Triazoles

Adding a certain compound to certain chemical reactions, such as: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7411-23-6, SDS of cas: 7411-23-6

a) 3 ,5-Dibromo- 1 -ethyl- 1 H-[ 1 ,2,4]triazole 3,5-Dibromo-lH-l,2,4-triazole (2.5 g, 11.0 mmol, Eq: 1.00) was dissolved in dimethyl- formamide (31.8 ml) and sodium hydride (529 mg, 60% dispersion in mineral oil, 13.2 mmol, Eq: 1.2) was added slowly. Ethyl methanesulfonate (2.74 g, 2.27 ml, 22.0 mmol, Eq: 2) was added to the reaction and the mixture was heated in a microwave oven for 60 minutes at 100 C. The mixture was diluted with water and extracted 3x with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and the solvent was evaporated to give 3,5-dibromo-l-ethyl-lH- [l,2,4]triazole (2.54 g, 90.4%) as a white powder. MS: m/z= 255.9 (M+H+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KUHN, Bernd; LERNER, Christian; RUDOLPH, Markus; SCHAFFHAUSER, Herve; WO2013/178572; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 162848-16-0, name is 4-[1,2,4]Triazol-1-yl-benzoic acid, A new synthetic method of this compound is introduced below., category: Triazoles

General procedure: The ligand 4-Htba (0.1 mmol) was dissolved in DMF (5 mL), to which a DMF solution (5 mL) of Cd(NO3)2¡¤4H2O (0.1 mmol) was added with stirring for ca. 30 min. Then, the solution was sealed in a Teflon-linear autoclave and heated at 100 C for 3 days, after cooling to room temperature at a rate of 10 C/h, colorless blockc rystals of complex 1 were obtained in 58% yield (20.0 mg). Anal. Calcd for C10H7CdN3O4: C, 34.75; H, 2.04; N, 12.16%. Found: C, 34.71; H, 2.06; N, 12.14%. IR (KBr, cm-1): 1606vs, 1575vs, 1542vs, 1449m, 1410vs, 1368s, 1337s, 1303s, 1281s, 1229m, 1149m, 1051m, 994w, 975m, 873w, 854m, 812w, 781m, 724w, 698w, 669w, 646w, 541w. The same synthetic procedure as that for 1 was used except that Cd(NO3)2¡¤4H2O was replaced by Pb(NO3)2 (0.1 mmol), forming colorless block crystals of 2 in 54% yield (23.8 mg). Anal. Calcd for C10H7PbN3O4: C, 27.27; H, 1.60; N, 9.54%. Found: C, 27.22; H, 1.64; N, 9.49%. IR (KBr, cm-1): 1603s, 1557vs, 1383vs, 1340s, 1305m, 1277m, 1222m, 1143w, 1050w, 964w, 848w, 782m, 719w, 696w, 666w, 641w, 541w.

The synthetic route of 162848-16-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mu, Yu-Hai; Ge, Zhi-Wei; Li, Cheng-Peng; Inorganic Chemistry Communications; vol. 48; (2014); p. 94 – 98;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61-82-5, name is 1H-1,2,4-Triazol-5-amine, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61-82-5, HPLC of Formula: C2H4N4

A mixture of aldehyde (1 mmol), dimedone (1 mmol), 3-amino-1,2,4-triazole (1 mmol), and [C4(H-DABCO)2][HSO4]4 (16 mg) washeated in an oil bath (90 C) under solvent-free conditions. Aftercompletion of the reaction, as identified by TLC, using n-hexane:EtOAc (7:3) as the eluent, 10 mL of water was added and stirredfor 10 min. The catalyst was dissolved in water and the solid wasfiltered off and washed with warm EtOH, to obtain the pure targetmolecule.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 815588-93-3,Some common heterocyclic compound, 815588-93-3, name is 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ieri-butyl 6-amino-2-(2-(difluoromethyl)phenyl)-1 H-indole-1 -carboxylate (int 8) (358 mg, 1.00 mmol), 1 -methyl-1 H-1 ,2,4-triazole-5-carboxylic acid (454 mg, 2.00 mmol), HATU (570 mg, 1.50 mmol) and TEA (202 mg, 2.00 mmol) in DMF (4 m_) was stirred at rt overnight. Water (10 ml_) was added and the mixture was extracted with EtOAc (2 x 15 ml_). The combined organic layers were dried over MgS04, filtered and concentrated to dryness. The residue was purified by silica gel chromatography (gradient 30- 00 percent EtOAc in PE) to give the title compound as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid, its application will become more common.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; DEUSCHLE, UIrich; STEENECK, Christoph; ALBERS, Michael; HOFFMANN, Thomas; (62 pag.)WO2018/153893; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

162848-16-0, name is 4-[1,2,4]Triazol-1-yl-benzoic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 162848-16-0

A mixture of MIICl2 (0.25mmol) (M=Zn(1), Cd(2)), ligand Hcpt (0.5mmol), and DMF (10mL) was heated at room temperature to 150C for three days in a 25mL Teflonlined stainless-steel autoclave and was then cooled to room temperature at 5C/h-1 to obtain corresponding colorless block crystals 1-2 (yield: 53% for 1 and 49% for 2 based on MII). Anal.Calcd for 1 C18H12N6O4Zn (441.71): C, 48.90; H, 2.72; N, 19.02%. Found: C, 48.86; H, 2.75; N, 19.07%. IR frequencies (KBr, cm-1): 3443 (w), 3131 (w), 1682 (s), 1608 (s), 1568 (m), 1542 (m), 1504 (m), 1492 (m), 1462 (w), 1427 (w), 1384 (s), 1297 (s), 1219 (m), 1142 (s), 1045 (s), 1068 (m), 1002 (w), 975 (m), 955 (m), 860 (m), 809 (w), 771 (m), 690 (w), 670 (m), 638 (w), 559 (w), 538 (w), 516 (w). Anal.Calcd for 2 C24H26O6N8Cd (634.94): C, 45.36; H, 4.09; N, 17.64%. Found: C, 45.35; H, 4.11; N, 17.69%. IR frequencies (KBr, cm-1): 3425(mb), 2918(w), 1683(m), 1650(m), 1607(s), 1523(s), 1476(m), 1412(m), 1385(s), 1265(s), 1203(m), 1181(w), 1062(w), 858(m), 784(m), 722(w), 653(w), 619(w), 535(w), 524(w).

The synthetic route of 162848-16-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Teng; Liu, Xiang; Huang, Zhuang-Peng; Lin, Qiang; Lin, Chu-Ling; Zhan, Qing-Guang; Xu, Xiang-Dong; Cai, Yue-Peng; Inorganic Chemistry Communications; vol. 39; (2014); p. 70 – 74;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 40253-47-2, name is Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40253-47-2, Quality Control of Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate

To a mixture of ethyl 5-methyl-lH-l,2,4-triazole-3-carboxylate (200 mg, 1.29 mmol) in THF (5 mL) was added LiAIH4 (245 mg, 6.45 mmol) at 0C under N2. The mixture was stirred at 30C for 1 hour. The mixture was filtrated and washed with methanol, concentrated in vacuo to give(5-methyl-lH- l,2,4-triazol-3-yl)methanol (350 mg).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (275 pag.)WO2019/115566; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 1001401-62-2

compound (18.13 g) as a yellowTo a solution of 2-( H-I,2,34riazol-2-yl)benzoic acid (1.0 g, 5.3 mmoi) in toluene (10mL) was added with SOCl (0.77 mL, 10.6 mmol) at RT. The resulting mixture was stirred for I h at 0 C. After cooling to RT, the mixture was concentrated in vacuo to give colorless oil. This oil was dissolved in 6 mL of DCM and was added to a solution of the product from step I (1.0 g. 4.7 mmol) in DCM (6 mL). TEA (2.2 mL, 15.9 mmol) was added dropwise at () C. The mixture was stirred at this temperature for 3() min. The mixture was concentrated and theresidue was purified by chromatography on silica (33% EtOAc in petroleum ether) to givetitle compound (1,3 g) as a white solid. LRMS m/z (M+H) 287.1 found, 287.1 required.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 423165-07-5, name is exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

General procedure: To an aqueous solution of active hydrogen containing amide, few drops of aqueous ammonia solution (1 eq.) and secondary amine (1 eq.) were added in drops in an ice-cold solution under constant stirring for dissolution. Aromatic aldehydes dissolved in methanol, added dropwise to the above mixture and stirring was continued for 2 h. The formation of compounds were observed within 30 min. Reaction was monitored by TLC, after completion of reaction, the product was filtered and washed with distilled water and dried at 45-50 C.

The synthetic route of 423165-07-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Viveka, T. Lakshmi; Sharada, L. Nalanda; Asian Journal of Chemistry; vol. 30; 9; (2018); p. 2029 – 2034;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3,5-Diamino-1,2,4-triazole

Potassium tetranitropropane (200 mg, 0.67 mmol) was added to 20 mL of a mixed solvent of methanol and water (1:1 by volume), then concentrated hydrochloric acid (0.14 mL, 37%, 1.67 mmol) was added dropwise.Then, 3,5-diamino-1,2,4-triazole (293 mg, 1.34 mmol) was added and reacted at room temperature for 2 h. The reaction of the starting material was completely monitored by TLC, and a certain amount of NaHCO3 was added.Then add anhydrous magnesium sulfate to dry, spin dry, and pass the column (PE: EA = 4:1).A yellow solid 168 mg was obtained in 40% yield.

The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Yang Jun; Huang Haifeng; Shi Yameng; (17 pag.)CN110128344; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22300-52-3, name is 4,5-Dibromo-2H-1,2,3-triazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 22300-52-3

Step 2. tert-butyl 4-(4,5-dibromo-2H-l,2,3-triazol-2-yl)piperidine-l-carboxylate and tert-butyl 4-(4,5-dibromo-lH-l,2,3-triazol-l-yl)piperidine-l-carboxylate [0261] A mixture of 4,5-dibromo-2H-l,2,3-triazole (2.27 g, 10.08 mmol), tert-butyl 4- (methylsulfonyloxy)piperidine-l -carboxylate (2.79 g, 10.00 mmol), and cesium carbonate (9.75 g, 29.91 mmol) in N,N-dimethylformamide (50 mL) stirred overnight at 100 ¡ãC. The reaction mixture was cooled to room temperature, poured into water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to afford a mixture of tert-butyl 4-(4,5-dibromo-2H- 1 ,2,3- triazol-2-yl)piperidine- 1 -carboxylate and tert-butyl 4-(4,5-dibromo- 1 H- 1 ,2,3-triazol- 1 -yl)piperidine- 1-carboxylate (4.00 g, 97percent) as a yellow oil. MS (ESI, pos. ion) m/z 411 , 409, 413 [M+H]+. Step 3. tert-butyl 4-(4-bromo-2H-l,2,3-triazol-2-yl)piperidine-l-carboxylate (Intermediate 19) and tert-butyl 4-(4-bromo-lH-l,2,3-triazol-l-yl)piperidine-l-carboxylate (Intermediate 20) [0262] n-Butyllithium (2.5 M in hexanes, 2.92 mL, 7.30 mmol) was added dropwise to a -78 ¡ãC solution containing a mixture of tert-butyl 4-(4,5-dibromo-2H- 1,2, 3-triazol-2-yl)piperi dine- 1- carboxylate and tert-butyl 4-(4,5-dibromo-lH-l,2,3-triazol-l-yl)piperidine-l -carboxylate (3.00 g, 7.35 mmol) in tetrahydrofuran (20 mL). The resulting solution stirred for 1 hour at -78 ¡ãC, and then the reaction mixture was poured into saturated aqueous ammonium chloride solution (20 mL). The aqueous phase was separated and extracted with ethyl acetate (3 x 20 mL), and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The residue was purified via column chromatography on silica gel (eluting with 2: 1, ethyl acetate/petroleum ether) to afford tert-butyl 4-(4-bromo-2H-l,2,3-triazol-2-yl)piperidine-l- carboxylate (0. 800 g, 33percent) as a colorless oil. MS (ESI, pos. ion) m/z 331, 333[M+H]+. [0263] tert-Butyl 4-(4-bromo-lH-l ,2,3-triazol-l-yl)piperidine-l-carboxylate (0.500g, 20percent) was also obtained as a colorless oil. MS (ESI, pos. ion) m/z 331, 333 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 22300-52-3.

Reference:
Patent; BAIR, Kenneth W.; HERBERTZ, Torsten; KAUFFMAN, Goss Stryker; KAYSER-BRICKER, Katherine J.; LUKE, George P.; MARTIN, Matthew W.; MILLAN, David S.; SCHILLER, Shawn E. R.; TALBOT, Adam C.; WO2015/74064; (2015); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics