Triazoles

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3-Methyl-1H-1,2,4-triazole

The 5-chloro-6-methyl-pyrazolo [1,5-a] pyrimidine-3-carboxylic acid butyl 3rd (607 mg) for N, N- dimethyl formamide (39.8 ml) is added a solution of 4-methyl -1H-1, 2, 3-triazole (208 mg) and potassium carbonate (378 mg). The reaction mixture is stirred at room temperature for 2 hours, to be added, and the mixture is extracted with ethyl acetate. Extract water and saturated salt water cleaning, drying with anhydrous sodium sulfate, and the evaporation of the solvent under reduced pressure. Aid hemostasis by silica gel column chromatography purification (hexane/ethyl acetate), in order to produce the title compound (167 mg).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3-Methyl-1H-1,2,4-triazole, in my other articles.

Reference:
Patent; TAKED A PHARMACEUTICAL COMPANY LIMITED; KAWASAKI, MASANORI; MIKAMI, SATOSHI; NAKAMURA, SHINJI; NEGORO, NOBUYUKI; IKEDA, SHUHEI; ASHIZAWA, TOMOKO; MARUI, SHOGO; TANIGUCHI, TAKAHIKO; (135 pag.)TW2016/520; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 7411-23-6, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

To a suspension of NaH (60% in mineral oil, 387.9 mg, 9.7 mmol) in THF (20 mL) at 0C is added a solution of A6a (2.0 g, 8.8 mmol, Matrix) in THF (20 mL). The reaction mixture is allowed to warm to RT and is stirred for 30 mm. It is then cooled again to 0C and A6b (1 .9 mL,10.6 mmol, Combi Blocks) is added. The reaction mixture is stirred overnight at RT and diluted with EtOAc (50 mL). The organic layer is washed with water (30 mL) and brine (30 mL), dried over MgSO4, and filtered. The filtrate is concentrated to give A6c which is used without further purification.

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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FADER, Lee; BILODEAU, Francois; POIRIER, Maude; PARISIEN, Mathieu; KUHN, Cyrille; THIBEAULT, Carl; TRINH, Thao; WO2014/70978; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 16681-65-5, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16681-65-5, name is 1-Methyl-1H-1,2,3-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7.1 : 1 -Methyl-1 H-[1 ,2,3]triazole (1 .50 g; 17.150 mmol) was dissolved in dry THF (30.0 mL) under argon and cooled to -65 C. Butyllithium (2.5 M in hexane; 6.86 mL; 17.150 mmol) was added dropwise over a period of 10 min. The temperature was hold between -65 C and -60 C. A colorless suspension was formed, which was stirred at – 65 C for 1 h. 1 -Methyl-1 H- pyrazole-4-carbaldehyde (1 .89 g; 17.150 mmol), dissolved in dry THF (10.0 mL), was added dropwise at -65 C and the mixture stirred at – 65 C for 15 min. The reaction mixture was slowly warmed to 0 C within 1 .5 h and then quenched with methanol (10 ml_) and evaporated to dryness. The crude residue was dissolved in dry THF (50.0 ml_) and water (15.0 ml_). (0380) Manganese(IV) oxide (2.98 g; 34.299 mmol) was added, and the mixture was stirred at 80 C overnight. Manganese(IV) oxide (2.98 g; 34.299 mmol) was added and the mixture was stirred for further 24 h at 80 C. The mixture was filtered over kieselguhr. The residue was washed with dichloro- methane/methanol(30%). The combined filtrates were evaporated to an aqueous residue. A precipitate was formed, which was filtered by suction and washed with little water, acetonitrile and MTBE and dried under vacuum at 50 C for 1 h. The filtrate was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with sodium sulfate, filtered by suction and evaporated to dryness. The solid residue was triturated with little acetonitrile, filtered by suction and washed with little acetonitrile and MTBE, and dried under vacuum at 50 C for 1 h. Yield: 2.38 g colorless solid; (0381) LC/MS, Rt: 1 .29 min; (M+H) 192.2

This is the end of this tutorial post, and I hope it has helped your research about 16681-65-5!

Reference:
Patent; MERCK PATENT GMBH; BUCHSTALLER, Hans-Peter; (101 pag.)WO2018/87021; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.61-82-5, name is 1H-1,2,4-Triazol-5-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 61-82-5

General procedure: 20 mg of gamma-Fe2O3Ph-PMO-NaHSO4 was added to a roundbottomflask containing an aromatic aldehyde (1 mmol), 3-amino-1,2,4-triazole 2 (1.0 mmol), b-diketones (dimedone 3, 1,3-cyclohexadione 4 or ethyl acetoacetate 5) (1.0 mmol) and stirredunder solvent-free conditions at 100 C in certain times. Meanwhile,the progress of the reactionwas indicated by TLC (n-hexane:ethyl acetate; 7:3). With completing the reaction, 3ml ethanol waspoured and the magnetic nanocomposite was separated in thepresence of a magnetic stirring bar; the reaction mixture becameclear. The crude product was recrystallized from ethanol to give thepure product. The pure products were characterized by conventionalspectroscopic methods. Physical and spectral data for theselected compounds are represented below.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1H-1,2,4-Triazol-5-amine ,and how the biochemistry of the body works.

Reference:
Article; Haghighat, Mahdieh; Shirini, Farhad; Golshekan, Mostafa; Journal of Molecular Structure; vol. 1171; (2018); p. 168 – 178;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 7411-23-6, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

In a 50 mL round bottomed flask, 3,5-dibromo-1H-1,2,4-triazole (lnt-1, 500 mg, 2.2 mmol) was dissolved in DMF (8 mL) and potassium carbonate (680 mg, 4.87 mmol) was added. After stirring for 20 min at room temperature, 2,2,3,3, 3-pentafluoropropyl trifluoromethanesulfonate (705 mg, 414 mu, 2.42 mmol) was added and the reaction mixture was stirred for 20 h at room temperature. After that, it was concentrated in vacuo, the residue was purified by column chromatography (silica gel, 50 g, eluting with ethyl acetate / n-heptane, gradient 20:80 to 50:50 v/v) to yield the title compound as white solid (409 mg, 52%). HPLC (methodLCMS_fastgradient) tR= 1.11 min. 1H NMR (CDCl3, 300 MHz): delta 4.78 (t, J = 13.4 Hz, 2 H). MS (ES+) mJz 357.9, 359.9, 361.9 [M+H, 2 Br isotopes].

We very much hope you enjoy reading the articles and that you will join us to present your own research about 7411-23-6, Happy reading!

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1157938-97-0, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 1157938-97-0, name is 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen, in a 250 ml three-necked flaskZinc powder (11.7 g, 179 mmol, 4.0 eq.) AndTHF (200 ml), TMSCl (2.25 ml) was added,Stirring 30min at room temperature, ice salt bath temperature to 0 ,Ethyl 2-bromopropionate (11.6 mL, 89.6 mmol, 2.0 eq.) Was added dropwise and stirring was continued at 0 C for 30 min,The suspended matter was filtered off under nitrogen flow,The filtrate was transferred to a 500 ml three-neck flask;1- (2,5-difluorophenyl) -2- (1 -hydro-1,2,4-triazol-1-yl) ethanone (10 g, 44.8 mmol, 1.0 eq.Was dissolved in THF (130 ml)The filtrate (200 ml) was added dropwise at room temperature, and the stirring was continued for 72 hours.A solid was produced and filtered to give an off-white solid,3-hydroxy-2-methyl-4- (1 -hydro-1,2,4-triazol-1-yl) butanoic acid ethyl ester;A mixture of crude ethyl 3- (2,5-difluorophenyl) -3-hydroxy-2-methyl-4- (1 -hydro- 1,2,4-triazol-(12.7 g) was suspended in EA (100 mL)Water (50 mL) was added, and when pH = 1 was adjusted with 6N hydrochloric acid,Into a clear two-phase, liquid separation, aqueous phase with EA (50mL)Extraction was carried out twice, the EA phase was combined, washed with saturated brine,Dried over anhydrous sodium sulfate, filtered, concentrated,To give a pale yellow solid, i. EEthyl 3- (2,5-difluorophenyl) -3-hydroxy-2-methyl-4- (1 -hydro-1,2,4-triazol-1-yl) butanoate Purified product(8.8 g, 27 mmol, 60% yield, greater than 99% d.e.).

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is helpful to your research.

Reference:
Patent; Sichuan Kelun Drug Research Institute Co., Ltd.; Chen, Li; Duan, Jilong; Li, Yang; Li, Donghong; Ge, Jianhua; Wang, Lichun; Hu, Siyu; Zhao, Dong; Wang, Jingyi; Huang, Qingdong; (14 pag.)CN105801500; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 288-36-8, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

To a solution of 0.87 g (8.4 mmol) of 2-chloroimidazole in 14 mL of DMF was added 0.40 g (10 mmol) of 60% NaH in mineral oil. After 20 min of stirring, 2.5 g (8.4 mmol) of 4-bromo-2-tert-butoxycarbonylamino-butyric acid methyl ester in 5 mL of DMF was added. The reaction mixture was heated to 80 C for 1 h. The mixture was diluted with EtOAc (150 mL), washed with water, brine, dried over MgSO4, filtered, and concentrated. The residue was purified by flash chromatography (0-5% MeOH in CH2C12) to provide 2.1 g (78%) of 2-tert-butoxycarbonylamino-4-1,2,3-triazol-2-yl- butyric acid methyl ester.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 1H-1,2,3-Triazole.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/70485; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 956317-36-5, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A round-bottom flask equipped with a magnetic stirrer bar was charged with 5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoic acid (5.0 g, 24.6 mmol, 1.0 equiv) and THF (250 mL). Theresulting solution was cooled to 0 C, followed by successive addition of triethyl amine (3.58 mL, 25.8 mmol, 1.05 equiv) and isobutyl chloroformate (3.35 mL, 25.8 mmol,1.05 equiv). The reaction mixture was stirred at ambient temperature for 1 h. Subsequently, the precipitate was filtered off and the filtrate was concentrated under reduced pressure.The residue was taken up in ethyl acetate and washed with saturated NaHCO3 solution. The organic layer was washed with H20, dried over anhydrous sodium sulfate and concentrated under reduced pressure, yielding (isobutyl carbonic) 5-methyl-2-(2H-1,2,3- triazole-2-yl)benzoic anhydride (6.6 g, 88%) as an orange-brown oil.?H NMR (500 MHz, CDC13) oe = 7.80 (s, 2H), 7.70 (d, J = 8.20 Hz, 1H), 7.64 (d, J = 1.45Hz, 1H), 7.45 (dd, J = 1.45, 8.20 Hz, 1H), 3.98 (d, J = 6.60 Hz, 2H), 2.42 (s, 3H), 1.96(sept, J = 6.71 Hz, 1H), 0.91 (d, J = 6.75 Hz, 6H)?3C NMR (125 MHz, CDC13) oe = 161.0, 148.6, 139.0, 136.4, 135.9, 133.8, 131.2, 124.3, 124.1, 75.4, 27.6, 20.9, 18.7

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid.

Reference:
Patent; SANDOZ AG; HOeFERL-PRANTZ, Kathrin; BARTH, Roland; RICHTER, Frank; ZUPANCIC, Borut; (126 pag.)WO2016/20403; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 59660-30-9, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 59660-30-9, name is (4-Methyl-4H-[1,2,4]triazol-3-yl)methanol, molecular formula is C4H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Reaction of 3-hydroxymethyl- 4-methyl-1,2,4-triazole with cysteamine hydrochloride and hydrobromic acid by the procedure of Example 1 gives 3-[(2-aminoethyl)thiomethyl]-4-methyl-1,2,4-triazole dihydrobromide, m.p. 175-177.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about (4-Methyl-4H-[1,2,4]triazol-3-yl)methanol is helpful to your research.

Reference:
Patent; Smith Kline & French Laboratories Limited; US3950333; (1976); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

The reaction flask was sequentially charged with 5-methyl-2- (2H- 1,2,3-triazol-2-yl) benzoic acid (4.65 g, 22.89 mmol)N, N-dimethylformamide (3 drops), dichloromethane (52 mL), thionyl chloride (2.79 mL, 34.33 mmol)The system was stirred at room temperature for 2 hours. Then, the reaction system was concentrated under reduced pressure at 40 C,5.06 g of 5-methyl-2- (2H-1,2,3-triazol-2-yl) benzoyl chloride was obtained as a yellow oil.

If you are hungry for even more, make sure to check my other article about 956317-36-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; He Bifei; Liu Guangyuan; Fan Yuping; Wang Zhongqing; Luo Zhonghua; (10 pag.)CN107304204; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics