Triazoles

Electric Literature of 41253-21-8,Some common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Chloro-N-(6-alkoxybenzo[d]thiazol-2-yl)acetamide (5 mmol) and sodium 1,2,4-triazole (6 mmol)were dissolved in N,N-dimethylformamide (10 mL) and stirred for 10 h at room temperature. Half of thesolvent was then evaporated, the solution was poured in 50 mL water, and extracted with ethyl acetate(30 mL 3). The ethyl acetate layer was dried over anhydrous MgSO4. After removing the solventunder reduced pressure, the crude product was obtained and recrystallized from dichloromethane toyield a white solid. N-(6-((3-Fluorobenzyl)oxy)benzo[d]thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)acetamide (7a). White solid in55.1%. mp: 212-213 C. 1H-NMR (300 MHz, DMSO) delta12.73 (s, 1H, -CO-NH-), 8.59 (s, 1H, triazole-H),8.03 (s, 1H, triazole-H), 7.77-7.64 (m, 2H, Ar-H), 7.52-7.40 (m, 1H, Ar-H), 7.37-7.27 (m, 2H, Ar-H),7.23-7.10 (m, 2H, Ar-H), 5.33 (s, 2H, triazole -CH2-), 5.18 (s, 2H, -OCH2-). 13C-NMR (75 MHz, DMSO) delta166.31, 162.67 (d, J = 243.8 Hz), 156.09, 155.57, 152.04, 146.23, 142.99, 140.38 (d, J = 7.5 Hz), 133.21,130.94 (d, J = 8.4 Hz), 124.07 (d, J = 2.6 Hz), 121.88, 116.15, 115.08 (d, J = 21.0 Hz), 114.77 (d, J = 21.8 Hz),106.59, 69.42, 51.57. IR (KBr) cm1: 1605.72, 1556.78 (C=N). Tof-MS: m/z [M + H]+ 383.65.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Sodium 1,2,4-triazol-1-ide, its application will become more common.

Reference:
Article; Liu, Da-Chuan; Zhang, Hong-Jian; Jin, Chun-Mei; Quan, Zhe-Shan; Molecules; vol. 21; 3; (2016);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 135242-93-2, name is (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 135242-93-2, Product Details of 135242-93-2

A mixture of carbonyldiimidazole (CDI, 4.62 g, 28.5 mmol), ( 1 -methyl- 1,2, 4-triazol- 3-yl)methanol (3.45g, 30.53 mmol), and 2-MeTHF (50 mL) was stirred at room temperature (20 C) for 3 hours. To the mixture was added methyl (5)-l-amino-7-fluoro-2,3-dihydro-lH- indene-4-carboxylate hydrochloride [lOa.HCl] (5.0 g, 20.35 mmol) followed by N,N- diisopropylethylamine (6.58 g, 50.9 mmol). The contents were heated to 60 C and stirred for 15 hours. The mixture was cooled to 20 C, charged with water (50 mL), and stirred for 30 min. The slurry was filtered, washed with 2-MeTHF (2 x 5 mL) and dried under vacuum to give methyl fV)-7-riuoro- 1 -(((( 1 -methyl- 1 H- 1.2.4-triazol-3-yl)methoy)carbonyl)amino)- 2,3-dihydro-lH-indene-4-carboxylate [11a] as white crystalline solid (5.8g, 81.8% yield). ‘H NMR (400 MHz, DMSO-d6) d 8.41 (s, 1H), 7.87 (dd, J = 8.6, 5.0 Hz, 1H), 7.78 (d, J = 8.7 Hz, 1H), 7.11 (t, J = 8.8 Hz, 1H), 5.28-5.22 (m, 1H), 4.98 (q, J = 10 Hz, 2H), 3.82 (s, 3H), 3.80 (s, 3H), 3.31 (ddd, J = 17.6, 8.8, 5.5 Hz, 1H), 3.06 (ddd, J = 17.6, 8.7, 6.3 Hz, 1H), 2.44- 2.35 (m, 1H), 1.94-1.81 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1-Methyl-1H-[1,2,4]triazol-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; COLE, Andrew G.; KULTGEN, Steven; PAMULAPATI, Ganapati Reddy; SPINK, Jan Michelle; (76 pag.)WO2019/200114; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 3641-08-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3641-08-5, name is 2H-1,2,4-Triazole-3-carboxamide belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

In a 500 ml jacketed flask equipped with a mechanical stirrer, a temp probe, a circulation bath and a positive nitrogen atmosphere set up was placed with 1,2,4-triazole-3-carboxamide 25.3 gm (0.112 mole), 1,4-dioxane 225 gm, and pyridine 72.8 gm (0.92 mole). The mixture was chilled to -6.8 C. Trifluoroacetic anhydride 107.1 gm (0.51 mole) was added dropwise at -1.3 to -6.8 C. in 10 min. Then the mixture was warmed to ambient temperature and stirred for 30 min. Without work up, a sample was taken for HPLC analysis. The chromatogram showed that the product contained 93% 3-CNT and 0.2% 3-CAT.

The synthetic route of 2H-1,2,4-Triazole-3-carboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ampac Fine Chemicals LLC; US2009/292122; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 7170-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of compound 10 (500 mg, 1.03 mmol), 4-methylpyridin-2-ol (168 mg, 1.54 mmol) and K2CO3(283 mg, 2.05 mmol) in DMF (5 mL) was stirred at 80 oC for 10 hoursand then concentrated in vacuo to remove DMF. The residue was diluted withwater and extracted with EtOAc. The organic layer was washed with brine, driedover Na2SO4, filtered and concentrated in vacuo. Theresidue was purified by column chromatography (PE : EtOAc = 1 : 1) to give theproduct of 1r (400 mg, yield: 83%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; He, Shuwen; Li, Peng; Dai, Xing; McComas, Casey C.; Du, Chunyan; Wang, Ping; Lai, Zhong; Liu, Hong; Yin, Jingjun; Bulger, Paul G.; Dang, Qun; Xiao, Dong; Zorn, Nicolas; Peng, Xuanjia; Nargund, Ravi P.; Palani, Anandan; Tetrahedron Letters; vol. 55; 14; (2014); p. 2212 – 2216;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Amino-4H-1,2,4-triazole-3-carboxylic acid

General procedure: A mixture of benzil (0.01 mol), aldehydes (0.01 mol), 3-amino-1,2,4-triazole-5-carboxylic acid (0.01 mol), ammonium acetate (0.01 mol) and ceric ammonium nitrate (15 mol%) as a catalyst were refluxed in ethanol (15 mL) for about 3-4 h. The progress of the reaction was monitored by TLC. After completion of reaction, the mixture was cooled to room temperature. The solid formed was filtered and dried. The crude products were recrystallized by ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3641-13-2, its application will become more common.

Reference:
Article; Nikalje, Anna Pratima G.; Ghodke, Mangesh S.; Kalam Khan, Firoz A.; Sangshetti, Jaiprakash N.; Chinese Chemical Letters; vol. 26; 1; (2015); p. 108 – 112;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 16681-70-2

[0614] 1H-1,2,3-triazole-5-carboxylic acid (3.4 mg, 30f.tmol) was combined with HATU (11 mg, 30 f.tmol) in DMF(0.3 mL) and stirred at room temperature for 10 minutes;DIPEA (1 eq.) was added and the mixture was stirred for 1minute. Compound 5 (9 mg, 30 fllllOI) was dissolved in DMF(0.5 mL) and DIPEA (5.2 f.LL, 30 fllllOI) was added, followedby addition of the activated acid solution. The mixture wasstirred at room temperature for 30 minutes, after which timeLCMS indicated desired product formation. Half of the crudeproduct was purified using reverse phase chromatography toyield the title compound c as a TFA salt (1 mg). MS m/z[M+Hr calc’d for C25H29CIFN50 4 , 518.19. found 518.

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 342617-08-7, name is 3-(3-Bromophenyl)-4H-1,2,4-triazole, A new synthetic method of this compound is introduced below., category: Triazoles

EXAMPLE 11 A mixture of 2.67 g of oxamohydrazide, 4.05 g of formamidine acetate and 30 ml of formamide was heated for reaction at 72 to 74 C. for 1.5 hours. After reaction, the resulting reaction mixture was cooled to room temperature and then filtered. The thus obtained crystal was washed with 10 ml of 2-propanol and then added to a mixture of 20 ml of conc. aqueous ammonia and 80 ml of water. The resulting reaction mixture was stirred at room temperature for 10 minutes and then filtered to obtain 0.22 g of oxamide as a crystal. The filtrate was concentrated under reduced pressure to obtain 2.01 g (69%) of 1,2,4-triazole-3-carboxamide as a crystal.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ube Industries, Ltd.; US4578479; (1986); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 584-13-4, These common heterocyclic compound, 584-13-4, name is 4H-1,2,4-Triazol-4-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 0.033 mol of 4-amino-1,2,4-triazole to 60 mL of water.0.035 mol sodium carbonate, stirred for 10 min in an ice bath,Cyanuric chloride solution was added dropwise in 10 min,Stir at 100 C for 10 hours, cool to room temperature, and filter by suction.Washing three times with water at 5 C, drying at 70 C, to obtain a s-triazine-based fluorescent probe, yield 95%;The cyanuric chloride solution,Are 0.01 mol of cyanuric chloride in 30 mL of 1,4-dioxane mixed solution was obtained.

The synthetic route of 584-13-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; University of Jinan; Wang Zhiling; Kuang Xuan; Cui Yu; Sun Xu; Zhang Yong; (7 pag.)CN108047210; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 7411-23-6

General procedure: The prepared grades of R-Ni were weighed in water after considering its specific gravity. The residual water was removed using dean stark apparatus. (0043) All the reactions were carried out in a 2-neck round bottom flask, attached with a condenser. Typically, reaction was carried out by stirring and refluxing the reaction mixture of amine and alcohol with pretreated R-Ni in 20ml solvent. After reaction completion, reaction mixture was cooled and filtered using Whatman filter paper 40. The solvent was removed in vacuo. The mixture thus obtained was purified using column chromatography. The purified compounds obtained were characterized by IR, NMR, LC-MS and melting or boiling point. The analytical data obtained of the known compounds are in agreement to the reported literature.

According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mehta, Astha; Thaker; Londhe; Nandan, Santosh R.; Applied Catalysis A: General; vol. 478; (2014); p. 241 – 251;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 178928-70-6,Some common heterocyclic compound, 178928-70-6, name is 2-(2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazole-3(2H)-thione, molecular formula is C14H15Cl2N3OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.1 Weigh 50 mg of the compound of formula I into a 10 mL sample vial, dissolve in 1.0 mL of diethylamine at room temperature and shake slightly until it is clear. When 5.0 mL of n-heptane was added dropwise, the solution appeared white turbid. After standing for 24 hours, light brown lump single crystals precipitated at the bottom of the bottle, and the color was darker. Filter out part of the single crystal, put it in a vacuum oven and dry for 6h, then the diethylamine solvate of the present invention can be obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazole-3(2H)-thione, its application will become more common.

Reference:
Patent; East China University of Science and Technology; Li Zhong; Ren Guobin; Xu Xiaoyong; Hong Minghuang; Gong Chengyu; Hu Jian; (17 pag.)CN110272393; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics