IH), 8.86 (s, 2H)5 10.45 (s, IH); 13C NMR (100.6 MHz3 DMSO-rf6) delta 105.0, 1 11.5, 115.4, 117.8, 126.0, 136.2, 143,9, 151.8; LRMS (APCI-): m/z 226611,,88 ((110000%%,, [[CC99HH557799BBrrNN55]]””)),, 226633..88 ((9900%%,, [[CC59H581BiN5]”); HRMS (ES+) calcd for C9H779BrN5 [M+H]+: 263,9879, found 263.9870;

Statistics shows that 4H-1,2,4-Triazol-4-amine is playing an increasingly important role. we look forward to future research findings about 584-13-4.

Reference:
Patent; STERIX LIMITED; WOO, Lok Wai Lawrence; BUBERT, Christian; WOOD, Paul Michael; PUTEY, Aurelien; PUROHIT, Atul; POTTER, Barry Victor Lloyd; WO2011/23989; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows., category: Triazoles

5-Methyl-2- (2H-1,2,3-triazol-2-yl) benzoic acid (2.03 g, 10 mmol) was added to a 100 mL single neck round bottom flask,Dissolved with anhydrous dichloromethane (20 mL)Thionyl chloride (15 mL, 200 mmol) and pyridine (0.15 mL, 2 mmol) were then added slowly,Gradually warmed to reflux for 3 hours.The reaction was stopped, cooled and the solvent was slowly evaporated under reduced pressure. The resulting product was used directly in the next step.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 956317-36-5.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Xu Juan; Zhong Wenhe; Zhang Yingjun; Liu Qi; (35 pag.)CN105949203; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 7411-23-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7411-23-6 as follows.

A mixture of salt 1a (1 g, 2.9 mmol), 3,5-dibromo-1,2,4-triazole (0.66 g, 2.9 mmol), and K2CO3 (1.20 g, 8.7 mmol) in DMF (10 ml) was refluxed for 2 h. The mixture was cooled and poured into water (50 ml). The precipitate formed was filtered off and recrystallized from DMF. Yield 0.56 g (64%), colorless crystals; mp 244-246 C. IR spectrum, nu, cm-1: 3078, 3059, 3040 (H arom), 2932 (H2), 1628, 1558, 1531, 1512, 1466, 1439, 1404, 1292, 1265, 1215, 1173, 1157, 1142, 1068, 987, 972, 818, 768, 748, 717. 1H NMR spectrum (DMSO-d6), delta, ppm: 5.61 (2H, s, CH2); 7.35 (1, d, J = 9.2, H Ar); 7.51 (1, dd, J = 8.2, J = 0.9, H Ar); 7.61 (1, dd, J = 8.2, J = 1.4, H Ar); 7.76 (1H, d, J = 8.2, H Ar); 7.90-7.93 (2, m, H Ar). 13C NMR spectrum (DMSO-d6), delta, ppm: 45.1 (CH2); 108.5 (C); 117.1 (CH); 122.8 (CH); 126.3 (CH); 128.3 (CH); 128.9 (CH); 129.8 (C); 130.7 (CH); 130.8 (C); 137.5 (C); 145.4 (C); 153.37 (C). Found, %: 51.78; 2.57; N 14.03. C13H8BrN3O. Calculated, %: C 51.68; H 2.67; N 13.91.

According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Osyanin; Osipov; Klimochkin, Yu. N.; Chemistry of Heterocyclic Compounds; vol. 47; 12; (2012); p. 1607 – 1609; Khim. Geterotsikl. Soedin.; vol. 47; 12; (2011); p. 1914 – 1916,3;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1455-77-2,Some common heterocyclic compound, 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of Hdatrz (9.9mg, 0.1mmol), NO2-H2ip (21.1mg, 0.1mmol) and Co(NO3)2¡¤6H2O (14.5mg, 0.05mmol) was dissolved in doubly distilled water (15.0mL), and the initial pH of the reactant mixture was adjusted to ca. 6 by slow addition of triethylamine with constant stirring. The resulting mixture was then transferred into a Teflon-lined stainless steel vessel (23.0mL) and heated at 140¡ãC for 72h under autogenous pressure. After the mixture was cooled to room temperature at a rate of 3.2¡ãCh?1, pink block-shaped crystals suitable for X-ray analysis were obtained directly, washed with water and dried in air (Yield: 50percent, based on CoII salt). Anal. Calc. for C20H18Co2N12O14: C, 31.27; H, 2.36; N, 21.88. Found: C, 31.25; H, 2.37; N, 21.86percent. IR (KBr pellet, cm?1): 3422 (br), 3336 (w), 3270 (w), 3083 (w), 1620 (s), 1571 (s), 1533 (s), 1366 (s), 1348 (s), 1200 (w), 1102 (w), 1068 (w), 822 (w), 785 (w), 753 (w), 735 (m), 718 (s), 669 (w), 563 (w), 525 (w), 477 (w), 433 (w).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diamino-1,2,4-triazole, its application will become more common.

Reference:
Article; Zhao, Hong; Li, Hong-Xue; Liu, Zhong-Yi; Yang, En-Cui; Zhao, Xiao-Jun; Polyhedron; vol. 101; (2015); p. 29 – 36;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 16681-65-5,Some common heterocyclic compound, 16681-65-5, name is 1-Methyl-1H-1,2,3-triazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 39(2,4-dichloro-3-phenylquinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanolTo a flask containing 1 -methyl- lH-l ,2,3-triazole (125 mg, 1.5 mmol) was added THF (10 mL) and the colorless solution was cooled to -45 C. Then, -BuLi (2.5 M in hexaiies, 0,6 mL, 1.5 mmol) was added affordi g a suspension. The suspension was stirred between -40 C and -10 C for 30 minutes, then a THF solution of (2,4-dichloro-3-phenylquinolin-6-yl)(l,2-dimethyl-lH- imidazol-5-yl)niethanone (500 mg, 1.26 mmol, Intermediate 18: step b, in 5 mL THF) was introduced and the mixture was allowed to warm up to room temperature. After 1 hour, the reaction mixture was heated to 40 C for 3 hours and then quenched with aqueous NH4CI solution. The aqueous portion was extracted with EtOAc (3 x 50 mL) and then with DCM (3 x 50 mL). The individual organic portions were washed with brine, dried over MgS04, filtered, combined and concentrated to dryness. Chromatography on silica gel (5% MeOH-DCM increasing to 10% MeOH) provided material which was re -purified by preparative TLC (5% 2 M-NH3-MeOH-EtO Ac) to provide the title compound as light tan solid. H NMR (500 MHz,CDCI3) delta 8.45 – 8.36 (m, 1H), 7.94 (d, J= 8.8 Hz, IH), 7.66 – 7.46 (m, 4H), 7.46 – 7.30 (m, 2H), 7.01 (s, 1H), 5.94 (s, IH), 3.91 (s, 3H), 3.34 (s, 3H), 2.17 (s, 3H). MS (ESI): mass calcd. for C24H20CI2N6O, 478.1 , m/z found 479.1 [M+H]+.

The synthetic route of 16681-65-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, Kent; EDWARDS, James, P.; KREUTTER, Kevin, D.; KUMMER, David, A.; MAHAROOF, Umar; NISHIMURA, Rachel; URBANSKI, Maud; VENKATESAN, Hariharan; WANG, Aihua; WOLIN, Ronald, L.; WOODS, Craig, R.; FOURIE, Anne; XUE, Xiaohua; CUMMINGS, Maxwell, D.; LEONARD, Kristi, A.; WO2015/57203; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 16681-70-2,Some common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0814] lH-1,2,3-triazole-5-carboxylic acid (3.4 mg, 30f.tmol) was combined with HATU (11 mg, 30 f.tmol) in DMF(0.3 mL) and stirred at room temperature for 10 minutes;DIPEA (1 eq.) was added and the mixture was stirred for 1minute. Compound 2 (1 0 mg, 30 f.tmol) was dissolved in DMF(0.5 mL) and DIPEA (5.2 f.LL, 30 fllllOI) was added, followedby addition of the activated acid solution. The mixture wasstirred at room temperature for 30 minutes, after which timeLCMS indicated desired product formation. Half of the crudeproduct was purified using reverse phase chromatography toyield Compound a (20 mg) as a TFA salt. MS m/z [M+Hrcalc’d for C27H31CIFN50 4 , 544.21; found 544. Half of thecrude product was used in the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-[1,2,3]Triazole-4-carboxylic acid, its application will become more common.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics