Triazoles

In 2019.0 MED CHEM RES published article about GANCICLOVIR; INHIBITION; MUTATIONS in [Kachaeva, Maryna V.; Pilyo, Stepan G.; Zhirnov, Victor V.; Brovarets, Volodymyr S.] NAS Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, Dept Chem Bioact Nitrogen Containing Heterocycl B, 1 Murmanskaya Str, UA-02094 Kiev, Ukraine; [Hartline, Caroll B.; Harden, Emma A.; Prichard, Mark N.] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL 35233 USA in 2019.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC50:<0.05M) against a normal laboratory HCMV strain (AD-169) in human foreskin fibroblast cells than Ganciclovir (EC50=0.32M), an anti-HCMV agent in clinical use. Additionally, the HCMV-resistant isolate (GDGr K-17) was tested for sensitivity to 1,3-oxazole derivatives with most antiviral potency against the strain AD169. A one of them (5-((2-hydroxyethyl)(methyl)amino)-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile) showed very high potency (EC50:<0.05; CC50: >150 mu M, and SI50=3125) towards the resistant isolate compared to standard drugs Cidofovir (EC50=0.10 mu M, CC50: >30 mu M and SI50: <4). But, in contrast to the primary assays, the antiviral activity of these compounds against both the normal strain and the resistant isolate of HCMV were considerably less than one of Cidofovir in secondary assay. These results provided evidence that derivatives of 1,3-oxazole could be useful for developing new anti-HCMV drugs. Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Seyf, JY; Asgari, M in [Seyf, Jaber Yousefi] Hamedan Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran; [Asgari, Mohammad] Sharif Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran published Correlation and prediction of small to large sized pharmaceuticals solubility, and crystallization in binary and ternary mixed solvents using the UNIQUAC-SAC model in 2020.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The recently reported UNIversal QUAsiChemical Segment Activity coefficient (UNIQUAC-SAC) model [developed by Haghtalab and Yousefi Seyf Ind. Eng. Chem. Res. 2015, 54, 8611] provides a practical thermodynamic framework to be used in VLE, LLE, and SLE calculations. The UNIQUAC-SAC model has the advantage of being independent of area (q) and volume (r) structural parameters used in the combinatorial part. While the UNIFAC or UNIFAC-DMD could not apply to the 47% (44 of 94) of the studied molecules because of the undefined groups. Here, the numbers of solvents with identified segment numbers were extended from 82 to 130 with a slight refinement to the previous values. The model parameters obtained via a large consistent set of VLE (isobaric and isothermal), and LLE experimental data. Also, the model was tested with pharmaceutical solubility experimental data in pure (94 solutes with 6210 solubility data), binary, and ternary solvents. The model provides a robust correlation of pharmaceuticals solubility in a mono-solvent and robust prediction of pharmaceuticals solubility in mixed solvents. The UNIQUAC-SAC model was successfully evaluated in solvent screening in cooling crystallization of ibuprofen and valsartan in both pure and binary solvents mixture (combined cooling and anti-solvent crystallization). The model with 130 solvents as a robust database provides a useful and practical thermodynamic tool in the conceptual design of pharmaceutical processes. A MATLAB based graphical user interface (GUI), finally, was developed to be used in the conceptual segment numbers regression procedure. (C) 2020 Elsevier B.V. All rights reserved.

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Seyf, JY; Asgari, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Dual-functionalized ZIF-8 as an efficient acid-base bifunctional catalyst for the one-pot tandem reaction WOS:000589899500008 published article about METAL-ORGANIC FRAMEWORK; DEACETALIZATION; CONDENSATION; HYDROGEN; SITES in [Lee, Yu-Ri; Do, Xuan Huy; Hwang, Seung Sang; Baek, Kyung-Youl] Korea Inst Sci & Technol, Mat Architecturing Res Ctr, Seoul 02792, South Korea; [Do, Xuan Huy; Baek, Kyung-Youl] Korea Univ Sci & Technol, KIST Sch, Div Nano Informat Technol, Seoul 02792, South Korea; [Baek, Kyung-Youl] Korea Res Inst Chem Technol, Ctr Convergent Chem Proc, 141 Gajeong Ro, Daejeon 34114, South Korea in 2021.0, Cited 29.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

An acid-base bifunctional zeolitic imidazolate framework catalyst (ZIF8-A61-SO3H) with amine and sulfonic acid groups was successfully prepared through simple two step post-synthetic modification: preparation of aminefunctionalized ZIF-8 with amine contents of 61% (ZIF8-A61) by the ligand exchange of 2-mIM with 3-amino1,2,4-triazole (Atz), followed by the sulfonic acid functionalization by the ring-opening reaction of 1,3-propanesultone with -NH2 groups in ZIF8-A61. Amine-functionalized ZIF8-A materials with difference amine contents (15%, 34%, and 61%, respectively) were also prepared by controlling the synthesis time. All obtained ZIF catalysts evaluated as a heterogeneous catalyst for one-pot deacetalization-Knoevenagel condensation tandem reaction. Compared with ZIF-8 and amine-functionalized ZIF-8 catalysts, ZIF8-A61-SO3H catalyst showed good catalytic performance with 100% conversion of the reactant and 98% selectivity of the final Knoevenagel product. An enhanced catalytic activity can be attributed to the co-existence of site-isolated acid-base groups on the ZIF8-A61-SO3H catalyst in close proximity. The heterogeneous nature of the catalytic system was confirmed by a hot-filtering test and the catalyst also exhibited reusable in the five repeated cycles. A plausible catalytic mechanism of deacetalization-Knoevenagel condensation reaction over ZIF8-A61-SO3H was also proposed.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Lee, YR; Do, XH; Hwang, SS; Baek, KY or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM in [Pisa, Rudolf; Cupido, Tommaso; Steinman, Jonathan B.; Jones, Natalie H.; Kapoor, Tarun M.] Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA; [Pisa, Rudolf; Jones, Natalie H.] Rockefeller Univ, Triinst PhD Program Chem Biol, New York, NY 10065 USA; [Steinman, Jonathan B.] Weill Cornell Rockefeller Sloan Kettering Triinst, New York, NY 10065 USA published Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins in 2019.0, Cited 45.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article New protocols for the synthesis of 5-amino-7-(4-phenyl)-4,7-dihydro-[1,2,4] triazolo [1,5-a] pyrimidine-6-carboxylate esters using an efficient additive WOS:000560919000017 published article about IONIC LIQUIDS; CATALYST; GREEN; ACID in [Ghaffari Khaligh, Nader; Shahnavaz, Zohreh; Rafie Johan, Mohd] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Inst Postgrad Studies, Kuala Lumpur, Malaysia; [Mihankhah, Taraneh] Iran Univ Sci & Technol, Dept Water & Environm Engn, Tehran, Iran; [Titinchi, Salam] Univ Western Cape, Dept Chem, Cape Town, South Africa in 2020.0, Cited 22.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

This work introduces a new additive named 4,4′-trimethylenedipiperidine for the practical and ecofriendly preparation of ethyl 5-amino-7-(4-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate derivatives. This chemical is commercially available and easy to handle. It also possesses a low melting point and a broad liquid range temperature, high thermal stability, and good solubility in water. Based on green chemistry principles, the reaction was performed in a) a mixture of green solvents i.e. water and ethanol (1:1 v/v) at reflux temperature, and b) the additive was liquefied at 65 degrees C and the reaction was conducted in the liquid state of the additive. High yields of the desired triazolo-pyrimidines were obtained under both aforementioned conditions. Our results demonstrated that this additive, containing 2 Lewis base sites and able to act as an acceptor-donor hydrogen bonding group, is a novel and efficient alternative to piperidine, owing to its unique properties such as its reduced toxicity, nonflammable nature, nonvolatile state, broad liquid range temperature, high thermal stability, and ability to be safely handled. Furthermore, this additive could be completely recovered and exhibited high recyclability without any change in its chemical structure and no significant reduction in its activity. The current methodology has several advantages: (a) it avoids the use of hazardous materials, as well as toxic, volatile, and flammable solvents, (b) it does not entail tedious processes, harsh conditions, and the multistep preparation of catalysts, (c) it uses a metal-free and noncorrosive catalyst, and (d) reduces the generation of hazardous waste and simple work-up processes. The most important result of this study is that 4,4′-trimethylenedipiperidine can be a promising alternative for toxic, volatile, and flammable base reagents in organic synthesis owing to its unique properties.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Ghaffari Khaligh, N; Mihankhah, T; Titinchi, S; Shahnavaz, Z; Rafie Johan, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Zhou, SH; Xu, HB; Liu, JY; Wei, YJ; Ma, XH; Han, ZM; Chen, HL in ELSEVIER published article about GOLD NANOPARTICLES; NANOPOROUS CARBON; POROUS CARBON; SULFUR; SENSOR in [Zhou, Shenghai; Xu, Hongbo; Liu, Jinyu; Wei, Yajun; Ma, Xinhuan; Han, Zhimin; Chen, Hongli] Hebei Normal Univ Nationalities, Coll Chem & Chem Engn, Chengde 067000, Peoples R China in 2021.0, Cited 45.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

N-doped carbon nanopipe-arrayed mesoporous carbon (N-CMK-5) with double-pore system, large surface area (992 m(2)/g), and high nitrogen amount (5.2 at.%) was synthesized by a simplified template route. In this route, mesoporous silica was directly used instead of using time-consuming aluminosilicate as a template and the carbonization process occurred in a nitrogen atmosphere instead of a vacuum. Furthermore, CMK-3, N-doped CMK-3, and CMK-5 ordered mesopomus carbons (OMCs) were compared with the as-prepared N-doped CMK-5 (N-CMK-5) to investigate the effect of microstructure on the electrochemical activity of OMCs. N-CMK-5 exhibited higher electrochemical activity than the other OMCs because it has more exposed defective sites and nitrogen active species. The developed N-CMK-5-based electrochemical sensor showed good practical application for the electrochemical detection of pesticide amitrole in real water sample. This work contributes a simplified route to synthesize tubular N-CMK-5 carbon and provides valuable information on the design of high-performance carbon electrode materials.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Liu, JY; Wei, YJ; Ma, XH; Han, ZM; Chen, HL or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of 1H-1,2,4-Triazol-5-amine. Authors Abdel-Kader, NS; Moustafa, H; El-Ansary, AL; Sherif, OE; Farghaly, AM in ROYAL SOC CHEMISTRY published article about in [Abdel-Kader, Nora S.; Moustafa, Hussein; El-Ansary, Aida L.; Sherif, Omaima E.] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt; [Farghaly, Aya M.] Cairo Univ, Ctr Environm Hazard Mitigat, Giza, Egypt in 2021.0, Cited 71.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

8-Acetyl-7-hydroxy-4-methyl coumarin and 3-amion-1,2,4-triazole were used to prepare a Schiff base (Sbat). The [Ag(Sbat)(NO3)]center dot H2O and [Cu(Sbat)(OH)(H2O)(2)]center dot 3H(2)O complexes were separated by the reaction of the Schiff base with Ag(i) and Cu(ii) metal ions. All the prepared compounds were subjected to elemental and spectral analyses (IR, UV-vis, H-1 NMR, and mass spectroscopy). Moreover, the complexes were also subjected to TG analysis, molar conductance measurements, magnetic moment analysis, and XRD measurements. The value of the molar conductance designates their non-electrolytic character. The local minimum structure, global properties and nonlinear optical parameters of the Schiff base were calculated at the B3LYP/6-31++(d,p) level of theory and those of its complexes were calculated at the B3LYP/GENECP level. The electronic spectra in the UV-visible region of the Schiff base (Sbat) and [Ag(Sbat)(NO3)]center dot H2O and [Cu(Sbat)(OH)(H2O)(2)]center dot 3H(2)O complexes in DMSO as a solvent were investigated experimentally and theoretically using the time dependent density functional theory (TD-DFT) method at the CAM-B3LYP/6-311++G(d,p) level of theory. The studied compounds were screened for their in vitro antibacterial activity against three Gram-positive (B. subtilis, S. aureus and S. faecalis) and three Gram-negative bacteria (E. coli, N. gonorrhoeae and P. auregenosa). An antifungal assay was performed against two fungal (C. albicans and A. flavus) species. The Ag-Sbat complex showed the highest antimicrobial activity. The cytotoxic activity of the Schiff base and its silver complex was tested in vitro against the MCF-7 (breast cancer) and HCT-116 (colon cancer) cell lines.

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Abdel-Kader, NS; Moustafa, H; El-Ansary, AL; Sherif, OE; Farghaly, AM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. In 2020.0 ENVIRON SCI TECHNOL published article about THROUGHPUT SCREENING ASSAYS; DRUG DISCOVERY; BINDING AFFINITIES; TOXCAST CHEMICALS; QSAR; IDENTIFICATION; CLASSIFICATION; AGREEMENT; SET in [Zorn, Kimberley M.; Foil, Daniel H.; Lane, Thomas R.; Ekins, Sean] Collaborat Pharmaceut Inc, Raleigh, NC 27606 USA; [Russo, Daniel P.] Rutgers State Univ, Ctr Computat & Integrat Biol, Camden, NJ 08102 USA; [Hillwalker, Wendy; Feifarek, David J.; Jones, Frank; Klaren, William D.; Brinkman, Ashley M.] SC Johnson & Son Inc, Global Prod Safety, Racine, WI 53404 USA in 2020.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The U.S. Environmental Protection Agency (EPA) periodically releases in vitro data across a variety of targets, including the estrogen receptor (ER). In 2015, the EPA used these data to construct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrine disruption testing. However, mathematical models require in vitro data prior to predicting estrogenic activity, but machine learning methods are capable of prospective prediction from the molecular structure alone. The current study describes the generation and evaluation of Bayesian machine learning models grouped by the EPA’s ER agonist pathway model using multiple data types with proprietary software, Assay Central. External predictions with three test sets of in vitro and in vivo reference chemicals with agonist activity classifications were compared to previous mathematical model publications. Training data sets were subjected to additional machine learning algorithms and compared with rank normalized scores of internal five-fold cross-validation statistics. External predictions were found to be comparable or superior to previous studies published by the EPA. When assessing six additional algorithms for the training data sets, Assay Central performed similarly at a reduced computational cost. This study demonstrates that machine learning can prioritize chemicals for future in vitro and in vivo testing of ER agonism.

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 HYPERTENS RES published article about RENIN-ANGIOTENSIN SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANTEROVENTRAL 3RD-VENTRICLE AV3V; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; RENAL-HYPERTENSION; PRESSOR-RESPONSES; BLOOD-PRESSURE; RENOVASCULAR HYPERTENSION; CARDIOVASCULAR-RESPONSES in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ, Dent Sch, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil; [Blanch, Graziela T.] Pontifical Catholic Univ Goias, Sch Med Pharm & Biomed, Goiania, Go, Brazil in 2020.0, Cited 69.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 mu mol/1 mu l) or ATZ (5 nmol/1 mu l) icv reduced the pressor responses to ANG II (50 ng/1 mu l) icv in SHRs (11 +/- 3 and 17 +/- 4 mmHg, respectively, vs. 35 +/- 6 mmHg) and 2K1C hypertensive rats (3 +/- 1 and 16 +/- 3 mmHg, respectively, vs. 26 +/- 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Lauar, MR; Blanch, GT; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kolodziej, B; Morawiak, M; Schilf, W; Kamienski, B in [Kolodziej, Beata] West Pomeranian Univ Technol, Fac Chem Technol & Engn, Dept Inorgan & Analyt Chem, Al Piastow 42, PL-71065 Szczecin, Poland; [Morawiak, Maja; Schilf, Wojciech; Kamienski, Bohdan] Polish Acad Sci, Inst Organ Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Kamienski, Bohdan] Polish Acad Sci, Inst Phys Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland published Structure investigations of Schiff bases derived from 3-amino-1H-1,2,4-triazole in 2019.0, Cited 62.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In the present paper, twelve Schiff bases derived from 3-amino-1H-1,2,4-triazole (ATz) and various benzaldehydes, and salicylaldehydes were synthesized. The H-1, C-13, and N-15 NMR data are discussed in relation to the structure of ATz and its imine products. In addition, X-ray, ATR-FTIR, and UV-Vis analytical techniques are used for structure elucidation of ATz-based Schiff bases. It was found that the starting material, 3-amino-1H-1,2,4-triazole, exists as tautomeric mixture of three forms (Graphical Abstract) in solution, whereas in the solid state (C-13 and N-15 CPMAS data) potentially tautomeric proton is located on nitrogen atom traditionally marked as N-2 (Graphical Abstract, 2N-H structure). All investigated Schiff bases derived from salicylaldehydes exist in both phases as tautomeric equilibrium mixtures, where enol-imine forms are dominated structures. The positions of those equilibria only very slightly depend on substituents in phenol ring. Generally, the contributions of keto-amine forms in the solid state are higher comparing with DMSO solutions. (C) 2019 Published by Elsevier B.V.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Kolodziej, B; Morawiak, M; Schilf, W; Kamienski, B or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics