Triazoles

Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane was written by Zhang, Xiao;Morikawa, Kota;Mori, Yurie;Zong, Cai;Zhang, Lingyi;Garner, Edwin;Huang, Chinyen;Wu, Wenting;Chang, Jie;Nagashima, Daichi;Sakurai, Toshihiro;Ichihara, Sahoko;Oikawa, Shinji;Ichihara, Gaku. And the article was included in Archives of Toxicology in 2020.Product Details of 1614-12-6 This article mentions the following:

The aim of the present study was to characterize the mol. mechanisms of 1,2-DCP-induced hepatotoxic effects by proteomic anal. We analyzed quant. the differential expression of proteins in the mouse liver and investigated the role of P 450 in mediating the effects of 1,2-DCP. Male C57BL/6JJcl mice were exposed to 0, 50, 250, or 1250 ppm 1,2-DCP and treated with either 1-aminobenzotriazole (1-ABT), a nonselective P 450 inhibitor, or saline, for 8 h/day for 4 wk. Two-dimensional difference in gel electrophoresis (2D-DIGE) combined with matrix-assisted laser-desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF/MS) was used to detect and identify proteins affected by the treatment. PANTHER overrepresentation test on the identified proteins was conducted. 2D-DIGE detected 61 spots with significantly different intensity between 0 and 250 ppm 1,2-DCP groups. Linear regression anal. showed significant trend with 1,2-DCP level in 17 proteins in mice co-treated with 1-ABT. 1-ABT mitigated the differential expression of these proteins. The gene ontol. enrichment anal. showed overrepresentation of proteins functionally related to nickel cation binding, carboxylic ester hydrolase activity, and catalytic activity. The results demonstrated that exposure to 1,2-DCP altered the expression of proteins related with catalytic and carboxylic ester hydrolase activities, and that such effect was mediated by P 450 enzymic activity. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A new family of 3d-4f heterometallic coordination polymers assembled with 1H-1,2,3-triazole-4,5-dicarboxylic acid: syntheses, structures and magnetic properties was written by Zou, Ji-Yong;Xu, Na;Shi, Wei;Gao, Hong-Ling;Cui, Jian-Zhong;Cheng, Peng. And the article was included in RSC Advances in 2013.Synthetic Route of C4H3N3O4 This article mentions the following:

Five isostructural copper(II)-lanthanide(iii) heterometallic coordination polymers (CPs), {[Cu₂Ln(TDA)₂Cl(H₂O)₄]·2H₂O}_n [Ln = Gd (Cu-Gd), Tb (Cu-Tb), Dy (Cu-Dy), Ho (Cu-Ho) and Er (Cu-Er)] (H₃TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid), were synthesized under solvothermal conditions and structurally characterized. In these CPs, two neighboring Cu(II) ions are connected via one μ₂-Cl to form [Cu₂Cl]³⁺ units, which are further linked into a copper chain through bridging TDA^3-. The neighboring copper chains are further connected by lanthanide to form a two-dimensional structure with sql topol. The magnetic properties of the five isostructural heterometallic CPs were studied as well. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lanthanide-based coordination compounds based on 4-(4-carboxyphenyl)-1,2,4-triazole: synthesis, structures, Hirshfeld surface and luminescence properties was written by Liu, Qing-Ling;Yang, Li-Jing;Luo, Yang-Hui;Sun, Bai-Wang. And the article was included in New Journal of Chemistry in 2016.Synthetic Route of C9H7N3O2 This article mentions the following:

Four novel lanthanide compounds based on the 4-(4-carboxyphenyl)-1,2,4-triazole ligand (Hcpt), {[Pr₂(cpt)₄(H₂O)₁₀]·10H₂O·2ClO₄} (1), {[Ln(cpt)₂(H₂O)₂(OH)]·4H₂O}_n (Ln = Er (2), Lu (3)), and {[Sm(cpt)₂(CH₃CH₂OH)(H₂O)₃]·ClO₄}_n (4), were obtained under hydrothermal conditions and further characterized by elemental anal., single-crystal x-ray diffraction and TGA. Compound 1 exhibits a discrete dinuclear structure constructed by one cpt^– ligand coordinated to two Pr³⁺ ions and another cpt^– ligand coordinated to more than one Pr³⁺ ion. Compounds 2 and 3 are isomorphous and every cpt^– ligand coordinates to two Ln³⁺ ions, resulting in a polymeric 1-dimensional chain structure. Different from the above compounds, the nitrogen atoms of triazole are also involved in the coordination of compound 4. One cpt^– ligand coordinates to two Sm³⁺ ions and another cpt^– ligand coordinates to more than one Sm³⁺ ion, meanwhile, the nitrogen atoms of triazole coordinate to the 3rd Sm³⁺ ion, resulting in a 2-dimensional polymeric network structure. The luminescence properties of compound 4 were characterized, and it exhibited characteristic Sm³⁺ emission in the yellow region. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Synthetic Route of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Catalyst-free one-pot, four-component approach for the synthesis of di- and tri-substituted N-sulfonyl formamidines was written by Liu, Ai-Ran;Zhang, Lei;Li, Jiao;Wusiman, Abudureheman. And the article was included in RSC Advances in 2021.Electric Literature of C5H7N3O2 This article mentions the following:

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN₃, Et propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural anal. of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogs only formed E-isomers. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Electric Literature of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Electric Literature of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Multi-step Phase Transformation from Metal-Organic Frameworks to Inorganic Compounds for High-Purity Th(IV) Generation was written by Huang, Yi-wei;Feng, Han;Xiong, Xiao-hong;Luo, Feng. And the article was included in Inorganic Chemistry in 2022.Synthetic Route of C9H7N3O2 This article mentions the following:

The generation of high-purity thorium is the precondition for next-generation nuclear energy; however, this remains a challenging task. To this end, the authors present herein an ultrasimple technique with the combination of crystallization plus phase transformation. Crystallization into ECUT-68 is found to show almost 100% selective uptake of Th(IV) over rare earth and UO₂²⁺ ions, while multistep phase transformation from metal-organic frameworks (MOFs) to inorganic compounds is found to directly generate inorganic Th(IV) compound and then Th(IV) solution, suggesting its superior application in the generation of high-purity thorium. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Synthetic Route of C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Synthetic Route of C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Additive-Induced Supramolecular Isomerism and Enhancement of Robustness in Co(II)-Based MOFs for Efficiently Trapping Acetylene from Acetylene-Containing Mixtures was written by Ye, Yingxiang;Chen, Shimin;Chen, Liangji;Huang, Jitao;Ma, Zhenlin;Li, Ziyin;Yao, Zizhu;Zhang, Jindan;Zhang, Zhangjing;Xiang, Shengchang. And the article was included in ACS Applied Materials & Interfaces in 2018.Product Details of 157069-48-2 This article mentions the following:

Although supramol. isomerism in metal-organic frameworks (MOFs) would offer a favorable platform for in-depth exploring their structure-property relationship, the design and synthesis of the isomers are still rather a challenging aspect of crystal engineering. Here, a pair of supramol. isomers of Co(II)-based MOFs (FJU-88 and FJU-89) can be directionally fabricated by rational tuning the additives. In spite of the fact that the isomers have the similar Co₃ secondary building units and organic linkers, they adopt distinct networks with acs and snw topologies, resp., which derive from the conformational flexibility of the organic ligands. It is noteworthy that the porous structure of FJU-88 would be collapsed after removal of the solvent from the pores. But FJU-89a shows permanent porosity accompanied with unusual hierarchical micro- and mesopores and superior gas selective adsorption performance. In addition, FJU-89a can efficiently trap C₂H₂ from C₂H₂/CO₂ and C₂H₂/CH₄ mixture gases through fixed-bed dynamic breakthrough experiments In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Product Details of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Product Details of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Biodegradation and detoxification of neonicotinoid insecticide thiamethoxam by white-rot fungus Phanerochaete chrysosporium was written by Chen, Anwei;Li, Wenjie;Zhang, Xiaoxiao;Shang, Cui;Luo, Si;Cao, Ruoyu;Jin, Doudou. And the article was included in Journal of Hazardous Materials in 2021.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

The extensive use of neonicotinoid pesticides in the past two decades caused serious impacts on many kinds of living beings. Therefore, it has been strongly suggested to detoxify and eliminate neonicotinoids′ residual levels in environment. Here, the degradation and detoxification of thiamethoxam (THX) by white-rot fungus Phanerochaete chrysosporium was conducted. Results shown that P. chrysosporium can tolerate THX and degraded 49% of THX after incubation for 15 days, and then 98% for 25 days at the initial concentration of 10 mg/L, which indicates the excellent degradation ability of this fungus to THX. Based on the byproducts identified, THX underwent dechlorination, nitrate reduction, and C-N cleavage between the 2-chlorothiazole ring and oxadiazine. (Z)-N-(3-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide and 3-methyl-1,3,5-oxadiazinan-4-imine were identified as the main metabolites. The impacts of THX and its corresponding degradation intermediates on the growth of E. coil and Microcystis aeruginosa as well as the germination of rape and cabbage demonstrated that P. chrysosporium effectively degrades THX into metabolites and reduces its biotoxicity. The present work demonstrates that P. chrysosporium can be effectively used for degradation and detoxification of THX. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis, structure, and fungicidal activity of triorganotin (4H-1,2,4-triazol-4-yl)benzoates was written by Li, Fang-Lin;Dai, Bin;Song, Hai-Bin;Mi, Na;Tang, Liang-Fu. And the article was included in Heteroatom Chemistry in 2010.Application of 157069-48-2 This article mentions the following:

A series of triorganotin (4H-1,2,4-triazol-4-yl)benzoates have been synthesized by the reaction of 4-(4H-1,2,4-triazol-4-yl)benzoic acid and 3-(4H-1,2,4-triazol-4-yl)benzoic acid with (R₃Sn)₂O (R = Et, n-Bu and Ph) or R’₃SnOH (R’ = p-tolyl and cyclohexyl). The mol. structure of tri(p-tolyl)tin 3-(4H-1,2,4-triazol-4-yl)benzoate determined by x-ray crystallog. displays that the tin atom adopts a five-coordinate distorted trigonal bipyramidal geometry with the carboxyl oxygen atom and the nitrogen atom on 1-position of triazole ring occupying the apical position. Moreover, this complex forms a polymeric chain by the intermol. Sn-N interactions. All these complexes show good antifungal activities in vitro against Alternaria solani, Cercospora arachidicola, Gibberella zeae, Physalospora piricola, and Botrytis cinerea. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 20:411-417, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20566. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Application of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Application of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A hexanuclear Co^II complex assembled with 1H-1,2,3-triazole-4,5-dicarboxylic acid: synthesis, crystal structure and magnetic property was written by Zou, Ji-yong;Shi, Wei;Gao, Hong-ling;Cui, Jian-zhong;Cheng, Peng. And the article was included in Wuji Huaxue Xuebao in 2014.SDS of cas: 4546-95-6 This article mentions the following:

A new hexanuclear Co^II complex, namely [Co₆(TDA)₄(H₂O)₁₄]·5H₂O (1) (H₃TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid), has been successfully synthesized and characterized by IR spectra, elemental anal., thermogravimetric anal., powder and single-crystal X-ray diffraction. Complex 1 crystallizes in orthorhombic space group P2₁2₁2, with cell parameters: a = 1.64730(2) nm, 6 = 1.65330(2) nm, c = 0.7326 90(10) nm and Flack parameter of 0.00(13). In title complex, six Co^II ions are connected by four TDA^3- ligands to form a hexanuclear Co^II unit, which can be extended to a 3D supramol. architecture through the hydrogen-bonding interactions. Magnetic study reveals the dominant antiferromagnetic interaction exist between Co^II ions in 1. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6SDS of cas: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.SDS of cas: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hydrogen cyanide. X. The tetrapolymer was written by Hinkel, L. E.;Richards, G. O.;Thomas, O.. And the article was included in Journal of the Chemical Society in 1937.Product Details of 4546-95-6 This article mentions the following:

The previous evidence for the structure of the polymerized form of HCN is reviewed and further evidence is adduced for its quadrimol. nature. The view that the polymer is diaminomaleic dinitrile is shown to be incorrect and experiments indicate it to be aminoiminosucconitrile (I). The polymerization product of HCN, m. 181° (decomposition), condenses with glyoxal in hot H₂O to give 6-hydroxy-2,3-dicyanodihydropyrazine, red, amorphous, decomposes 240° without melting; it is very slowly decomposed by boiling H₂O, but H₂O containing a little (CO₂H)₂ gives dicyanopyrazine (II), m. 132°. Hydrolysis of II by Na₂O₂ in H₂O and purification through the Ag salt give pyrazinedicarboxylic acid, m. 193°. The polymer of HCN in Et₂O, saturated with dry HCl, gives the HCl salt of I, decomposes 135°. Refluxing the polymer with aldehydes in EtOH for 30 min. gives the following derivatives of I: benzylidene (III), yellow, m. 191° (decomposition); salicylidene, yellow with green tinge, m. 234° (decomposition); m-bromosalicylidene, yellow, m. above 250°; anisylidene, yellow, m. 227° (decomposition); isobutylidene, m. 91° (decomposition); in no case could a 2nd mol. of aldehyde be condensed. The Ac derivative of I m. 164° (decomposition); the di-Ac derivative m. 224° (decomposition); the Ac derivative of III m. 227° (decomposition). Ac₂ and I give 2,3-dicyano-5,6-dimethylpyrazine (IV), m. 171°; benzil forms 2,3-dicyano-5,6-diphenylpyrazine, m. 246°. Hydrolysis of IV gives 2,3-dimethylpyrazine-5,6-dicarboxylic acid, m. 200°. The action of HNO₂ on I yields 4,5-dicyano-1,2,3-triazole (V), hydrolysis of which gives 1,2,3-triazole-4,5-dicarboxylic acid. The action of HNO₂ on the Ac derivative of I forms 4 (or 5)-cyano-1,2,3-triazole-5 (or 4)-carboxamide, m. 219° (decomposition), and V. Oxidation of III gives 4,5-dicyano-2-phenyliminazole, cream, m. 261° (decomposition); hydrolysis gives 2-phenyliminazole-4,5-dicarboxylic acid, m. 243-4°. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Product Details of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Product Details of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics