Triazoles

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6818-99-1, name is 3-Chloro-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C2H2ClN3

2- [6-Chloro-3- (ethanesulfonyl) pyridin-2-yl] -3-methyl-6- (pentafluoroethyl)-3H-imidazo [4,5-b] 300mg, sodium hydride (60 %, in a mixture of oil) 45mg and DMF 1.3mL, was added under ice-cooling 3-chloro-1H-1,2,4-triazole 116mg. The reaction mixture was stirred under ice cooling for 20 hours, water was added to the reaction mixture, followed by extraction with ethyl acetate. The resulting organic layer was dried over anhydrous sodium sulfate, and then dried under reduced pressure. The resulting residue was subjected to silica gel chromatography, the compounds of the present invention beta33 referred to below was obtained 240mg.

The synthetic route of 6818-99-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NAKAJIMA, YUJI; OKAWARA, YUICHI; (263 pag.)JP2016/102104; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

Step 2: (2-(2H-l ,2,3-triazol-2-yl)phenyl)((2i?,56 -5-hvdroxy-2-methylpiperidin-l-yl)methanone (3) A solution of (3S, 6i?)-6-methylpiperidin-3-ol (3.46 g, 30.0 mmol), 2-(2H- 1,2,3- triazol-2-yl)benzoic acid (6.82 g, 36.0 mmol), EDC (11.52 g, 60.1 mmol), l-hydroxy-7- azabenzotriazole (8.18 g, 60.1 mmol), and triethylamine (12.6 mL, 90 mmol) in DMF (200 mL) was stirred at 50 C overnight, then diluted with saturated aqueous sodium bicarbonate and extracted 3x with ethyl acetate. The organics were washed with brine, dried over magnesium sulfate, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-100% ethyl acetate in hexanes), providing the titled compound as a yellow-white solid. LRMS m/z (Mu+Eta) 287.3 found, 287.1 required.

The synthetic route of 1001401-62-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2015/88865; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 1455-77-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2-Naphthalenesulfonyl chloride (60 mmol, 13.5 g) was slowlyadded to a solution containing 5-amino-1,2,4-triazole (60 mmol,5.04 g) (for anstrz synthesis) or 3,5-diamino-1,2,4-triazole (60 mmol,5.95 g) (for danstrz synthesis) and pyridine (60 mmol, rho = 0.978 g/mL,4.85 mL) in 100 mL of acetonitrile (dry) under a N2 atmosphere at55 ¡ãC. Then, the temperature reaction was raised to 85 ¡ãC and themixture stirred for 16 h. Afterwards, the mixture was brought toroom temperature and later on placed in an ice bath for 1 h. Thesolid was filtered, washed with water and dichloromethane, anddried to constant weight.

The chemical industry reduces the impact on the environment during synthesis 3,5-Diamino-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Herna?ndez-Gil, Javier; Ferrer, Sacramento; Cabedo, Nuria; Lo?pez-Gresa, Mari?a Pilar; Castin?eiras, Alfonso; Lloret, Francesc; Journal of Inorganic Biochemistry; vol. 125; (2013); p. 50 – 63;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 7411-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

To a colorless solution of 3,5-dibromo-1H-1,2,4-triazole (lnt-1, 500 mg, 2.2 mmol) and 3-iodotetrahydrofuran (524 mg, 2.64 mmol) in DMF (3 ml) was added K2C03 (305 mg, 2.2 mmol). The vial was closed under Argon and stirred over night at 120C. The reaction mixture was diluted with 50 mL H20 and extracted with EtOAc (2 x 50 mL). The organic layers were washed with sat NaCl (3 x 50 mL), dried over MgS04 and concentrated in vacuo. The title compound was isolated as a white solid (619 mg, 2.08 mmol, 94.6 % yield). MS (ES+) m/z 297.9 [(M+H)+].

The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 4922-98-9, A common heterocyclic compound, 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, molecular formula is C8H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part C; A reaction mixture of compound 15-2 (79 mg, 0.3 mmol) and 3-phenyl-1 H- 1 ,2,4-triazol-5-amine (48 mg, 0.3 mmol) in AcOH (1 mL) was stirred at 160 0C for 20 minutes in microwave. Purification using reverse phase HPLC gave compound 15-3 after lyophilization.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann; WO2010/56631; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1533519-85-5, The chemical industry reduces the impact on the environment during synthesis 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, I believe this compound will play a more active role in future production and life.

For the 250 ml reaction bottle B join the previous step product (4 g, 0.0118 muM), tetrahydrofuran (30 ml), tetramethyl piperidine (TEMPO, 0.2 g, 0.1 eq), oil bath 30 – 32 C heating and stirring, to dissolve to clarify. Batch by adding N – bromo succinimide (NBS, 3.2 g, 0 . 018 muM, 1.5 eq), temperature control not more than 35 C. Canada finishes, thermal insulation 30 – 32 C reaction 3 h. Detection of the raw material after the reaction is complete, stop heating, ice bath cooling. To be in reaches warm 0 – 5 C, batch by adding sodium sulfite aqueous solution quenching reaction, ethyl acetate extraction, anhydrous sodium sulfate drying, filtering, and concentration, drying, and the produced intermediate C crude product can be directly used for the next step reaction. Analysis of the sample through the column chromatography (200 – 300 mesh silica gel, eluent is dichloromethane: methanol=15:1) purification, to obtain white solid C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shanghai Jingxin Bio-pharmaceutical Co., Ltd.; Dai Xiangqian; Huang Yue; (17 pag.)CN107098866; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 7170-01-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows.

Step 1. Preparation of 3-methyl-1-(4-nitrophenyl)-1H-1,2,4-triazole A mixture of 1-fluoro-4-nitrobenzene (1.54 g, 10.9 mmol), 3-methyl-1H-1,2,4-triazole (1.00 g, 12.0 mmol) and K2CO3 (1.66 g, 12.0 mmol) in DMF (30 ml) was stirred at 75 C. for 12 hours. After being cooled to room temperature, the reaction mixture was concentrated in vacuo. The mixture was dissolved in EtOAc, washed with saturated aq. NaHCO3, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex:EA=2:1) to give the desired product (0.500 g, 22%) as a brown solid. 1H NMR (400 MHz, CDCl3) delta 2.52 (3H, s), 7.85-7.88 (2H, m), 8.37-8.40 (2H, m), 8.58 (1H, s). LC-MS m/z=205.0 [M+H]+.

According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.; US2012/53180; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 4928-88-5, These common heterocyclic compound, 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 10 A mixture of methyl 1,2,4-triazole-3-carboxylate (1.27 g, 0.01 mole) and 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose (5.04 g, 0.01 mole) was melted and then 0.095 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 3 hours, while maintaining the temperature of the reaction mixture at 95+-5¡ã C. And then, the reaction mixture was crystallized with 25 ml of methanol to give 4.85 g of 1-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester (yield: 85percent). NMR (CDCl3) delta (ppm): 3.96(d, 3H), 4.67-4.80(m, 2H), 4.87(m, 1H), 6.11(t, 1H), 6.16(q, 1H), 6.34(d, 1H), 7.38-8.07(m, 15H), 8.44(s, 1H)

The synthetic route of 4928-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6523-49-5, SDS of cas: 6523-49-5

A mixture of formamidine from Step 1 (300 mg) and 4-triazolyl-aniline (167 mg, 1 eq) in AcOH (3 ml) was heated to 80 for 2 h. Cooled, and the resulting solid was isolated by filtration, washed with sodium bicarbonate, water and MeCN. The solid was purified by column chromatography on silica gel with DCM:EtOH:NH3 (400:8:1 to 200:8:1) as eluant to give the title compound.1H NMR delta 10.36 (IH, br s), 9.29 (IH, s), 8.93 (IH, s), 8.63 (IH, s), 8.25 (2H, m), 8.03 (3H, m), 7.86 (2H, d, J 9.25Hz), 7.81 (3H, m); LC-MS rt 2.61 m/z 418 ES+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 74205-82-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74205-82-6, name is (1H-1,2,4-Triazol-1-yl)methanol belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

Step 2–Preparation of 1-(chloromethyl)-1,2,4-triazole hydrochloride A 4 neck 1 liter flask equipped with condenser, addition funnel and mechanical stirrer was charged 45 gms of 1-(hydroxymethyl)-1,2,4-triazole (0.464 mole) in 500 ml of THF was heating to 40 C. with vigorous stirring. Then SOCl2 (61 ml, 0.84 mole) was added dropwise maintaining the temperature at 45 C. During the addition, a precipitate formed and the mixture was stirred for an additional 2 hours. The product was filtered, washed three times with ethyl acetate and vacuum dried at room temperature. 67.3 gms of product having a melting point of 118-130 C. resulted (94.2% yield).

The synthetic route of (1H-1,2,4-Triazol-1-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rohm and Haas Company; US5087635; (1992); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics