Muttenthaler, Markus et al. published their research in Journal of Medicinal Chemistry in 2010 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 156311-83-0

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering was written by Muttenthaler, Markus;Andersson, Asa;de Araujo, Aline D.;Dekan, Zoltan;Lewis, Richard J.;Alewood, Paul F.. And the article was included in Journal of Medicinal Chemistry in 2010.Recommanded Product: 156311-83-0 The following contents are mentioned in the article:

Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogs of oxytocin were synthesized including disulfide bond replacements by thioether, selenylsulfide, diselenide, and ditelluride bridges, and their stabilities in human plasma and activity at the human oxytocin receptor were assessed. The cystathionine (Ki = 1.5 nM, and EC50 = 32 nM), selenylsulfide (Ki = 0.29/0.72 nM, and EC50 = 2.6/154 nM), diselenide (Ki = 11.8 nM, and EC50 = 18 nM), and ditelluride analogs (Ki = 7.6 nM, and EC50 = 27.3 nM) retained considerable affinity and functional potency as compared to oxytocin (Ki = 0.79 nM, and EC50 = 15 nM), while shortening the disulfide bridge abolished binding and functional activity. The mimetics showed a 1.5-3-fold enhancement of plasma stability as compared to oxytocin (t1/2 = 12 h). By contrast, the all-D-oxytocin and head to tail cyclic oxytocin analogs, while significantly more stable with half-lives greater than 48 h, had little or no detectable binding or functional activity. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Meldal, Morten et al. published their research in Angewandte Chemie, International Edition in 2010 | CAS: 156311-83-0

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Microparticle Matrix Encoding of Beads was written by Meldal, Morten;Christensen, Soeren Flygering. And the article was included in Angewandte Chemie, International Edition in 2010.Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

The authors present a versatile, simple encoding principle that may solve many problems in solid-phase screening and decoding: optical microparticle matrix encoding (MPM encoding) with fluorescent microparticles. The utility of this technique has been demonstrated in the identification of avidin ligands from a focused library, in which compounds could not be distinguished with mass spectrometric methods. The library design was based upon previously reported L– and D-amino acid libraries for avidin and streptavidin, thus indicating selectivity for aromatic residues. Uniform 10 μm Tentagel microparticles labeled with a chem. stable fluorophore ATOTA [tris(dialkylamino)trioxatriangulenium ion] were randomly distributed in a bis(acrylamido)polyethylene glycol (PEG) macromonomer (64,000 cm-3) by ultrasound and homogenization. Inverse suspension polymerization of the microparticle-containing macromonomer in the presence of bis(tert-butyldiphenylmethylsilyl)PEG1500 stabilizer provided 500,000 uniform, amino-functionalized, uniquely encoded beads (72 mL; ca 6.5 g dry weight), which contained an average of 8 microparticles per bead, with a bead size of (550±100) μm. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Hongxin’s team published research in Tetrahedron Letters in 59 | CAS: 219508-27-7

Tetrahedron Letters published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Li, Hongxin published the artcileSolution-processable high-efficiency bis(trifluoromethyl)phenyl functionalized phosphorescent neutral iridium(III) complex for greenish yellow electroluminescence, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Tetrahedron Letters (2018), 59(18), 1748-1751, database is CAplus.

A novel and highly efficient bis(trifluoromethyl)phenyl functionalized iridium(III) complex is designed and synthesized. The complex shows intensive greenish yellow phosphorescence (525 nm with 563 nm as shoulder), high photoluminescence efficiency (0.90) and moderate full width at half maximum (72 nm). The bulky bis(trifluoromethyl)phenyl moiety introduced into the complex provides the excellent solubility and effective steric hindrance for solution-processed organic light-emitting diodes. The maximum power efficiency and current efficiency of electroluminescence are 4.13 lm/W and 9.54 cd/A, resp.

Tetrahedron Letters published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Toda, Fumio’s team published research in Chemistry Letters in | CAS: 63598-71-0

Chemistry Letters published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C11H12O4, COA of Formula: C2H3N3.

Toda, Fumio published the artcileFreezing the equilibrium of 1,2,4-triazole by complex formation with 1,1-bis(2,4-dimethylphenyl)-2-butyn-1-o1, and x-ray crystal structure of the complex, COA of Formula: C2H3N3, the publication is Chemistry Letters (1987), 2317-20, database is CAplus.

Of the two tautomeric isomers of 1,2,4-triazole, 1,2,4-triazacyclopenta-3,5-diene and 1,2,4-triazacyclopenta-2,5-diene, the former was isolated as a 1:1 complex with the title host compound X-ray anal. of the complex reveals that the two mol. components are linked by hydrogen bonds.

Chemistry Letters published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C11H12O4, COA of Formula: C2H3N3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Enmanji, Koe’s team published research in Nippon Kagaku Kaishi in | CAS: 63598-71-0

Nippon Kagaku Kaishi published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Computed Properties of 63598-71-0.

Enmanji, Koe published the artcileEstimation of the relative efficiency of antioxidants by using the decolorization rates of a nickel dithiolate complex, Computed Properties of 63598-71-0, the publication is Nippon Kagaku Kaishi (1979), 796-8, database is CAplus.

Fading phenomena of a solution of bis[4-(dimethylamino)dithiobenzil]nickel(0) complex in 1,2-dichloroethane were investigated in the presence of THF as a radical generator. The decoloration proceeded as a 1st order reaction with respect to the concentration of the Ni complex and a half order with respect to the concentration of THF. Effects of some antioxidants on the fading rates were also examined

Nippon Kagaku Kaishi published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Computed Properties of 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Gyoneva, Stefka’s team published research in Neuroscience (Amsterdam, Netherlands) in 330 | CAS: 377727-87-2

Neuroscience (Amsterdam, Netherlands) published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C25H29N9O3, Name: 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine.

Gyoneva, Stefka published the artcileAltered motility of plaque-associated microglia in a model of Alzheimer’s disease, Name: 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, the publication is Neuroscience (Amsterdam, Netherlands) (2016), 410-420, database is CAplus and MEDLINE.

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain’s resident immune cells, which likely participate in the clearance of Aβ by phagocytosis. The microglia that are associated with plaques display an abnormal ameboid morphol. and do not respond to tissue damage, in contrast to microglia in healthy brains. Here, we used time lapse confocal microscopy to perform a detailed real-time examination of microglial motility in acute hippocampal brain slices from the 5xFAD mouse model of AD, which was crossed to Cx3cr1GFP/GFP mice to achieve microglia-specific GFP expression for visualization. During baseline conditions, microglia around plaques appeared hypermotile, moving the processes that were pointing away from plaques at higher speed than microglia not associated with plaques. Yet, neither plaque-associated, nor plaque-free microglia were able to extend processes toward sites of modest mech. damage. Application of the selective adenosine A2A receptor antagonist preladenant, which restores microglial response to cellular damage in a mouse model of Parkinson’s disease, reduced the hypermotility of plaque-associated microglia, but did not restore motility toward damaged cells in slices from 5xFAD mice. Our results suggest that process hypermotility and resistance to A2A antagonism during response to tissue damage may represent unique functional phenotypes of plaque-associated microglia that impair their ability to function properly in the AD brain.

Neuroscience (Amsterdam, Netherlands) published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C25H29N9O3, Name: 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Liu, Yuqi’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 1 | CAS: 219508-27-7

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Liu, Yuqi published the artcileDFT/TDDFT investigation on the electronic structures and photophysical properties of phosphorescent Ir(III) complexes with conjugated/non-conjugated carbene ligands, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2013), 1(23), 3700-3709, database is CAplus.

A DFT/TDDFT study was performed on the electronic structures, basic photophys. properties and potential OLED applications of Ir(III) complexes [(fpmb)2Ir(fptz)] (1a), [(dfpmb)2Ir(fptz)] (2a), [(fpmb)2Ir(bptz)] (3a), [(dfpmb)2Ir(bptz)] (4a) [where H2fpmb = 1-(4-fluorophenyl)-2,3-dihydro-3-methyl-1H-benzo[d]imidazole; H2dfpmb = 1-(2,4-fluorophenyl)-2,3-dihydro-3-methyl-1H-benzo[d]imidazole; fptzH = 2-(5-(trifluoromethyl)-2H-1,2,4-triazol-3-yl)pyridine; bptzH = 4-tert-butyl-2-(5-(trifluoromethyl)-2H-1,2,4-triazol-3-yl)pyridine] and [(fbmb)2Ir(fptz)] (1b), [(dfbmb)2Ir(fptz)] (2b), [(fbmb)2Ir(bptz)] (3b), [(dfbmb)2Ir(bptz)] (4b) [where H2fbmb = 1-(4-fluorobenzyl)-2,3-dihydro-3-methyl-1H-benzo[d]imidazole; H2dfbmb = 1-(2,4-fluorobenzyl)-2,3-dihydro-3-methyl-1H-benzo[d]imidazole] bearing two conjugated and non-conjugated carbene ligands, resp., and one blue-emitting chromophore that possesses a much larger ligand energy gap. The photophys. properties of these complexes are greatly affected by the properties of the adopted ligands. From 1b to 4b, the insertion of a saturated σ-bond methylene spacer into the carbene ligand renders an increase of the HOMO-LUMO energy gap, but relatively weak absorption intensities. The emission spectra are slightly influenced by the switch between conjugated and non-conjugated ligands. Also, from the calculations, the significantly higher quantum yield of 2b and 3b with respect to 3a is also explained with the assistance of their larger metal contribution to the lowest excited states (MLCT%) and smaller S1-T2 splitting energies (ΔES1-T2). Besides, the designed complexes 1b and 4b are considered to be potential candidates as blue-emitting materials with good charge transfer properties and high quantum efficiency.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Xu, Huixia’s team published research in Dyes and Pigments in 134 | CAS: 219508-27-7

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C12H17NO2, Formula: C8H5F3N4.

Xu, Huixia published the artcileSolution-processed blue and blue-green phosphorescent organic light-emitting devices using iridium(III) complexes based on 9-(6-(4-phenyl-1H-1,2,3-triazol-1-yl)hexyl)-9H-carbazole ligand, Formula: C8H5F3N4, the publication is Dyes and Pigments (2016), 148-154, database is CAplus.

We have designed and successfully synthesized a series of solution-processed iridium(III) complexes of (Czphtz)2Ir(NN) bearing main ligand of 9-(6-(4-phenyl-1H-1,2,3 -triazol-1-yl)hexyl)-9H-carbazole, namely (Czphtz)2Ir(tfmptz) (Ir1) (Czphtz)2Ir(pptz) (Ir2) and (Czphtz)2Ir(fpptz) (Ir3). The hole-transporting carbazole and electron-transporting 1, 2, 4-trizole moieties were introduced through hexyl to balance carrier transport. The solution-processed host-free and doped phosphorescent organic light-emitting devices (PhOLEDs) were fabricated. Here, in this paper, we will present the photophys., electrochem. properties and performances in devices of three complexes. All of them exhibit excellent solubilities in common organic solvents. The pure-blue-light-emitting Ir1 with the maximum emission peak at 463 nm was attained by varying the structure of ancillary ligand and have the CIE coordinate of (0.19, 0.18) in host-free PhOLED. Our work shows that the rational structure modification of ancillary ligand is an effective approach to develop deep blue-light-emitting materials.

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C12H17NO2, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Hu, Xiaoyan’s team published research in Huaxue Yanjiu Yu Yingyong in 22 | CAS: 86386-77-8

Huaxue Yanjiu Yu Yingyong published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Hu, Xiaoyan published the artcileSynthesis and antifungal activity of triazole derivatives, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is Huaxue Yanjiu Yu Yingyong (2010), 22(12), 1573-1577, database is CAplus.

To study the antifungal mechanism and structure-activity relationship of the azole compounds, four triazole compounds were designed and synthesized. The said triazole derivatives, e.g., I, were prepared via Friedel-Crafts acetylation of 1,3-difluorobenzene with chloroacetyl chloride; the resulting α-chloro-2,4-difluoroacetophenone underwent condensation with 1,2,4-triazole to give α-(1,2,4-triazol-1-yl)-2,4-difluoroacetophenone, which underwent cyclization to give 1-[2-(2,4-difluorophenyl)-1,2-epoxy-3-propyl]-1H-1,2,4-triazole, which underwent additive ring-opening with Et 1-piperazinecarboxylate to give 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(4-ethoxycarbonylpiperazin-1-yl)propan-2-ol, which underwent hydrolysis to give 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(piperazin-1-yl)propan-2-ol, which underwent N-alkylation with alkyl halides to give the title compounds All of them were confirmed by 1H-NMR and MS spectra. Antifungal activities of title compounds were evaluated. And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C. albicans and C. neoformans. Two of the compounds showed higher activity than fluconazole.

Huaxue Yanjiu Yu Yingyong published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Filippova, Yuliya V.’s team published research in Journal of Heterocyclic Chemistry in 49 | CAS: 14544-45-7

Journal of Heterocyclic Chemistry published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Computed Properties of 14544-45-7.

Filippova, Yuliya V. published the artcileAcid Catalyzed tert-Butylation and Tritylation of 4-Nitro-1,2,3-triazole: Selective Synthesis of 1-Methyl-5-nitro-1,2,3-triazole via 1-tert-Butyl-4-nitro-1,2,3-triazole, Computed Properties of 14544-45-7, the publication is Journal of Heterocyclic Chemistry (2012), 49(4), 965-968, database is CAplus.

4-Nitro-1,2,3-triazole was found to react with tert-butanol in concentrated sulfuric acid to yield 1-tert-butyl-4-nitro-1,2,3-triazole as the only reaction product, whereas tert-butylation and tritylation of 4-nitro-1,2,3-triazole in presence of catalytic amount of sulfuric acid in benzene was found to provide mixtures of isomeric 1- and 2-alkyl-4-nitro-1,2,3-triazoles with predominance of N2-alkylated products. A new methodol. for preparation of 1-alkyl-5-nitro-1,2,3-triazoles from 1-tert-butyl-4-nitro-1,2,3-triazole via exhaustive alkylation followed by removal of tert-Bu group from intermediate triazolium salts was demonstrated by the example of preparation of 1-methyl-5-nitro-1,2,3-triazole.

Journal of Heterocyclic Chemistry published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Computed Properties of 14544-45-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics