Triazoles

Kume, Masaharu’s team published research in Journal of Antibiotics in 46 | CAS: 59032-27-8

Journal of Antibiotics published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application In Synthesis of 59032-27-8.

Kume, Masaharu published the artcileOrally active cephalosporins. II. Synthesis and structure-activity relationships of new 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]cephalosporins with 1,2,3-triazole in C-3 side chain, Application In Synthesis of 59032-27-8, the publication is Journal of Antibiotics (1993), 46(1), 177-92, database is CAplus and MEDLINE.

The synthesis, antibacterial activity and oral absorbability of the title compounds I (X = CH₂S(CH₂)_n, S(CH₂)_m, SCH₂S(CH₂)_x, CH₂SCH₂S, S(CH₂)₂S, S(CH₂)₂O, S(CH₂)₂NH; n, m = 1-3, x = 0-2) are described. Their oral absorbability was influenced by the spacer length between C-3 of a cephem nucleus and C-4′ of 1,2,3-triazole. The SCH₂S structure was also found to contribute to their good oral absorption. The quant. relationship between the bioavailability and the spacer length of cephalosporins is discussed.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Cassani, Stefano’s team published research in Journal of Hazardous Materials in 258-259 | CAS: 53817-16-6

Journal of Hazardous Materials published new progress about 53817-16-6. 53817-16-6 belongs to triazoles, auxiliary class Triazoles, name is 1H-1,2,3-Triazole-4,5-dicarbonitrile, and the molecular formula is C4HN5, Computed Properties of 53817-16-6.

Cassani, Stefano published the artcileDaphnia and fish toxicity of (benzo)triazoles: Validated QSAR models, and interspecies quantitative activity-activity modeling, Computed Properties of 53817-16-6, the publication is Journal of Hazardous Materials (2013), 50-60, database is CAplus and MEDLINE.

Due to their chem. properties synthetic triazoles and benzo-triazoles ((B)TAZs) are mainly distributed to the water compartments in the environment, and because of their wide use the potential effects on aquatic organisms are cause of concern. Non testing approaches like those based on quant. structure-activity relationships (QSARs) are valuable tools to maximize the information contained in existing exptl. data and predict missing information while minimizing animal testing. Externally validated QSAR models for the prediction of acute (B)TAZs toxicity in Daphnia magna and Oncorhynchus mykiss have been developed according to the principles for the validation of QSARs and their acceptability for regulatory purposes, proposed by the Organization for Economic Co-operation and Development (OECD). These models are based on theor. mol. descriptors, and are statistically robust, externally predictive and characterized by a verifiable structural applicability domain. They were applied to predict acute toxicity for >300 (B)TAZs without exptl. data, many of which are in the pre-registration list of the REACH regulation. A model based on quant. activity-activity relationships (QAAR) has been developed, which allows for interspecies extrapolation from daphnids to fish. The importance of QSAR/QAAR, especially when dealing with specific chem. classes like (B)TAZs, for screening and prioritization of pollutants under REACH, has been highlighted.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Gibertson, Scott R. et al. published their research in Chemtracts in 2001 | CAS: 156311-83-0

Reaction microarrays: a method for rapidly determining the enantiomeric excess of thousands of samples was written by Gibertson, Scott R.. And the article was included in Chemtracts in 2001.SDS of cas: 156311-83-0 The following contents are mentioned in the article:

The title research (of G. A. Gorber, et al., 2001) is reviewed with commentary and 21 references This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0SDS of cas: 156311-83-0).

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zhang, Wei et al. published their research in Journal of Peptide Science in 2009 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Recommanded Product: 156311-83-0

Synthesis of the C-terminal pentapeptide of the peptaibol culicinins was written by Zhang, Wei;Sun, Tian-Tian;Li, Ying-Xia. And the article was included in Journal of Peptide Science in 2009.Recommanded Product: 156311-83-0 The following contents are mentioned in the article:

The synthesis of the C-terminal pentapeptide of culicinins has been achieved using [4 + 1] protocol and reduction-coupling strategy. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: 156311-83-0).

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Katritzky, Alan R. et al. published their research in ARKIVOC (Gainesville, FL, United States) in 2004 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

N-acylation in combinatorial chemistry was written by Katritzky, Alan R.;Suzuki, Kazuyuki;Singh, Sandeep K.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2004.Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

A review. Polymer-supported N-acylation utilizing carbodiimides with additives, direct coupling reagents (phosphonium salts and uronium salts), N-acylazoles, and other reagents are discussed. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Carpino, Louis A. et al. published their research in Tetrahedron Letters in 1994 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeElectric Literature of C17H27F6N7OP2

Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents was written by Carpino, Louis A.;El-Faham, Ayman;Albericio, ernando. And the article was included in Tetrahedron Letters in 1994.Electric Literature of C17H27F6N7OP2 The following contents are mentioned in the article:

1-Hydroxy-7-azabenzotriazole (HOAt) (I) and its corresponding uronium salts are more effective in avoiding racemization in a model solid-phase peptide segment coupling process than their benzotriazole analogs. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Electric Literature of C17H27F6N7OP2).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeElectric Literature of C17H27F6N7OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Garcia-Martin, Fayna et al. published their research in Peptide Science in 2010 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Novel coupling method for the incorporation of ‘complex’ amino acid was written by Garcia-Martin, Fayna;Hinou, Hiroshi;Matsushita, Takahiko;Nishimura, Shin-ichiro. And the article was included in Peptide Science in 2010.Recommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

A symposium report. Novel coupling method for glycosylated amino acids (models for “complex” amino acids) relies on the synergy of microwave energy, incorporation of only 1.2 equiv of amino acid, PEG-containing resins and “double-activation” method. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Subiros-Funosas, Ramon et al. published their research in Chimica Oggi in 2008 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Category: triazoles

PyClocK, the phosphonium salt derived from 6-Cl-HOBt was written by Subiros-Funosas, Ramon;Moreno, Juan A.;Bayo-Puxan, Nuria;Abu-Rabeah, Khalil;Ewenson, Ariel;Atias, Danit;Marks, Robert S.;Albericio, Fernando. And the article was included in Chimica Oggi in 2008.Category: triazoles The following contents are mentioned in the article:

Novel phoshphonium salts of benzotriazoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are described. Further described is a process of preparing the novel phosphonium salts and methods for preparing peptides. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Category: triazoles).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Carpino, Louis et al. published their research in Journal of the Chemical Society, Chemical Communications in 1994 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.HPLC of Formula: 156311-83-0

Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis was written by Carpino, Louis;El-Faham, Ayman;Minor, Charles A.;Albericio, Fernando. And the article was included in Journal of the Chemical Society, Chemical Communications in 1994.HPLC of Formula: 156311-83-0 The following contents are mentioned in the article:

1-Hydroxy-7-azabenzotriazole (HOAt) and its corresponding uronium and phosphonium salts are shown to be superior to their benzotriazole analogs in solid-phase peptides synthesis, thereby making possible the automated synthesis of peptides containing hindered amino acids. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0HPLC of Formula: 156311-83-0).

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Khan, Misbahul Ain et al. published their research in Revista Latinoamericana de Quimica in 1972 | CAS: 39876-84-1

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Safety of 2-(1,2,4-Triazol-1-yl)aniline

Synthesis of heterocyclic compounds. III. Aryl-1,2,4-triazoles was written by Khan, Misbahul Ain;Polya, J. B.. And the article was included in Revista Latinoamericana de Quimica in 1972.Safety of 2-(1,2,4-Triazol-1-yl)aniline The following contents are mentioned in the article:

The aryltriazoles I-III (R = H, o-, p-NO2, o-, m-, p-Ph) were prepared An RC6H4NHNH2 reacted with Me2NCH:NCH:N+Me2 Cl- to give I. RC6H4NH2 condensed with HCONHNHCHO to give II. The Gomberg-Bauchmann arylation reaction of III (R = NH2) gave III (R = Ph, o-NO2C6H4, p-NO2C6H4). This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Safety of 2-(1,2,4-Triazol-1-yl)aniline).

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics